One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke.

abstract：:Over the last decades, the scientific interest in chemistry and pharmacology of cannabinoids has increased. Most attention has focused on ∆(9)-tetrahydrocannabinol (∆(9)-THC) as it is the psychoactive constituent of Cannabis sativa (C. sativa). However, in previous years, the focus of interest in the second plant cons...

journal_title：Current neuropharmacology

authors： Murillo-Rodríguez E,Sarro-Ramírez A,Sánchez D,Mijangos-Moreno S,Tejeda-Padrón A,Poot-Aké A,Guzmán K,Pacheco-Pantoja E,Arias-Carrión O

更新日期：2014-05-01 00:00:00

abstract：:The heat shock protein (Hsp) family is an evolutionarily conserved system that is charged with preventing unfolded or misfolded proteins in the cell from aggregating. In Alzheimer's disease, extracellular accumulation of the amyloid β peptide (Aβ) and intracellular aggregation of the microtubule associated protein tau...

journal_title：Current neuropharmacology

authors： Abisambra JF,Jinwal UK,Jones JR,Blair LJ,Koren J 3rd,Dickey CA

更新日期：2011-12-01 00:00:00

abstract：:Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorders. Why these aggregates form remains unclear. Equally debated is whether they are toxic, protective, or simple by-products. Increasing evidence, however, supports the notion that in general aggregates confer toxicity a...

journal_title：Current neuropharmacology

authors： Bossy B,Perkins G,Bossy-Wetzel E

更新日期：2008-06-01 00:00:00

abstract：:The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, an...

journal_title：Current neuropharmacology

authors： Ferrucci M,Giorgi FS,Bartalucci A,Busceti CL,Fornai F

更新日期：2013-01-01 00:00:00

abstract：:Although originally proposed as a subtype of opioid receptors, the sigma receptor is now confirmed to be a non-opioid receptor that binds diverse classes of psychotropic drugs. Sigma receptors are subdivided into two subtypes, sigma-1 and sigma-2. The sigma-1 receptor is a 25-kDa protein possessing one putative transm...

journal_title：Current neuropharmacology

authors： Hayashi T,Su T

更新日期：2005-10-01 00:00:00

abstract：:The acronym TBI refers to traumatic brain injury, an alteration of brain function, or an evidence of brain pathology, that is caused by an external force. TBI is estimated to become the third leading cause of permanent disability and mortality worldwide. TBI-related injuries can be classified in many ways, according t...

journal_title：Current neuropharmacology

authors： Pinchi E,Frati P,Arcangeli M,Volonnino G,Tomassi R,Santoro P,Cipolloni L

更新日期：2020-01-01 00:00:00

abstract：:Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins: the Aquaporins (AQPs). These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in ...

journal_title：Current neuropharmacology

authors： Buffoli B

更新日期：2010-06-01 00:00:00

abstract：:Pediatric Bipolar Disorder (BD) is a highly morbid pediatric psychiatric disease, consistently associated with family psychiatric history of mood disorders and associated with high levels of morbidity and disability and with a great risk of suicide. While there is a general consensus on the symptomatology of depressio...

journal_title：Current neuropharmacology

authors： Serra G,Uchida M,Battaglia C,Casini MP,De Chiara L,Biederman J,Vicari S,Wozniak J

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The concept of food addiction attracts much interest in the scientific community. Research is mainly based on the Yale Food Addiction Scale (YFAS), a tool developed to assess food addiction. Substance use disorder criteria have been used to develop this scale. OBJECTIVE:The aim of this paper was to review t...

journal_title：Current neuropharmacology

authors： Penzenstadler L,Soares C,Karila L,Khazaal Y

更新日期：2019-01-01 00:00:00

abstract：:The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought to serve as a key relay connecting limbic forebrain structures to hypothalamic and brainstem reg...

journal_title：Current neuropharmacology

authors： Crestani CC,Alves FH,Gomes FV,Resstel LB,Correa FM,Herman JP

更新日期：2013-03-01 00:00:00

abstract：:Eicosanoids are arachidonic acid (AA) derivatives belonging to a family of lipid signalling mediators that are engaged in both physiological and pathological processes in the brain. Recently, their implication in the prolonged inflammatory response has become a focus of particular interest because, in contrast to acut...

journal_title：Current neuropharmacology

authors： Regulska M,Szuster-Głuszczak M,Trojan E,Leśkiewicz M,Basta-Kaim A

更新日期：2021-01-01 00:00:00

abstract：:When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clini...

journal_title：Current neuropharmacology

authors： Smith BJ,St Louis EK,Stern JM,Green C,Bramley T

更新日期：2009-06-01 00:00:00

abstract：:MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway,...

journal_title：Current neuropharmacology

authors： Takamatsu Y,Shiotsuki H,Kasai S,Sato S,Iwamura T,Hattori N,Ikeda K

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Diabetic retinopathy (DR) is an important complication of diabetes and is considered one of the main causes of blindness in moderate-income and highly-developed countries. As it is a major socioeconomic problem, defining all mechanisms that may lead to DR development is of great importance. In the 21st centu...

journal_title：Current neuropharmacology

authors： Mrugacz M,Bryl A,Bossowski A

更新日期：2016-01-01 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are two distinct forms of synaptic plasticity that have been extensively characterized at the Schaffer collateral-CA1 (SCCA1) synapse and the mossy fiber (MF)-CA3 synapse within the hippocampus, and are postulated to be the molecular underpinning for several ...

journal_title：Current neuropharmacology

authors： Senter RK,Ghoshal A,Walker AG,Xiang Z,Niswender CM,Conn PJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is widely expressed in cells of the immune system such as T- and B-lymphocytes, mast cells, macrophages and microglia, but also found in dedifferentiated vascular smooth muscle cells, fibroblasts and many cancer cells including pancreatic, prostat...

journal_title：Current neuropharmacology

authors： Brown BM,Pressley B,Wulff H

更新日期：2018-01-01 00:00:00

abstract：:Temozolomide (TMZ), an oral alkylating prodrug which delivers a methyl group to purine bases of DNA (O6- guanine; N7-guanine and N3-adenine), is frequently used together with radiotherapy as part of the first-line treatment of high-grade gliomas. The main advantages are its high oral bioavailability (almost 100% altho...

journal_title：Current neuropharmacology

authors： Ortiz R,Perazzoli G,Cabeza L,Jiménez-Luna C,Luque R,Prados J,Melguizo C

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Shared connections between physical activity and neuroprotection have been studied for decades, but the mechanisms underlying this effect of specific exercise were only recently brought to light. Several evidences suggest that physical activity may be a reasonable and beneficial method to improve functional ...

journal_title：Current neuropharmacology

authors： Cobianchi S,Arbat-Plana A,Lopez-Alvarez VM,Navarro X

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Hereditary cerebellar ataxias are a group of disorders characterized by heterogeneous clinical manifestations, progressive clinical course, and diverse genetic causes. No disease modifying treatments are yet available for many of these disorders. Oxidative stress has been recurrently identified in different ...

journal_title：Current neuropharmacology

authors： Barca E,Emmanuele V,DiMauro S,Toscano A,Quinzii CM

更新日期：2019-01-01 00:00:00

abstract：:Migraine, an extremely disabling neurological disorder, has a strong genetic component. Since monogenic migraines (resulting from mutations or changes in a single gene) may help researchers discover migraine pathophysiology, transgenic mice models harboring gene mutations identified in Familial Hemiplegic Migraine (FH...

journal_title：Current neuropharmacology

authors： Dehghani A,Karatas H

更新日期：2019-01-01 00:00:00

abstract：:During the last decade, several meta-analytic studies employing different methodological approaches have had inconsistent conclusions regarding antidepressant efficacy. Herein, we aim to comment on methodological aspects that may have contributed to disparate findings. We initially discuss methodological inconsistenci...

journal_title：Current neuropharmacology

authors： Fountoulakis KN,McIntyre RS,Carvalho AF

更新日期：2015-01-01 00:00:00

abstract：:Changes of the tumor necrosis factor-alpha (TNF-alpha) system have been shown to be involved in the development of psychiatric disorders and are additionally associated with changes in body weight as well as endocrine and metabolic changes in psychiatric patients. TNF-alpha might, for example, contribute to the pathog...

journal_title：Current neuropharmacology

authors： Berthold-Losleben M,Himmerich H

更新日期：2008-09-01 00:00:00

abstract：:In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimer's disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acety...

journal_title：Current neuropharmacology

authors： Chen S,Zhang XJ,Li L,Le WD

更新日期：2007-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is the principal cause of invalidity and death in the population under 45 years of age worldwide. This mini-review aims to systematize the forensic approach in neuropathological studies, highlighting the proper elements to be noted during external, radiological, autoptical, and histologica...

journal_title：Current neuropharmacology

authors： Bertozzi G,Maglietta F,Sessa F,Scoto E,Cipolloni L,Di Mizio G,Salerno M,Pomara C

更新日期：2020-01-01 00:00:00

abstract：:Animal behavioural profiles are commonly employed to investigate new therapeutic agents to treat anxiety disorders as well as to investigate the mechanism of action of anxiolytic drugs. However, many clinically important symptoms of anxiety can not be modelled directly in animals. Human models of anxiety should bridge...

journal_title：Current neuropharmacology

authors： Siepmann M,Joraschky P

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. METHODS:A homology model of the transmembrane and extracellular regions of an Anophele...

journal_title：Current neuropharmacology

authors： Vinekar RS,Sowdhamini R

更新日期：2017-11-14 00:00:00

abstract：:The calcium (Ca(2+))-sensing receptor (CaR) belongs to family C of the G-protein coupled receptors (GPCRs). The receptor is activated by physiological levels of Ca(2+) (and Mg(2+)) and positively modulated by a range of proteinogenic L-alpha-amino acids. Recently, several synthetic allosteric modulators of the recepto...

journal_title：Current neuropharmacology

authors： Jensen AA,Bräuner-Osborne H

更新日期：2007-09-01 00:00:00

abstract：:Ion channels are complex transmembrane proteins that orchestrate the electrical signals necessary for normal function of excitable tissues, including the central nervous system, peripheral nerve, and both skeletal and cardiac muscle. Progress in molecular biology has allowed cloning and expression of genes that encode...

journal_title：Current neuropharmacology

authors： Kleopa KA

更新日期：2011-09-01 00:00:00

abstract：:Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as m...

journal_title：Current neuropharmacology

authors： Luo J,Walters ET,Carlton SM,Hu H

更新日期：2013-12-01 00:00:00

abstract：:Malignant glioma is the most common and destructive form of primary brain tumor. Along with surgery and radiation, chemotherapy remains as the major treatment modality. The emergence of drug resistance, however, often leads to a therapeutic failure in the treatment of glioma, precluding long-term survival of the patie...

journal_title：Current neuropharmacology

authors： Suk K

更新日期：2012-03-01 00:00:00