Abstract:
:Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are involved in a variety of physiological and pathophysiological processes. Numerous studies have shown that the expression and/or function of nAChRs is compromised in many neurological and psychiatric diseases. Furthermore, recent studies have shown that neuronal nAChRs are found in a large number of nonneuronal cell types including endothelial cells, glia, immune cells, lung epithelia and cancer cells where they regulate cell differentiation, proliferation and inflammatory responses. The aim of this review is to describe the most recent findings concerning the structure and function of native nAChRs inside and outside the nervous system.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Zoli M,Pucci S,Vilella A,Gotti Cdoi
10.2174/1570159X15666170912110450subject
Has Abstractpub_date
2018-01-01 00:00:00pages
338-349issue
4eissn
1570-159Xissn
1875-6190pii
CN-EPUB-85716journal_volume
16pub_type
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