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Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls.

Abstract：

:The abundance of a selection of transcript species involved in inflammation, immunosenescence and stress response was compared between PBMC of 35 geriatric patients with hip fracture in acute phase (days 2-4 after hospitalization) or convalescence phase (days 7-10) and 28 healthy aged controls. Twenty-nine differentially abundant transcripts were identified in acute phase versus healthy ageing. Twelve of these transcripts remained differentially abundant in convalescence phase, and 22 were similarly differentially abundant in acute phase of geriatric infectious diseases. Seven of these 22 transcripts were previously identified as differentially abundant in PBMC of healthy aged versus healthy young controls, with further alteration for CD28, CD69, LCK, CTSD, HMOX1, and TNFRSF1A in acute phase after geriatric hip fracture and infectious diseases. The next question is whether these alterations are common to other geriatric diseases and/or preexist before the clinical onset of the diseases.

journal_name

Exp Gerontol

journal_title

Experimental gerontology

authors

Vo TK,Godard P,de Saint-Hubert M,Morrhaye G,Debacq-Chainiaux F,Swine C,Geenen V,Martens HJ,Toussaint O

doi

10.1016/j.exger.2010.10.012

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

257-64

issue

4

eissn

0531-5565

issn

1873-6815

pii

S0531-5565(10)00388-8

journal_volume

46

pub_type

杂志文章

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