Abstract:
:Spatial memory deficits occur earlier in female than male rodents as the animals age, and the cessation of estrous cycle has been suggested to play a role in this phenomenon. We examined the effects of long-term ovariectomy (OVX) and estrogen replacement therapy (ERT) with subcutaneous 17beta-estradiol minipellets on maze learning in aged (24-month-old) female C57BL/6J mice using a win-stay task (1/8 arms baited) in the radial arm maze (RAM) and a position discrimination task in the T-maze. ERT was started 40 days before the behavioral tests both in gonadally intact (sham-operated) and OVX mice. The effect of early OVX on RAM performance was investigated using three different age groups (7, 11 and 24 months) with different OVX durations (4, 8 and 19 months, respectively). ERT reduced the number of reference memory errors in RAM in aged sham-operated and OVX mice, but unlike in young mice (Heikkinen et al., 2002) it had no effect on working memory errors. Furthermore, OVX impaired the performance of aged mice in the T-maze. Comparison across the three age groups and three OVX durations indicated that the memory impairment induced by an early age OVX attenuates as the mice get close to their estropausal age.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Heikkinen T,Puoliväli J,Tanila Hdoi
10.1016/j.exger.2004.05.005keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
1277-83issue
9eissn
0531-5565issn
1873-6815pii
S0531556504001895journal_volume
39pub_type
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doi:10.1016/j.exger.2003.09.018
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