Differential gene expression in the nucleus accumbens and frontal cortex of lewis and Fischer 344 rats relevant to drug addiction.

abstract：:Amphetamines exert their persistent addictive effects by activating brain's reward pathways, perhaps through the release of dopamine in the nucleus accumbens (and/or in other places). On the other hand, there is a relationship between dopamine and all behavioural aspects that involve motor activity and it has been dem...

journal_title：Current neuropharmacology

authors： Fontes-Ribeiro CA,Marques E,Pereira FC,Silva AP,Macedo TR

更新日期：2011-03-01 00:00:00

abstract：:Animal behavioural profiles are commonly employed to investigate new therapeutic agents to treat anxiety disorders as well as to investigate the mechanism of action of anxiolytic drugs. However, many clinically important symptoms of anxiety can not be modelled directly in animals. Human models of anxiety should bridge...

journal_title：Current neuropharmacology

authors： Siepmann M,Joraschky P

更新日期：2007-03-01 00:00:00

abstract：:Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as m...

journal_title：Current neuropharmacology

authors： Luo J,Walters ET,Carlton SM,Hu H

更新日期：2013-12-01 00:00:00

abstract：:Alzheimer's disease is one of the most progressive forms of dementia, ultimately leading to death in aged populations. The major hallmarks of Alzheimer's disease include deposition of extracellular amyloid senile plaques and intracellular neurofibrillary tangles in brain neuronal cells. Although there are classical th...

journal_title：Current neuropharmacology

authors： Singh RK

更新日期：2020-01-01 00:00:00

abstract：:MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway,...

journal_title：Current neuropharmacology

authors： Takamatsu Y,Shiotsuki H,Kasai S,Sato S,Iwamura T,Hattori N,Ikeda K

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Over 100 people die daily from opioid overdose and $78.5B per year is spent on treatment efforts, however, the real societal cost is multifold greater. Alternative strategies to eradicate/manage drug misuse and addiction need consideration. The perception of opioid addiction as a social/criminal problem has ...

journal_title：Current neuropharmacology

authors： Abijo T,Blum K,Gondré-Lewis MC

更新日期：2020-01-01 00:00:00

abstract：:Ketamine is a noncompetitive antagonist of the NMDA-receptors, used as a dissociative anesthetic, presently included in the category of the psychoactive substances known as "club drugs". Ketamine administration was associated with impaired working memory and increased psychopathological symptoms, but there is a lack o...

journal_title：Current neuropharmacology

authors： Venâncio C,Magalhães A,Antunes L,Summavielle T

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Depression is among the commonest of psychiatric disorders, and inflammatory mechanisms have been suggested to play a role in its pathophysiology. Interferons are a superfamily of proinflammatory cytokines that play a role in host defence mechanisms. Interferons are used in the treatment of a variety of auto...

journal_title：Current neuropharmacology

authors： Pinto EF,Andrade C

更新日期：2016-01-01 00:00:00

abstract：:Tissue plasminogen activator (t-PA) is the only FDA-approved drug for acute ischemic stroke treatment, but its clinical use is limited due to the narrow therapeutic time window and severe adverse effects, including hemorrhagic transformation (HT) and neurotoxicity. One of the potential resolutions is to use adjunct th...

journal_title：Current neuropharmacology

authors： Chen HS,Qi SH,Shen JG

更新日期：2017-01-01 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are two distinct forms of synaptic plasticity that have been extensively characterized at the Schaffer collateral-CA1 (SCCA1) synapse and the mossy fiber (MF)-CA3 synapse within the hippocampus, and are postulated to be the molecular underpinning for several ...

journal_title：Current neuropharmacology

authors： Senter RK,Ghoshal A,Walker AG,Xiang Z,Niswender CM,Conn PJ

更新日期：2016-01-01 00:00:00

abstract：:Glutamate receptor, ionotropic, N-methyl-D-aspartate associated protein 1 (GRINA) is a member of the NMDA receptors (NMDARs) and is involved in several neurological diseases, which governs the key processes of neuronal cell death or the release of neurotransmitters. Upregulation of GRINA has been reported in multiple ...

journal_title：Current neuropharmacology

authors： Chen K,Yang LN,Lai C,Liu D,Zhu LQ

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) constitutes the primary reason for mortality and morbidity in persons worldwide below 45 years of age. 1.7 million Traumatic events occur yearly in the United States alone, considering for 50,000 deaths. In severe traumatic brain injury sufferers, a considerable achievement attai...

journal_title：Current neuropharmacology

authors： Kaur P,Sharma S

更新日期：2018-01-01 00:00:00

abstract：:Over the last decades, the scientific interest in chemistry and pharmacology of cannabinoids has increased. Most attention has focused on ∆(9)-tetrahydrocannabinol (∆(9)-THC) as it is the psychoactive constituent of Cannabis sativa (C. sativa). However, in previous years, the focus of interest in the second plant cons...

journal_title：Current neuropharmacology

authors： Murillo-Rodríguez E,Sarro-Ramírez A,Sánchez D,Mijangos-Moreno S,Tejeda-Padrón A,Poot-Aké A,Guzmán K,Pacheco-Pantoja E,Arias-Carrión O

更新日期：2014-05-01 00:00:00

abstract：:As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery o...

journal_title：Current neuropharmacology

authors： Murray AP,Faraoni MB,Castro MJ,Alza NP,Cavallaro V

更新日期：2013-07-01 00:00:00

abstract：:The 'omnipresence' of adenosine in all nervous system cells (neurons and glia) together with the intensive release of adenosine following insults, makes adenosine as a sort of 'maestro' of synapses leading to the homeostatic coordination of brain function. Besides direct actions of adenosine on the neurosecretory mech...

journal_title：Current neuropharmacology

authors： Sebastião AM,Ribeiro JA

更新日期：2009-09-01 00:00:00

abstract：:Liver failure can lead to generalized hyperammonemia, which is thought to be the underlying cause of hepatic encephalopathy. This neuropsychiatric syndrome is accompanied by functional changes of astrocytes. These glial cells enter ammonia-induced self-amplifying cycle characterized by brain oedema, oxidative and osmo...

journal_title：Current neuropharmacology

authors： Montana V,Verkhratsky A,Parpura V

更新日期：2014-07-01 00:00:00

abstract：:Many issues remain unresolved about antipsychotic drugs. Their therapeutic potency scales with affinity for dopamine D2 receptors, but there are indications that they act indirectly, with dopamine D1 receptors (and others) as possible ultimate targets. Classical neuroleptic drugs disinhibit striatal cholinergic intern...

journal_title：Current neuropharmacology

authors： Miller R

更新日期：2009-12-01 00:00:00

abstract：:New psychoactive substances (NPS) have completely modified the drug scene and the current landscape of addiction. Synthetic substances, such as substituted or synthetic cathinones, also known as « legal highs », are often produced and used to mimic the effects of controlled drugs such as cocaine, methylenedioxymethamp...

journal_title：Current neuropharmacology

authors： Karila L,Megarbane B,Cottencin O,Lejoyeux M

更新日期：2015-01-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are i...

journal_title：Current neuropharmacology

authors： Zoli M,Pucci S,Vilella A,Gotti C

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Diabetic retinopathy (DR) is an important complication of diabetes and is considered one of the main causes of blindness in moderate-income and highly-developed countries. As it is a major socioeconomic problem, defining all mechanisms that may lead to DR development is of great importance. In the 21st centu...

journal_title：Current neuropharmacology

authors： Mrugacz M,Bryl A,Bossowski A

更新日期：2016-01-01 00:00:00

abstract：:Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome (CFS) has been classified as a disease of the central nervous system by the WHO since 1969. Many patients carrying this diagnosis do demonstrate an almost bewildering array of biological abnormalities particularly the presence of oxidative and nitrosative stres...

journal_title：Current neuropharmacology

authors： Morris G,Maes M

更新日期：2014-03-01 00:00:00

abstract：:The transient receptor potential (TRP) proteins are a family of ion channels that act as cellular sensors. Several members of the TRP family are sensitive to oxidative stress mediators. Among them, TRPA1 is remarkably susceptible to various oxidants, and is known to mediate neuropathic pain and respiratory, vascular a...

journal_title：Current neuropharmacology

authors： Kozai D,Sakaguchi R,Ohwada T,Mori Y

更新日期：2015-01-01 00:00:00

abstract：:During the past decades Neural Stem Cells have been considered as an alternative source of cells to replace lost neurons and NSC transplantation has been indicated as a promising treatment for neurodegenerative disorders. Nevertheless, the current understanding of NSC biology suggests that, far from being mere spare p...

journal_title：Current neuropharmacology

authors： Carletti B,Piemonte F,Rossi F

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Congenital myasthenic syndromes (CMSs) are a heterogeneous group of neuromuscular disorders. Mutations of the nicotinic acetylcholine receptor epsilon subunit gene (CHRNE) are the most common causes of these disorders. CMSs are gaining increasing recognition by clinicians. However, pharmacological treatment ...

journal_title：Current neuropharmacology

authors： Huang K,Luo YB,Bi FF,Yang H

更新日期：2020-07-28 00:00:00

abstract：:Metabotropic glutamate (mGlu) receptors represent the largest family of glutamate receptors in mammals and act as fine tuners of the chemical transmission in central nervous system (CNS). In the last decade, results concerning the expression and the subcellular localization of mGlu receptors further clarified their ro...

journal_title：Current neuropharmacology

authors： Olivero G,Vergassola M,Cisani F,Roggeri A,Pittaluga A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucid...

journal_title：Current neuropharmacology

authors： Marichal-Cancino BA,Fajardo-Valdez A,Ruiz-Contreras AE,Mendez-Díaz M,Prospero-García O

更新日期：2017-01-01 00:00:00

abstract：:Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often life-threatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR)...

journal_title：Current neuropharmacology

authors： González-Maeso J,Meana JJ

更新日期：2006-04-01 00:00:00

abstract：:In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimer's disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acety...

journal_title：Current neuropharmacology

authors： Chen S,Zhang XJ,Li L,Le WD

更新日期：2007-01-01 00:00:00

abstract：:Depression is a serious psychiatric illness that affects millions of people worldwide. Weeks of antidepressant therapy are required to relieve depressive symptoms, and new drugs are still being extensively researched. The latest studies have shown that in depression, there is an imbalance between the main excitatory (...

journal_title：Current neuropharmacology

authors： Mlyniec K

更新日期：2015-01-01 00:00:00

abstract：:Brain and spinal cord injuries present significant therapeutic challenges. The treatments available for these conditions are largely ineffective, partly due to limitations in directly targeting the therapeutic agents to sites of pathology within the central nervous system (CNS). The use of stem cells to treat these co...

journal_title：Current neuropharmacology

authors： Azari MF,Mathias L,Ozturk E,Cram DS,Boyd RL,Petratos S

更新日期：2010-12-01 00:00:00