Abstract：
:Werner's syndrome is a premature aging syndrome with many features common to normal aging. The possible association between phenotypic markers for normal aging and SNP's in the WRN gene was investigated in 426 dizygotic, Danish twins age 70-90 years. All participants were scored every second year using a number of physical and cognitive tests. In addition their self-rated health was registered as well as self reported status with regards to nine diseases. Blood was drawn from all participants and purified DNA was typed for four SNP's in the WRN gene. The four SNP's were located in intron 1, exon 6, exon 9 and exon 34. In an unpaired analysis of this material a significant association between the intron 1 SNP and cognitive function was demonstrated. Our finding, which will need corroboration in independent samples, therefore may suggest that the t-allele of the intron 1 SNP is beneficial to cognitive function. However, since the t-allele of this SNP is very rare, we did not encounter any tt-homozygous individuals for this allele.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Bendixen MH,Nexø BA,Bohr VA,Frederiksen H,McGue M,Kølvraa S,Christensen Kdoi
10.1016/j.exger.2004.03.036keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
1101-7issue
7eissn
0531-5565issn
1873-6815pii
S0531556504001408journal_volume
39pub_type
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journal_title：Experimental gerontology
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doi：10.1016/j.exger.2009.08.004
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doi：10.1016/s0531-5565(03)00101-3
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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abstract：:The Tokyo Metropolitan Institute of Gerontology (TMIG) celebrates its 30th anniversary in 2002. Since its establishment, TMIG has been carrying out inter-disciplinary research on aging as a core institute in Japan and functions as a knowledge bank and a source for capable researchers of gerontology. The proportion of ...
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
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journal_title：Experimental gerontology
pub_type： 杂志文章,评审
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