Hormonal modulation of antioxidant enzyme activities in young and old rats.


:The correlation between serum levels of pituitary and thyroid hormones and the activity of two antioxidant enzymes (AOE), catalase (CAT) and superoxide dismutase (SOD), in different immune and nonimmune organs of young and old rats was investigated. Serum levels of growth hormone (GH), prolactin (Prl), thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroxine (T4), and triiodothyronine (T3) as well as the activity of AOE in liver (CAT and SOD), spleen (CAT and SOD), thymus (SOD) and mammary tissue (SOD) were determined in 7- and 29-month-old Sprague-Dawley female rats. A marked hyperprolactinemia and lower levels of TSH, LH, FSH and GH were observed in the old rats when compared to the young ones (p < 0.05). Old animals showed a higher SOD activity in liver and thymus but a lower activity in spleen than their young counterparts (p < 0.05). In addition, CAT activity in spleen was lower in old than in young rats (p < 0.05). The Spearman's test revealed a positive correlation between: 1) serum levels of TSH and the activity of SOD in liver and 2) serum levels of Prl and GH and the activity of SOD in mammary tissue of young and old animals (p < 0.05). Likewise, CAT in liver showed a highly significant correlation with serum TSH (but not T4 and T3) levels in young (p < 0.01) but not in old rats. Our results confirm that aging is associated with alterations in the endocrine balance and the activity of AOE in lymphoid as well as in nonimmune organs. In addition, our findings suggest that Prl and GH may be physiological modulators of mammary SOD activity, and that TSH can possibly influence the activity of both CAT and SOD in liver via a thyroid-independent pathway. Furthermore, our data show that, when significant, the correlation between hormone levels and AOE activity deteriorates with age.


Exp Gerontol


Experimental gerontology


Bolzán AD,Brown OA,Goya RG,Bianchi MS




Has Abstract


1995-03-01 00:00:00














  • Immunological markers contributing to successful aging in Bulgarians.

    abstract::In order to clarify immunogenetic markers contributing to successful aging, HLA and cytokine gene profiles were analyzed in healthy elderly Bulgarians. Family segregation analysis was performed to define combined effect of haplotypes and immunophenotype profiles. The results of this study did not reveal any statistica...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Naumova E,Mihaylova A,Ivanova M,Michailova S,Penkova K,Baltadjieva D

    更新日期:2004-04-01 00:00:00

  • Innovations in Geroscience to enhance mobility in older adults.

    abstract::Aging is the primary risk factor for functional decline; thus, understanding and preventing disability among older adults has emerged as an important public health challenge of the 21st century. The science of gerontology - or geroscience - has the practical purpose of "adding life to the years." The overall goal of g...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Anton SD,Cruz-Almeida Y,Singh A,Alpert J,Bensadon B,Cabrera M,Clark DJ,Ebner NC,Esser KA,Fillingim RB,Goicolea SM,Han SM,Kallas H,Johnson A,Leeuwenburgh C,Liu AC,Manini TM,Marsiske M,Moore F,Qiu P,Mankowski RT,M

    更新日期:2020-12-01 00:00:00

  • Lifelong heterogeneity in fecundity is insufficient to explain late-life fecundity plateaus in Drosophila melanogaster.

    abstract::Previous studies have demonstrated that fecundity, like mortality, plateaus at late ages in cohorts of Drosophila melanogaster. Although evolutionary theory can explain the decline and plateau in cohort fecundity at late ages, it is conceivable that lifelong heterogeneity in individual female fecundity is producing th...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Rauser CL,Abdel-Aal Y,Shieh JA,Suen CW,Mueller LD,Rose MR

    更新日期:2005-08-01 00:00:00

  • Pleiotropic responses to methionine restriction.

    abstract::Methionine restriction (MR) extends lifespan across different species. The main responses of rodent models to MR are well-documented in adipose tissue (AT) and liver, which have reduced mass and improved insulin sensitivity, respectively. Recently, molecular mechanisms that improve healthspan have been identified in b...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Ables GP,Johnson JE

    更新日期:2017-08-01 00:00:00

  • A biochemical study of optic nerve myelin isolated by a micromethod from different aged rats.

    abstract::A micromethod was used to study myelin from individual rat optic nerves as a function of age. Protein and galactolipid content as well as 2',3'-cyclic nucleotide phosphohydrolase (CNPase) activity at ages 2, 4, 22, and 28 months were determined. Protein content increased significantly at 22 months and decreased at adv...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Jacks AS,Richardson AR,Jones MA

    更新日期:1989-01-01 00:00:00

  • Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training.

    abstract::Intrinsic exercise capacity is predictive of both lifespan and healthspan but whether adaptive exercise capacity influences the benefits achieved from aerobic training implemented later in life is not known. AIM:To determine if exercise late in life provides any functional improvements or underlying beneficial bioche...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Brown LA,Macpherson PC,Koch LG,Qi NR,Britton SL,Brooks SV

    更新日期:2019-10-01 00:00:00

  • Physiological oxygen tension is relevant to MHC-1 expression, spontaneous transformation, and interferon response of in vitro aging murine fibroblasts.

    abstract::Working from the hypothesis that modest deviations from physiological oxygen tension will influence cell characteristics important for infections/immunity and tumor development, cells were studied at three oxygen tensions during in vitro aging. Primary mouse embryo fibroblasts were established and subsequently passage...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Ebbesen P,Hager H,Aboagye-Mathiesen G,Petersen PM,Lützhøft J,Villadsen JA,Zdravkovic M,Dalsgaard AM,Zachar V

    更新日期:1993-11-01 00:00:00

  • The mitochondrial O-linked N-acetylglucosamine transferase (mOGT) in the diabetic patient could be the initial trigger to develop Alzheimer disease.

    abstract::Diabetes mellitus (DM) is considered a risk factor for the development of Alzheimer disease (AD); however, how DM favors evolution of AD is still insufficiently understood. Hyperglycemia in DM is associated to an increase in mitochondrial reactive oxygen species (ROS) generation, as well as damage of hippocampal cells...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Lozano L,Lara-Lemus R,Zenteno E,Alvarado-Vásquez N

    更新日期:2014-10-01 00:00:00

  • Neuronal and glial region dependent changes in female mice from a model of premature aging.

    abstract::Adult Premature Aging Mice (PAM) show premature immunosenescence, oxidative and inflammatory stress and consequently a shorter lifespan than Exceptional Non-Prematurely Aging Mice (E-NPAM) at the same age. Indeed, adult female PAM exhibit behavioral age-related declines and abnormalities in its brain neurochemistry. N...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Garrido A,De La Serna M,De La Fuente M,Marco EM,López-Gallardo M

    更新日期:2020-12-31 00:00:00

  • A prospective study on the association of sleep duration with grip strength among middle-aged and older Chinese.

    abstract:BACKGROUND:Longitudinal studies on sleep duration and grip strength decline are limited. This study aimed to evaluate the associations of baseline sleep duration with follow-up grip strength and grip strength changeover time among a large sample of middle-aged and older Chinese. METHODS:Data from China Health and Reti...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Wang TY,Wu Y,Wang T,Li Y,Zhang D

    更新日期:2018-03-01 00:00:00

  • The brain: a vulnerable target.

    abstract::This article addresses the description of several endocrine-related functions of the brain. It has emerged that steroids and growth factors may influence brain functions, and that brain cells may metabolize sex steroids. The crosstalk between different types of brain cells (neurons, astrocytes, the LHRH (luteinizing h...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Martini L,Melcangi RC

    更新日期:1997-07-01 00:00:00

  • Metabolic rates in genetically based long lived strains of Drosophila.

    abstract::The goal of these experiments was to determine if the increased longevity characteristics of our genetically selected long lived line of Drosophila could be attributed to metabolic differences. The data shows an inverse relationship between life span and temperature for both the long lived (L) and normal (R) strains; ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Arking R,Buck S,Wells RA,Pretzlaff R

    更新日期:1988-01-01 00:00:00

  • Repletion of antioxidant status by EGCG and retardation of oxidative damage induced macromolecular anomalies in aged rats.

    abstract::Ageing is defined as the loss of ability to maintain cellular homeostasis of an organism associated with the free radical-elicited oxidative damage to cellular macromolecules. The aim of this study was to evaluate the efficacy of epigallocatechin-3-gallate (EGCG), the key component of green tea catechins on attenuatin...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Senthil Kumaran V,Arulmathi K,Srividhya R,Kalaiselvi P

    更新日期:2008-03-01 00:00:00

  • Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa.

    abstract:OBJECTIVE:Mitochondria produce cellular energy via oxidative phosphorylation (OXPHOS), mediated by respiratory chain complexes I to IV and ATP synthase (complex V). Mitochondrial respiratory complexes have been shown to decline with age in several tissues. As the intestinal epithelium is a tissue with a high energy dem...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Özsoy M,Zimmermann FA,Feichtinger RG,Mayr JA,Kofler B,Neureiter D,Klieser E,Schütz S,Weghuber D,Schneider AM

    更新日期:2020-07-01 00:00:00

  • Long-term evaluation of osteoarthritis sheep knee, treated with TGF-β3 and BMP-6 induced multipotent stem cells.

    abstract:BACKGROUND:Hyaline articular cartilage, which protects the bones of diarthrodial joints from forces associated with load bearing, frictions, and impacts has very limited capacities for self-repair. Over the years, the trend of treatments has shifted to regenerations and researchers have been on the quest for a lasting ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Ude CC,Shamsul BS,Ng MH,Chen HC,Ohnmar H,Amaramalar SN,Rizal AR,Johan A,Norhamdan MY,Azizi M,Aminuddin BS,Ruszymah BHI

    更新日期:2018-04-01 00:00:00

  • Mesenchymal stem cell aging.

    abstract::Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Fehrer C,Lepperdinger G

    更新日期:2005-12-01 00:00:00

  • Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle.

    abstract::Calorie restriction (CR) may affect glucose tolerance via modulation of the insulin action in skeletal muscle. The present study investigated the effect of CR initiated at middle age in rats bearing glucose intolerance, in comparison with CR at a younger age. Male F344 rats at 2.5 and 18months (mo) of age were fed ad ...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Park S,Komatsu T,Hayashi H,Yamaza H,Chiba T,Higami Y,Kuramoto K,Shimokawa I

    更新日期:2006-09-01 00:00:00

  • Graying: gerontobiology of the hair follicle pigmentary unit.

    abstract::The visual appearance of humans derives predominantly from their skin and hair color. The phylogenetically ancient biochemical [corrected] pathway underling this phenomenon is called melanogenesis and results in the production of melanin pigments in neural crest-derived melanocytes, followed by its transfer to epithel...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Tobin DJ,Paus R

    更新日期:2001-01-01 00:00:00

  • The exceptional longevity of an egg-laying mammal, the short-beaked echidna (Tachyglossus aculeatus) is associated with peroxidation-resistant membrane composition.

    abstract::The echidna Tachyglossus aculeatus is a monotreme mammal from Australia that is exceptionally long-living. Its documented maximum lifespan of 50 years is 3.7 times that predicted from its body mass. Other exceptionally long-living mammals (naked mole-rats and humans) are known to have peroxidation-resistant membrane c...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Hulbert AJ,Beard LA,Grigg GC

    更新日期:2008-08-01 00:00:00

  • The sites and topology of mitochondrial superoxide production.

    abstract::Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites of superoxide production in mammalian mitochondria are known and widely accepted. In descending order of maximum capacity they are the ubiq...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Brand MD

    更新日期:2010-08-01 00:00:00

  • Does a retrograde response in human aging and longevity exist?

    abstract::The retrograde response (RR) is a compensatory mechanism by which mutant strains of yeast are able to cope with mitochondrial DNA (mtDNA) impairments by up-regulating the expression of the stress-responder nuclear genes and significantly increasing lifespan. Starting from the observation that both mtDNA variability an...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: De Benedictis G,Carrieri G,Garasto S,Rose G,Varcasia O,Bonafè M,Franceschi C,Jazwinski SM

    更新日期:2000-09-01 00:00:00

  • In vitro models of age-related neurodegenerative disorders.

    abstract::Aging is the major risk factor for numerous brain diseases. This is especially true for Alzheimer's disease (AD), a peculiar neurodegenerative disorder in that it results from the synergy of two simultaneous but distinct degenerating processes: A beta and tau pathologies. For AD, and for most neurodegenerative disorde...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,评审


    authors: Delacourte A,Sergeant N,Buée L

    更新日期:2003-11-01 00:00:00

  • Weakness, SR function and stress in gastrocnemius muscles of aged male rats.

    abstract::Aging is associated with a decline in muscle force that exceeds loss of muscle mass, suggesting that factors other than sarcopenia affect age-related muscle weakness. Here, we investigate in situ muscle force and sarcoplasmic reticulum (SR) properties in gastrocnemius muscles of adult (6-8 months) and aged (24 months)...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Russ DW,Wills AM,Boyd IM,Krause J

    更新日期:2014-02-01 00:00:00

  • Does dietary restriction reduce life span in male fruit-feeding butterflies?

    abstract::Male life history and resource allocation is not frequently studied in aging and life span research. Here, we verify that males of long-lived fruit-feeding butterfly species have reduced longevity on restricted diets [Beck, J., 2007. The importance of amino acids in the adult diet of male tropical rainforest butterfli...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Molleman F,Ding J,Boggs CL,Carey JR,Arlet ME

    更新日期:2009-09-01 00:00:00

  • Circulating miR-34a levels correlate with age-related hearing loss in mice and humans.

    abstract::Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages. There is no sensitive blood biomarker for diagnosis or early detection of AHL. MicroRNAs (miRNAs or miRs) are abundant and highly stable in blood, and have been recently described as powerful circula...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Pang J,Xiong H,Yang H,Ou Y,Xu Y,Huang Q,Lai L,Chen S,Zhang Z,Cai Y,Zheng Y

    更新日期:2016-04-01 00:00:00

  • A theoretical model of the evolution of actuarial senescence under environmental stress.

    abstract::Free-living organisms are exposed to a wide range of stressors, all of which can disrupt components of stress-related and detoxification physiology. The subsequent accumulation of somatic damage is widely believed to play a major role in the evolution of senescence. Organisms have evolved sophisticated physiological r...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Watson H,Cohen AA,Isaksson C

    更新日期:2015-11-01 00:00:00

  • Age-related differences in body weight loss in response to altered thyroidal status.

    abstract::To determine whether age-related differences in body weight loss in hyperthyroidism could be related to caloric intake, the body weight and food consumption of Fischer 344 male rats were monitored every other day for four weeks. Six-month-old (young) rats were compared to 16-month-old rats (intermediate age) and 25-mo...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Mooradian AD

    更新日期:1990-01-01 00:00:00

  • Orally supplemented catechin increases heme amounts and catalase activities in rat heart blood mitochondria: a comparison between middle-aged and young rats.

    abstract::Orally-administered catechin has long been known to have several beneficial effects on the mammalian host, however, the effects of orally supplemented catechin on the host through gingival tissues have not yet been established. Here, we elucidated the effects of orally supplemented catechin in the rat heart blood mito...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Cueno ME,Tamura M,Imai K,Ochiai K

    更新日期:2013-11-01 00:00:00

  • Effects of elastic band resistance training and nutritional supplementation on physical performance of institutionalised elderly--A randomized controlled trial.

    abstract:OBJECTIVES:To evaluate the effects of elastic band resistance training in combination with nutrient supplementation on muscular strength and the ability to perform mobility-related activities of daily living in older adults living in retirement care facilities. DESIGN:Randomized controlled trial, with a 6-month interv...

    journal_title:Experimental gerontology

    pub_type: 杂志文章,随机对照试验


    authors: Oesen S,Halper B,Hofmann M,Jandrasits W,Franzke B,Strasser EM,Graf A,Tschan H,Bachl N,Quittan M,Wagner KH,Wessner B

    更新日期:2015-12-01 00:00:00

  • In vitro erythrocidal activity of activated spleen cells from young and old mice.

    abstract::We have recently reported that activated mouse spleen mononuclear cells (MNCs) efficiently lyse autologous erythrocytes in vitro (Saxena and Chandrasekhar, 2000). In the present study, we have investigated erythrocyte-depleting ability (EDA) of spleen MNCs from young and old mice. Time kinetics of survival of erythroc...

    journal_title:Experimental gerontology

    pub_type: 杂志文章


    authors: Saxena RK,Adler WH

    更新日期:2000-05-01 00:00:00