Connexin 43 and ischemic preconditioning: effects of age and disease.

abstract：BACKGROUND:The World Health Organization (WHO) recently proposed an innovative model of care focusing on functional rather than disease-based perspectives, based on a construct of intrinsic capacity (IC). OBJECTIVE:This study aimed to analyze if low-grade inflammation (LGI) (chronically raised C-reactive protein - CRP...

journal_title：Experimental gerontology

authors： Giudici KV,de Souto Barreto P,Guerville F,Beard J,Araujo de Carvalho I,Andrieu S,Rolland Y,Vellas B,MAPT\/DSA group.

更新日期：2019-11-01 00:00:00

abstract：:Histopathological and autofluorescence investigations were carried out to study lipofuscin pigment accumulation in various age groups of mice. Qualitative studies revealed an increase of lipofuscin pigment accumulation in old animals. Quantitative studies showed a significant increase in the percentage of pigmented ne...

journal_title：Experimental gerontology

authors： Goyal VK

更新日期：1982-01-01 00:00:00

abstract：:Arterial stiffness, an independent predictor of cardiovascular disease, is increased in aging, but the underlying mechanisms are not completely understood. Mineralocorticoid receptors (MR) may contribute to oxidative stress and arterial stiffness in healthy older adults. To test the hypothesis that short-term MR block...

journal_title：Experimental gerontology

authors： Hwang MH,Yoo JK,Luttrell M,Kim HK,Meade TH,English M,Nichols WW,Christou DD

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:The present study investigated whether the performance on executive function tasks of patients with type 2 diabetes mellitus (T2DM) is as impaired as that of Alzheimer's disease (AD) patients and to compare their performance with that of a group of cognitively healthy older adults. We also investigated wheth...

journal_title：Experimental gerontology

authors： Redondo MT,Beltrán-Brotóns JL,Reales JM,Ballesteros S

更新日期：2016-10-01 00:00:00

abstract：:A crucial assumption of evolutionary theories of aging is that age-specific differences of life history traits may have genetic causes. The present study focuses on the existence of such differences between eight freshly caught populations of Drosophila melanogaster. A highly significant differentiation of the populat...

journal_title：Experimental gerontology

authors： Draye X,Lints FA

更新日期：1996-11-01 00:00:00

abstract：BACKGROUNDS:Elucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and intervention procedures. METHODS:We conducted two-stage time-to-event Mendelian randomization meta-analyses combining five large-scale longitudinal cohorts ...

journal_title：Experimental gerontology

authors： He L,Culminskaya I,Loika Y,Arbeev KG,Bagley O,Duan M,Yashin AI,Kulminski AM

更新日期：2018-07-01 00:00:00

abstract：:A decline in instrumental activities of daily living has been described as the earliest functional deficit in patients with neurodegenerative disease. It embraces specific competencies such as: "recalling the date and telephone calls, orienting to new places, remembering the location of objects at home, understanding ...

journal_title：Experimental gerontology

authors： Amanzio M,D'Agata F,Palermo S,Rubino E,Zucca M,Galati A,Pinessi L,Castellano G,Rainero I

更新日期：2016-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) are formed in all living organisms as a by-product of normal metabolism (endogenous sources) and as a consequence of exposure to environmental compounds (exogenous sources). Endogenous ROS are largely formed during oxidative phosphorylation in the mitochondria and, therefore, mitochondria...

journal_title：Experimental gerontology

authors： Stevnsner T,Thorslund T,de Souza-Pinto NC,Bohr VA

更新日期：2002-10-01 00:00:00

abstract：:The effect of aging was tested on experimental ventricular arrhythmias in isolated heart preparations from normal Wistar rats (NWR), Wistar Kyoto rats (WKY), and spontaneously hypertensive rats (SHR). Delayed afterdepolarizations and triggered activity induced by high-calcium perfusion (16 mM) in isolated papillary mu...

journal_title：Experimental gerontology

authors： Carbonin PU,Di Gennaro M,Pahor M,Bernabei R,Sgadari A,Gambassi G Jr

更新日期：1990-01-01 00:00:00

abstract：:Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohy...

journal_title：Experimental gerontology

authors： Bruce KD,Hoxha S,Carvalho GB,Yamada R,Wang HD,Karayan P,He S,Brummel T,Kapahi P,Ja WW

更新日期：2013-10-01 00:00:00

abstract：:The intrinsic contractile properties of papillary muscles isolated from female Wistar rats during post-natal development were examined. In addition, the myocardial responsiveness to certain inotropic interventions was studied. In muscles from 60-day-old animals, the velocity of shortening was markedly greater than mus...

journal_title：Experimental gerontology

authors： Capasso JM,Sonnenblick EH

更新日期：1982-01-01 00:00:00

abstract：:There are three general categories of causes of the cognitive decline associated with aging: disuse, disease, and aging per se. People tend to use certain skills or abilities less with age and, thus, those skills decline due to the disuse. Physical illnesses tend to increase with age, which will tend to compromise cog...

journal_title：Experimental gerontology

authors： Zec RF

更新日期：1995-05-01 00:00:00

abstract：:As recently reported, it is possible to detect and quantify the amount of the deleted human mitochondrial DNA (mtDNA) in whole blood, platelets and peripheral blood mononuclear cells using real-time PCR. The aim of this study was to identify the cell types in human blood carrying the 4977 bp deleted mtDNA and their ac...

journal_title：Experimental gerontology

authors： Mohamed SA,Wesch D,Blumenthal A,Bruse P,Windler K,Ernst M,Kabelitz D,Oehmichen M,Meissner C

更新日期：2004-02-01 00:00:00

abstract：:In young mice exposed to aerosol infection with Mycobacterium tuberculosis removal of the gammadelta T cell population by targeted gene disruption does not affect the expression of host resistance, but does influence the integrity of the early granulomatous response. The current study demonstrates that in aged gammade...

journal_title：Experimental gerontology

authors： Turner J,Frank AA,Brooks JV,Marietta PM,Vesosky B,Orme IM

更新日期：2001-02-01 00:00:00

abstract：:Skeletal muscle atrophy reduces quality of life and increases morbidity and mortality in patients with chronic conditions. Oxidative stress is a key factor contributing to skeletal muscle atrophy by altering both protein synthesis and protein degradation pathways. Beta-lapachone (Beta-L) is known to act as a pro-oxida...

journal_title：Experimental gerontology

authors： Park S,Shin MG,Kim JR,Park SY

更新日期：2019-10-15 00:00:00

abstract：:Melatonin, the main product synthesized by the pineal gland, modulates several brain functions through different mechanisms, some of them involving the activation or participation of calcium binding intracellular proteins, such as the alpha calcium dependent protein kinase C and calmodulin. Another calcium-binding pro...

journal_title：Experimental gerontology

authors： Ramírez-Rodríguez G,Gómez-Sánchez A,Ortíz-López L

更新日期：2014-12-01 00:00:00

abstract：:Plantar-flexor muscles are key muscles in the control of postural sway. Older fallers present lower maximal plantar-flexor performance than older non-fallers; however, the mechanisms underlying this motor impairment remain to be elucidated. This study aimed to determine whether muscular and neural factors are both inv...

journal_title：Experimental gerontology

authors： Cattagni T,Harnie J,Jubeau M,Hucteau E,Couturier C,Mignardot JB,Deschamps T,Berrut G,Cornu C

更新日期：2018-10-02 00:00:00

abstract：:Histological surveys of the hearts of guppies Poecilia reticulatus throughout their lifespan showed no aging changes until the fish were three years old. In younger fishes the hearts were healthy, even in three individuals with "wasting" disease, where there was considerable loss of muscle throughout the body. There w...

journal_title：Experimental gerontology

authors： Woodhead AD

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Sarcopenic obesity is a combination of both sarcopenia and obesity, which potentiate each other and maximize the negative influences of each, such as physical disability, morbidity, or even mortality. OBJECTIVES:To describe the criteria used to identify people with sarcopenic obesity and the components of t...

journal_title：Experimental gerontology

authors： Yin YH,Liu JYW,Välimäki M

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Aging leads to poorer neuromuscular control that may impact mobility. However, the specific decades when these changes occur, and whether these time-based changes are sex-specific, are unclear. METHODS:Adults aged 20-82 years (N = 93, 51 females) walked six gait trials at their preferred speed over a 10-m...

journal_title：Experimental gerontology

authors： Bailey CA,Corona F,Pilloni G,Porta M,Fastame MC,Hitchcott PK,Penna MP,Pau M,Côté JN

更新日期：2018-09-01 00:00:00

abstract：:Age-related bone loss is thought to be due to impaired osteoblast functions. Insulin-like growth factors (IGFs) have been shown to be important stimulators of bone formation and osteoblast activities in vitro and in vivo. We tested the hypothesis that in vitro osteoblast senescence is associated with changes in compon...

journal_title：Experimental gerontology

authors： Kveiborg M,Flyvbjerg A,Rattan SI,Kassem M

更新日期：2000-10-01 00:00:00

abstract：:Atrophy of the thymus, the primary site of T lymphocyte generation, is a hallmark of the aging immune system. Age-associated thymic atrophy results in diminished output of new, naïve T cells, with immune sequelae that include diminished responses to novel pathogenic challenge and vaccines, as well as diminished tumor ...

journal_title：Experimental gerontology

authors： Cepeda S,Griffith AV

更新日期：2018-05-01 00:00:00

abstract：:Diabetes mellitus (DM) is considered a risk factor for the development of Alzheimer disease (AD); however, how DM favors evolution of AD is still insufficiently understood. Hyperglycemia in DM is associated to an increase in mitochondrial reactive oxygen species (ROS) generation, as well as damage of hippocampal cells...

journal_title：Experimental gerontology

authors： Lozano L,Lara-Lemus R,Zenteno E,Alvarado-Vásquez N

更新日期：2014-10-01 00:00:00

abstract：:Recently, it has been suggested that oxytocin (OT) might play a role in the control of bone remodeling and in bone health of young and adult females. The purpose of this study was to evaluate the effect of osteogenic medium (OM) plus OT (OM + OT; 100 nmol/L) on osteoblastic differentiation of bone marrow mesenchymal s...

journal_title：Experimental gerontology

authors： Santos LF,Singulani MP,Stringhetta-Garcia CT,Oliveira SHP,Chaves-Neto AH,Dornelles RCM

更新日期：2018-11-01 00:00:00

abstract：:Osteoporosis is extremely frequent in post-menopausal women; nevertheless, osteoporosis in men is also a severe and frequently occurring but often underestimated disease. Increasing evidence links bone loss in male idiopathic osteoporosis and age related osteoporosis to osteoblast dysfunction rather than increased ost...

journal_title：Experimental gerontology

authors： Föger-Samwald U,Patsch JM,Schamall D,Alaghebandan A,Deutschmann J,Salem S,Mousavi M,Pietschmann P

更新日期：2014-09-01 00:00:00

abstract：:Estrogen replacement therapy (ERT) seems to enhance longevity in women. Both gender and aging have been shown to influence the regulation of circadian rhythms, yet little is known about the effect of ERT on circadian regulation. The aim of this study was to determine the effects of ERT (oral conjugated estrogen: Prema...

journal_title：Experimental gerontology

authors： Gudmundsson A,Goodman B,Lent S,Barczi S,Grace A,Boyle L,Ershler WB,Carnes M

更新日期：1999-09-01 00:00:00

abstract：:The binding of advanced glycation endproducts (AGEs) to their receptors is known to cause changes in cell function during normal ageing and is implicated in the pathogenesis of cardiovascular disease. In this study, expression of the AGE-receptor 3 (AGE-R3) and the receptor for AGEs (RAGE) was compared on the mRNA and...

journal_title：Experimental gerontology

authors： Simm A,Casselmann C,Schubert A,Hofmann S,Reimann A,Silber RE

更新日期：2004-03-01 00:00:00

abstract：:Changes associated with the age-related decline of physiological functions, and their relation with mortality rates, are thoroughly being investigated in the aging research field. We used the Mediterranean fruit fly Ceratitis capitata, largely studied by biodemographers, as a model for functional senescence studies. T...

journal_title：Experimental gerontology

authors： Pujol-Lereis LM,Rabossi A,Quesada-Allué LA

更新日期：2012-06-01 00:00:00

abstract：:The ascorbic acid content of Drosophila melanogaster was found to be high in the absence of a dietary source. The amount of ascorbic acid per fly declined with aging in both the Oregon R and Swedish C strains. The median life span at 25 degrees C was 45 days for Swedish C and 59 days for Oregon R. The amount of ascorb...

journal_title：Experimental gerontology

authors： Massie HR,Shumway ME,Whitney SJ,Sternick SM,Aiello VR

更新日期：1991-01-01 00:00:00

abstract：:A summary of the Eleventh International Symposium on the Neurobiology and Neuroendocrinology of Aging that was held in July 29-August 3 in Bregenz, Austria, is presented. Sixteen of the speakers who presented at the conference submitted review papers covering the topic of their presentation as well as an overview of t...

journal_title：Experimental gerontology

authors： Brown-Borg HM,Borg KE

更新日期：2013-07-01 00:00:00