Abstract:
PURPOSE:Aging changes the balance of sex hormones and causes endothelial dysfunction in the penis, both of which are important determinants of erectile dysfunction (ED). The purpose of this study was to evaluate whether exercise training could protect against erectile dysfunction by increasing serum testosterone and penile eNOS levels in aging rats. METHODS:A total of 14 young (2-month-old) and 14 middle-aged (18-month-old) Sprague Dawley rats were randomly assigned to either untrained control (young control, [YC], middle-aged control, [MC]) or endurance exercise-trained (young exercise, [YE], middle-aged exercise, [ME]) groups with seven rats per group. The exercise groups trained with treadmill running for 6 weeks. Body composition parameters (body weight, heart mass, liver mass, and testicular mass), serum sex hormone levels (testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin), endothelial function-related parameters in the penis (endothelial nitric oxide synthase [eNOS], CD31, alpha smooth muscle actin [α-SMA]), and maximal intracavernous pressure measure (ICP) and total ICP were analyzed in middle-aged rats. RESULTS:The middle-aged groups showed increased body weight, as compared with the young groups, but exercise training attenuated the aging-induced increase in body weight. The middle-aged groups had lower testicular mass compared with the young groups, but exercise training attenuated aging-induced decreases in testicular mass. Exercise training increased serum testosterone levels in both the young and middle-aged groups. However, there were no changes in the levels of luteinizing hormone, follicle-stimulating hormone, and prolactin among the groups. MC group showed decreased protein levels of p-eNOS, as compared with the YC group. However, exercise training protected against aging-induced decrease in eNOS and p-eNOS protein levels in the penis. Interestingly, exercise training also increased protein levels of α-SMA and maximal ICP in the middle-aged group. CONCLUSIONS:Exercise training has beneficial effects on erectile function in aged rats through increased testosterone production from the testis and strengthening of the cavernous endothelium with activation of eNOS. Therefore, exercise training may be a therapeutic modality for improving erectile dysfunction associated with aging.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Seo DY,Lee SR,Kwak HB,Park H,Seo KW,Noh YH,Song KM,Ryu JK,Ko KS,Rhee BD,Han Jdoi
10.1016/j.exger.2018.04.003subject
Has Abstractpub_date
2018-07-15 00:00:00pages
131-138eissn
0531-5565issn
1873-6815pii
S0531-5565(17)30820-3journal_volume
108pub_type
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journal_title:Experimental gerontology
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abstract::Alzheimer's disease (AD) is characterized by the accumulation and aggregation of misfolded proteins. The presence of misfolded proteins in the endoplasmic reticulum (ER) triggers a cellular stress response called the unfolded protein response (UPR). Previously, we have shown that the UPR is activated in AD neurons. In...
journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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abstract:OBJECTIVE:Aging has been reported to be associated with changes in immune function. Although frequent infection and the development of malignancy suggest the decline of immune function with aging, changes toward proinflammatory conditions also develop at the same time. Th17 cells are well known CD4(+) T cell subpopulat...
journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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journal_title:Experimental gerontology
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doi:10.1016/j.exger.2015.05.003
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pub_type: 杂志文章,随机对照试验
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journal_title:Experimental gerontology
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2012.05.008
更新日期:2012-08-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:Experimental gerontology
pub_type: 杂志文章
doi:10.1016/j.exger.2013.02.003
更新日期:2013-10-01 00:00:00