Abstract:
:The A3243G mutation, one of the changes of human mitochondrial DNA (mtDNA) that accumulates in cells during aging, is a useful marker for investigating the aging of cells. We measured the mutation level of the mtDNA A3243G mutation using DNAs from two different tissues (esophageal epithelium and myocardium) from advanced elderly individuals. The mean level of the A3243G mutation for the esophageal epithelium was 0.0063+/-0.0019, and that for the myocardium was 0.0098+/-0.0031. The mutation level in the myocardium was significantly higher than that in the esophageal epithelium, indicating that more mtDNA A3243G mutations accumulated in the myocardium than in the esophageal epithelium. Since the myocardium is static with respect to cell turnover, but in the esophageal epithelium renewal is very rapid, it is possible that the mtDNA A3243G mutation in the myocardium accumulates more rapidly than in the esophageal epithelium. This phenomenon may reflect the difference in the longevity of cells in each of these tissues and their different levels of oxidative stress.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Harihara S,Nakamura K,Takubo K,Takeuchi Fdoi
10.1016/s0531-5565(02)00020-7keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
917-23issue
7eissn
0531-5565issn
1873-6815pii
S0531556502000207journal_volume
37pub_type
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