Costs and benefits of multifactorial falls prevention in nursing homes in the Netherlands.

Abstract:

OBJECTIVES:To investigate whether the implementation of a multifactorial falls intervention in nursing homes is cost-beneficial and alleviates the professional workload. DESIGN:A comprehensive quantitative model was developed to calculate the impact of investments in multifactorial falls prevention in nursing homes in the Netherlands, comparing the fall incidence using intervention strategies in 1000 nursing home residents with the conditions of usual care over a five-year timeline. SETTING AND PARTICIPANTS:We built a model combining several data sources regarding falls and injury prevalence in nursing home residents, health care costs, intervention costs and effectiveness, and demographic statistics. MEASURES:The primary outcomes were number of falls and injuries, treatment hours and cost. RESULTS:In the nursing home setting, a baseline scenario was calculated with 1471 falls incidents resulting in 345 injuries per year. The mean cost of injury related treatment and care was calculated 860 thousand euro per year and €4.63 million in five years. Implementing multifactorial intervention over five years, costing 702 thousand euro, resulted in savings in health care costs of €2.0 million, of which €1.6 million was saved in nursing home injury care. The benefits outweighed the costs: each euro invested was compensated by 2.86 euro benefit in total care, 2.31 benefit in nursing home care. Yearly 3050 nursing hours, 3100 paramedical care hours and 760 h of physician care were saved. CONCLUSION AND IMPLICATIONS:Implementation of customized multifactorial interventions provided by multidisciplinary teams is cost-beneficial in reduction of falls in nursing homes. The CBA model gives valuable information about the advantageous consequences (i.e. health benefits, financial benefits and reduced workload of staff) of falls prevention in nursing homes and can provide guidance to the management in structural implementation of multifactorial falls prevention.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Panneman MJM,Sterke CS,Eilering MJ,Blatter BM,Polinder S,Van Beeck EF

doi

10.1016/j.exger.2020.111173

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

111173

eissn

0531-5565

issn

1873-6815

pii

S0531-5565(20)30521-0

journal_volume

143

pub_type

杂志文章
  • Mechanical and non-mechanical functions of Dystrophin can prevent cardiac abnormalities in Drosophila.

    abstract::Dystrophin-deficiency causes cardiomyopathies and shortens the life expectancy of Duchenne and Becker muscular dystrophy patients. Restoring Dystrophin expression in the heart by gene transfer is a promising avenue to explore as a therapy. Truncated Dystrophin gene constructs have been engineered and shown to alleviat...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2013.10.015

    authors: Taghli-Lamallem O,Jagla K,Chamberlain JS,Bodmer R

    更新日期:2014-01-01 00:00:00

  • Different rates of telomere shortening and telomerase activity reduction in CD8 T and CD16 NK lymphocytes with ageing.

    abstract::Telomeres are specialised structures located at the end of eukaryotic chromosomes, that get short during progressive cell divisions. Therefore, telomere may be an indicator of the mitotic history of a cell and it is also a determining factor for the residual cell life span. One mechanism, compensating for the telomere...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(03)00058-5

    authors: Mariani E,Meneghetti A,Formentini I,Neri S,Cattini L,Ravaglia G,Forti P,Facchini A

    更新日期:2003-06-01 00:00:00

  • The importance of inflammatory mechanisms for the development of Alzheimer's disease.

    abstract::A variety of inflammatory proteins has been identified in brains of patients with Alzheimer's disease. The current data suggest that the inflammatory processes are intimately involved in several crucial events in the pathological cascade. Immunohistochemical studies reveal that those parts of the brain wherein the amy...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审

    doi:10.1016/s0531-5565(99)00022-4

    authors: Eikelenboom P,Veerhuis R

    更新日期:1999-06-01 00:00:00

  • Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice.

    abstract::Rapamycin consistently increases longevity in mice although the mechanism of action of this drug is unknown. In the present investigation we studied the effect of rapamycin on mitochondrial oxidative stress at the same dose that is known to increase longevity in mice (14mgofrapamycin/kg of diet). Middle aged mice (16m...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2016.08.002

    authors: Martínez-Cisuelo V,Gómez J,García-Junceda I,Naudí A,Cabré R,Mota-Martorell N,López-Torres M,González-Sánchez M,Pamplona R,Barja G

    更新日期:2016-10-01 00:00:00

  • Proteomic analysis of post-mitochondrial fractions of young and old rat kidney.

    abstract::Proteomic analysis is defined as the characterization of the entire set of proteins encoded by a genome. Two-dimensional (2D) electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) are key technologies used in proteomic analysis to gain information about protein...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2004.04.003

    authors: Kim CH,Park DU,Chung AS,Zou Y,Jung KJ,Sung BK,Yu BP,Chung HY

    更新日期:2004-08-01 00:00:00

  • Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study.

    abstract:BACKGROUNDS:Elucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and intervention procedures. METHODS:We conducted two-stage time-to-event Mendelian randomization meta-analyses combining five large-scale longitudinal cohorts ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2017.09.019

    authors: He L,Culminskaya I,Loika Y,Arbeev KG,Bagley O,Duan M,Yashin AI,Kulminski AM

    更新日期:2018-07-01 00:00:00

  • Physiological oxygen tension is relevant to MHC-1 expression, spontaneous transformation, and interferon response of in vitro aging murine fibroblasts.

    abstract::Working from the hypothesis that modest deviations from physiological oxygen tension will influence cell characteristics important for infections/immunity and tumor development, cells were studied at three oxygen tensions during in vitro aging. Primary mouse embryo fibroblasts were established and subsequently passage...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(93)90046-g

    authors: Ebbesen P,Hager H,Aboagye-Mathiesen G,Petersen PM,Lützhøft J,Villadsen JA,Zdravkovic M,Dalsgaard AM,Zachar V

    更新日期:1993-11-01 00:00:00

  • Age-related differences in the adaptive potential of type I skeletal muscle fibers.

    abstract::This study was designed to investigate whether the relationship of fiber size and force is maintained with aging and inactivity. We hypothesized that fiber size and fiber force-generating capacity would decrease in parallel, thus resulting in no change in specific force with either age or inactivity. Thirty male Fisch...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2004.12.002

    authors: Husom AD,Ferrington DA,Thompson LV

    更新日期:2005-03-01 00:00:00

  • Renal function in familial longevity: the Leiden Longevity Study.

    abstract::Studying renal function in subjects with a familial propensity for longevity may provide insight in (un)known mechanisms that determine the age-related decline in renal function of normal subjects. In the Leiden Longevity Study, middle-aged offspring of non-agenarian siblings and their partners as environmentally matc...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2013.12.012

    authors: de Goeij MC,Halbesma N,Dekker FW,Wijsman CA,van Heemst D,Maier AB,Mooijaart SP,Slagboom PE,Westendorp RG,de Craen AJ

    更新日期:2014-03-01 00:00:00

  • Collagens and elastin genetic variations and their potential role in aging-related diseases and longevity in humans.

    abstract::Collagens and elastin are 'building blocks' of tissues and extracellular matrix. Mutations in these proteins cause severe congenital syndromes. Adverse genetic variations may accelerate the aging process in adults contributing to premature morbidity, disability and/or mortality. Favorable variants may contribute to lo...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2019.110781

    authors: Romero-Ortuno R,Kenny RA,McManus R

    更新日期:2020-01-01 00:00:00

  • Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF.

    abstract::We previously demonstrated that in vitro stimulated splenic B cells from senescent mice are deficient in production of multiple class switch isotypes, class switch recombination (CSR), induction of the E2A-encoded transcription factor E47, and activation-induced cytidine deaminase (AID) which is necessary for CSR and ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2006.09.003

    authors: Frasca D,Riley RL,Blomberg BB

    更新日期:2007-03-01 00:00:00

  • Age-related changes in rat liver plasma membrane phospholipase A2 activity.

    abstract::The alterations of the lipid composition and fluidity of liver plasma membranes as well as the activity of membrane-bound phospholipase A2 (EC 3.1.1.4) in male and female rats of different ages are investigated. An age-induced increase of the protein/phospholipid and cholesterol/phospholipid ratios is observed, as wel...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(86)90072-0

    authors: Petkova DH,Momchilova AB,Koumanov KS

    更新日期:1986-01-01 00:00:00

  • Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment.

    abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disorder with characteristic neuropathological features that are accompanied by inflammatory processes and release of pro-inflammatory cytokines. There is evidence that microglial cells are a key mediator of damage in AD. The microglial compartment may arise ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2009.10.005

    authors: Hochstrasser T,Weiss E,Marksteiner J,Humpel C

    更新日期:2010-01-01 00:00:00

  • Adherence to the Mediterranean diet, dietary factors, and S-Klotho plasma levels in sedentary middle-aged adults.

    abstract:INTRODUCTION:The ageing process can be influenced by different dietary patterns and dietary factors. AIM:To analyse the association of dietary factors, which include the Mediterranean diet adherence, the compliance with the "Sociedad Española de Nutrición Comunitaria" food portion recommendations, and the intake of di...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2019.01.019

    authors: Jurado-Fasoli L,Amaro-Gahete FJ,De-la-O A,Martinez-Tellez B,Ruiz JR,Gutiérrez Á,Castillo MJ

    更新日期:2019-05-01 00:00:00

  • The role of cellular senescence on the cyclic stretching-mediated activation of MAPK and ALP expression and activity in human periodontal ligament fibroblasts.

    abstract::Mechanical loading is considered to be a major parameter of the periodontal ligament (PDL) remodeling and differentiation. However, the molecular mechanisms that translate these forces to cellular responses are not fully elucidated. Especially, although aging affects PDL homeostasis, the role of cellular senescence on...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2014.05.010

    authors: Konstantonis D,Papadopoulou A,Makou M,Eliades T,Basdra E,Kletsas D

    更新日期:2014-09-01 00:00:00

  • The influence of oxygen toxicity on yeast mother cell-specific aging.

    abstract::The effect of deleting both catalase genes and of increased oxygen as well as paraquat (a pro-oxidant) on the replicative life span of yeast mother cells has been investigated to test the so-called oxygen theory of aging. This is well established in higher organisms, but has not been extensively tested in the unicellu...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(99)00087-x

    authors: Nestelbacher R,Laun P,Vondráková D,Pichová A,Schüller C,Breitenbach M

    更新日期:2000-02-01 00:00:00

  • Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations--The LIFE Study.

    abstract:BACKGROUND:Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults. METHODS:Th...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.exger.2015.06.018

    authors: Mankowski RT,Aubertin-Leheudre M,Beavers DP,Botoseneanu A,Buford TW,Church T,Glynn NW,King AC,Liu C,Manini TM,Marsh AP,McDermott M,Nocera JR,Pahor M,Strotmeyer ES,Anton SD,LIFE Research Group.

    更新日期:2015-10-01 00:00:00

  • Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly.

    abstract::While influenza immunization significantly reduces the risk of pneumonia and associated deaths, vaccination of elderly only affords 30-50% protection against influenza disease. The purpose of this study was to: (1) evaluate the consistency of immune responses across multiple years in young and elderly; (2) determine t...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(01)00210-8

    authors: Murasko DM,Bernstein ED,Gardner EM,Gross P,Munk G,Dran S,Abrutyn E

    更新日期:2002-01-01 00:00:00

  • Pharmacological investigation of 'HIM-CHX': A herbal combination in the experimental muscle wasting condition.

    abstract::Muscle wasting diseases are gradually increasing with the increase in global life expectancy. This study was designed to evaluate the efficacy of HIM-CHX, a herbal combination of Boswellia serrata, Cissus quadrangularis, and Withania somnifera, on Sarcopenia. The effects of HIM-CHX on parameters such as muscle mass, g...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2019.110663

    authors: Azeemuddin MM,Rao CM,Rafiq M,Babu UV,Rangesh P

    更新日期:2019-10-01 00:00:00

  • Age related differences in diaphragm muscle fiber response to mid/long term controlled mechanical ventilation.

    abstract:BACKGROUND:Critically ill intensive care patients are subjected to controlled mechanical ventilation (CMV) which has an important association in triggering the impaired muscle function and the consequent delayed weaning from the respirator. AIM:The main aim of this study was to measure the effects of age and CMV over ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2014.06.017

    authors: Cacciani N,Ogilvie H,Larsson L

    更新日期:2014-11-01 00:00:00

  • Proteomic analysis of age dependent nitration of rat cardiac proteins by solution isoelectric focusing coupled to nanoHPLC tandem mass spectrometry.

    abstract::Protein nitration occurs as a result of oxidative stress induced by reactive oxygen (ROS) and reactive nitrogen species (RNS). Therefore, protein nitration serves as a hallmark for protein oxidation in vivo. We have previously reported on age dependent protein nitration in cardiac tissue of Fisher 344 BN-F1 rats analy...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2007.03.005

    authors: Hong SJ,Gokulrangan G,Schöneich C

    更新日期:2007-07-01 00:00:00

  • Chronic wound healing by fetal cell therapy may be explained by differential gene profiling observed in fetal versus old skin cells.

    abstract::Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can fabricate over 900 million biological bandages (9 x 12cm). In a...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2008.11.004

    authors: Ramelet AA,Hirt-Burri N,Raffoul W,Scaletta C,Pioletti DP,Offord E,Mansourian R,Applegate LA

    更新日期:2009-03-01 00:00:00

  • Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection.

    abstract::Post-viral pneumococcal pneumonia is a leading morbidity and mortality in older patients (≥65years of age). The goal of our current study is to understand the impact of chronological aging on innate immune responses to a secondary, post viral infection with Streptococcus pneumoniae, a causative agent of bacterial pneu...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2017.11.010

    authors: Cho SJ,Plataki M,Mitzel D,Lowry G,Rooney K,Stout-Delgado H

    更新日期:2018-05-01 00:00:00

  • Central markers of body fat distribution are important predictors of plasma lipids in elderly men and women.

    abstract::We determined the contribution of body fat distribution, peak VO2, fat mass, and dietary intake to variation in plasma lipids in elderly individuals. Volunteers were a healthy cohort of older Caucasian women (n = 75, mean age +/- SD, 72 +/- 5 years) and older men (n = 101, 72 +/- 5 years). We determined fat mass from ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(97)00052-1

    authors: Obisesan TO,Toth MJ,Ades PA,Poehlman ET

    更新日期:1997-11-01 00:00:00

  • Effect of age on DNA binding of the ku protein in irradiated human peripheral blood mononuclear cells (PBMC).

    abstract::DNA binding of the ku protein was investigated in peripheral blood mononuclear cells (PBMC) from 24 subjects of different ages (20-89 years old) displaying age-related changes in DNA repair, mitotic responsiveness, and cytokine production. Ku is an heterodimeric protein composed of two subunits of 70 and 80 kDa, which...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/s0531-5565(99)00026-1

    authors: Frasca D,Barattini P,Tirindelli D,Guidi L,Bartoloni C,Errani A,Costanzo M,Tricerri A,Pierelli L,Doria G

    更新日期:1999-08-01 00:00:00

  • Twenty-four hour growth hormone secretion in a patient with Werner's syndrome.

    abstract:OBJECTIVE:To assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome. DESIGN:Blood sampling every 20 min for 24 h followed by three daily injections of growth hormon...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(96)00031-9

    authors: Rubin CD,Reed B

    更新日期:1996-09-01 00:00:00

  • Memory performance of young and old subjects related to their erythrocyte characteristics.

    abstract::Several papers reported in recent years on a change in the age population distribution of the circulating erythrocytes in old mice, rats, rabbits, and humans. The results indicate the presence of a chronologically younger cell population in old animals and humans. The cells are typically lower in density and larger. I...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/0531-5565(92)90055-5

    authors: Danon D,Bologna NB,Gavendo S

    更新日期:1992-01-01 00:00:00

  • The relation between D-galactose injection and mitochondrial DNA 4834 bp deletion mutation.

    abstract::Since,D-galactose (D-gal) overload model has been used as a premature aging model, we hypothesized that it may also lead to accelerated aging in the inner ear. Furthermore, though the mitochondrial DNA (mtDNA) 4834 bp deletion mutation has been considered as the marker of aging, there is no information available in th...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2006.04.008

    authors: Kong WJ,Wang Y,Wang Q,Hu YJ,Han YC,Liu J

    更新日期:2006-06-01 00:00:00

  • The mitochondrial O-linked N-acetylglucosamine transferase (mOGT) in the diabetic patient could be the initial trigger to develop Alzheimer disease.

    abstract::Diabetes mellitus (DM) is considered a risk factor for the development of Alzheimer disease (AD); however, how DM favors evolution of AD is still insufficiently understood. Hyperglycemia in DM is associated to an increase in mitochondrial reactive oxygen species (ROS) generation, as well as damage of hippocampal cells...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2014.08.008

    authors: Lozano L,Lara-Lemus R,Zenteno E,Alvarado-Vásquez N

    更新日期:2014-10-01 00:00:00

  • A prospective study on the association of sleep duration with grip strength among middle-aged and older Chinese.

    abstract:BACKGROUND:Longitudinal studies on sleep duration and grip strength decline are limited. This study aimed to evaluate the associations of baseline sleep duration with follow-up grip strength and grip strength changeover time among a large sample of middle-aged and older Chinese. METHODS:Data from China Health and Reti...

    journal_title:Experimental gerontology

    pub_type: 杂志文章

    doi:10.1016/j.exger.2018.01.009

    authors: Wang TY,Wu Y,Wang T,Li Y,Zhang D

    更新日期:2018-03-01 00:00:00