Abstract：
:The effect of 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid kalium salt (Rumosol) and 3-(4-pyridyl)-1,2,4-thiotriazolyl 5-mercaptoacetic acid morpholinium salt (drug 2) on the concentration of Schiff base in myocardium of adult (10-12 months) and old (22-25 months) Wistar rats during immobilized stress were investigated. Here we show that the accumulation of Schiff base in the heart from both age groups was inhibited after injection of derivatives of 1,2,4-thiotriazolyl 5-mercaptoacetic acid prior to immobilization. Drug 2 possessed a two-fold higher pronounced capacity against Rumosol to inhibit the accumulation of Schiff base in the heart during stress. In myocardium from old rats, drug 2 decreased more effectively the stress-induced stimulation of lipid peroxidation as compared to dimethyl sulfoxide.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Davydov VV,Shvets VNdoi
10.1016/s0531-5565(01)00181-4keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
571-3issue
4eissn
0531-5565issn
1873-6815pii
S0531556501001814journal_volume
37pub_type
杂志文章abstract：:Aging-related changes to biological structures such as cardiovascular and musculoskeletal systems contribute to the development of comorbid conditions including cardiovascular disease and frailty, and ultimately lead to premature death. Although, frail older adults often demonstrate both cardiovascular and musculoskel...
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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pub_type： 杂志文章
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doi：10.1016/j.exger.2018.10.020
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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abstract：:Aging is associated with a decline in immune functions. Among them, T-cell activation is altered at several points of the signaling cascade following TCR engagement. Recent findings suggest that lipid rafts act as a platform in the initiation of T-cell activation. We have previously demonstrated that cholesterol conte...
journal_title：Experimental gerontology
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更新日期：2004-04-01 00:00:00
