The Emerging Role of the Double-Edged Impact of Arachidonic Acid- Derived Eicosanoids in the Neuroinflammatory Background of Depression.

abstract：:When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clini...

journal_title：Current neuropharmacology

authors： Smith BJ,St Louis EK,Stern JM,Green C,Bramley T

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Hereditary cerebellar ataxias are a group of disorders characterized by heterogeneous clinical manifestations, progressive clinical course, and diverse genetic causes. No disease modifying treatments are yet available for many of these disorders. Oxidative stress has been recurrently identified in different ...

journal_title：Current neuropharmacology

authors： Barca E,Emmanuele V,DiMauro S,Toscano A,Quinzii CM

更新日期：2019-01-01 00:00:00

abstract：:Several lines of evidence indicate that rats emit ultrasonic vocalizations (USVs) in response to a wide range of stimuli that are capable of producing either euphoric (positive) or dysphoric (negative) emotional states. On these bases, recordings of USVs are extensively used in preclinical studies of affect, motivatio...

journal_title：Current neuropharmacology

authors： Simola N

更新日期：2015-01-01 00:00:00

abstract：:General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia, and immobility; while they may also induce side effects lik...

journal_title：Current neuropharmacology

authors： Hao X,Ou M,Zhang D,Zhao W,Yang Y,Liu J,Yang H,Zhu T,Li Y,Zhou C

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Both prescription and over-the-counter (OTC) drugs recently emerged among novel psychoactive substances (NPS) being reported as ingested for recreational purposes. Among them, benzydamine (BZY), normally prescribed as an OTC anti-inflammatory drug, is reportedly being diverted and recreationally used. OBJEC...

journal_title：Current neuropharmacology

authors： Stefania C,Andrea M,Alessio M,Mauro P,Amira G,Martin CJ,Giovanni M,Massimo DG,Fabrizio S

更新日期：2021-01-13 00:00:00

abstract：:Tissue plasminogen activator (t-PA) is the only FDA-approved drug for acute ischemic stroke treatment, but its clinical use is limited due to the narrow therapeutic time window and severe adverse effects, including hemorrhagic transformation (HT) and neurotoxicity. One of the potential resolutions is to use adjunct th...

journal_title：Current neuropharmacology

authors： Chen HS,Qi SH,Shen JG

更新日期：2017-01-01 00:00:00

abstract：:During the last decade, several meta-analytic studies employing different methodological approaches have had inconsistent conclusions regarding antidepressant efficacy. Herein, we aim to comment on methodological aspects that may have contributed to disparate findings. We initially discuss methodological inconsistenci...

journal_title：Current neuropharmacology

authors： Fountoulakis KN,McIntyre RS,Carvalho AF

更新日期：2015-01-01 00:00:00

abstract：:During the past decades Neural Stem Cells have been considered as an alternative source of cells to replace lost neurons and NSC transplantation has been indicated as a promising treatment for neurodegenerative disorders. Nevertheless, the current understanding of NSC biology suggests that, far from being mere spare p...

journal_title：Current neuropharmacology

authors： Carletti B,Piemonte F,Rossi F

更新日期：2011-06-01 00:00:00

abstract：:Animal behavioural profiles are commonly employed to investigate new therapeutic agents to treat anxiety disorders as well as to investigate the mechanism of action of anxiolytic drugs. However, many clinically important symptoms of anxiety can not be modelled directly in animals. Human models of anxiety should bridge...

journal_title：Current neuropharmacology

authors： Siepmann M,Joraschky P

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Microglia are the resident immunocompetent cells of the CNS and also constitute a unique cell type that contributes to neural network homeostasis and function. Understanding microglia cell-signaling not only will reveal their diverse functions but also will help to identify pharmacological and non-pharmacolo...

journal_title：Current neuropharmacology

authors： Pena-Ortega F

更新日期：2017-01-01 00:00:00

abstract：:The push-pull superfusion technique (PPST) is a procedure for in vivo examination of transmitter release in distinct brain areas. This technique allows to investigate dynamics of transmitter release both under normal and experimentally evoked conditions. The PPST can be modified so that it is possible to determine rel...

journal_title：Current neuropharmacology

authors： Kraus MM,Philippu A

更新日期：2015-01-01 00:00:00

abstract：:Brain research is the most expanding interdisciplinary research that is using the state of the art techniques to overcome limitations in order to conduct more accurate and effective experiments. Drug delivery to the target site in the central nervous system (CNS) is one of the most difficult steps in neuroscience rese...

journal_title：Current neuropharmacology

authors： Khanbabaie R,Jahanshahi M

更新日期：2012-12-01 00:00:00

abstract：:Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome (CFS) has been classified as a disease of the central nervous system by the WHO since 1969. Many patients carrying this diagnosis do demonstrate an almost bewildering array of biological abnormalities particularly the presence of oxidative and nitrosative stres...

journal_title：Current neuropharmacology

authors： Morris G,Maes M

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Congenital myasthenic syndromes (CMSs) are a heterogeneous group of neuromuscular disorders. Mutations of the nicotinic acetylcholine receptor epsilon subunit gene (CHRNE) are the most common causes of these disorders. CMSs are gaining increasing recognition by clinicians. However, pharmacological treatment ...

journal_title：Current neuropharmacology

authors： Huang K,Luo YB,Bi FF,Yang H

更新日期：2020-07-28 00:00:00

abstract：:Many issues remain unresolved about antipsychotic drugs. Their therapeutic potency scales with affinity for dopamine D2 receptors, but there are indications that they act indirectly, with dopamine D1 receptors (and others) as possible ultimate targets. Classical neuroleptic drugs disinhibit striatal cholinergic intern...

journal_title：Current neuropharmacology

authors： Miller R

更新日期：2009-12-01 00:00:00

abstract：:Depression is a serious psychiatric illness that affects millions of people worldwide. Weeks of antidepressant therapy are required to relieve depressive symptoms, and new drugs are still being extensively researched. The latest studies have shown that in depression, there is an imbalance between the main excitatory (...

journal_title：Current neuropharmacology

authors： Mlyniec K

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) constitutes the primary reason for mortality and morbidity in persons worldwide below 45 years of age. 1.7 million Traumatic events occur yearly in the United States alone, considering for 50,000 deaths. In severe traumatic brain injury sufferers, a considerable achievement attai...

journal_title：Current neuropharmacology

authors： Kaur P,Sharma S

更新日期：2018-01-01 00:00:00

abstract：:From the initial characterizations of inflammatory responses in Alzheimer's disease (AD) affected brains, namely the demonstration of activated microglia and reactive astrocytes, complement system activation, increased production of proinflammatory cytokines, and evidence for microglial-produced neurotoxins, there was...

journal_title：Current neuropharmacology

authors： Walker D,Lue LF

更新日期：2007-12-01 00:00:00

abstract：:Sleep, an essential physiological process, has been divided into rapid eye movement sleep (REMS) and non-REMS (NREMS) in higher animals. REMS is a unique phenomenon that unlike other sleep-waking states is not under voluntary control. Directly or indirectly it influences or gets influenced by most of the physiological...

journal_title：Current neuropharmacology

authors： Mehta R,Singh A,Bókkon I,Nath Mallick B

更新日期：2016-01-01 00:00:00

abstract：:Ion channels are complex transmembrane proteins that orchestrate the electrical signals necessary for normal function of excitable tissues, including the central nervous system, peripheral nerve, and both skeletal and cardiac muscle. Progress in molecular biology has allowed cloning and expression of genes that encode...

journal_title：Current neuropharmacology

authors： Kleopa KA

更新日期：2011-09-01 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are two distinct forms of synaptic plasticity that have been extensively characterized at the Schaffer collateral-CA1 (SCCA1) synapse and the mossy fiber (MF)-CA3 synapse within the hippocampus, and are postulated to be the molecular underpinning for several ...

journal_title：Current neuropharmacology

authors： Senter RK,Ghoshal A,Walker AG,Xiang Z,Niswender CM,Conn PJ

更新日期：2016-01-01 00:00:00

abstract：:Neurodegeneration is an initial process in the development of diabetic retinopathy (DR). High quantities of glutamate, oxidative stress, induction of the renin-angiotensin system (RAS) and elevated levels of RAGE are crucial elements in the retinal neurodegeneration caused by diabetes mellitus. At least, there is emer...

journal_title：Current neuropharmacology

authors： Iwona BS

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Over 100 people die daily from opioid overdose and $78.5B per year is spent on treatment efforts, however, the real societal cost is multifold greater. Alternative strategies to eradicate/manage drug misuse and addiction need consideration. The perception of opioid addiction as a social/criminal problem has ...

journal_title：Current neuropharmacology

authors： Abijo T,Blum K,Gondré-Lewis MC

更新日期：2020-01-01 00:00:00

abstract：:The transient receptor potential (TRP) proteins are a family of ion channels that act as cellular sensors. Several members of the TRP family are sensitive to oxidative stress mediators. Among them, TRPA1 is remarkably susceptible to various oxidants, and is known to mediate neuropathic pain and respiratory, vascular a...

journal_title：Current neuropharmacology

authors： Kozai D,Sakaguchi R,Ohwada T,Mori Y

更新日期：2015-01-01 00:00:00

abstract：:Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as m...

journal_title：Current neuropharmacology

authors： Luo J,Walters ET,Carlton SM,Hu H

更新日期：2013-12-01 00:00:00

abstract：:Malignant glioma is the most common and destructive form of primary brain tumor. Along with surgery and radiation, chemotherapy remains as the major treatment modality. The emergence of drug resistance, however, often leads to a therapeutic failure in the treatment of glioma, precluding long-term survival of the patie...

journal_title：Current neuropharmacology

authors： Suk K

更新日期：2012-03-01 00:00:00

abstract：:It has been well established that there is a connection between type II diabetes (DMTII) and Alzheimer's disease (AD). In fact, the increase in AD incidence may be an emerging complication of DMTII. Both pathologies are related to estradiol (E2) exposure on the one hand, estrogen receptors (ER) are emerging as importa...

journal_title：Current neuropharmacology

authors： Ramírez-Expósito MJ,Martínez-Martos JM,Cantón-Habas V,Carrera González MP

更新日期：2020-11-10 00:00:00

abstract：:Liver failure can lead to generalized hyperammonemia, which is thought to be the underlying cause of hepatic encephalopathy. This neuropsychiatric syndrome is accompanied by functional changes of astrocytes. These glial cells enter ammonia-induced self-amplifying cycle characterized by brain oedema, oxidative and osmo...

journal_title：Current neuropharmacology

authors： Montana V,Verkhratsky A,Parpura V

更新日期：2014-07-01 00:00:00

abstract：:In the recent years we have been observing an increased incidence of type 1 diabetes in children and adolescents. This leads to a more frequent acute complication of type 1 diabetes among children with hyperglycemia. The most common of these is diabetic ketoacidosis (DKA), while cerebral edema is the most dangerous. I...

journal_title：Current neuropharmacology

authors： Szmygel Ł,Kosiak W,Zorena K,Myśliwiec M

更新日期：2016-01-01 00:00:00

abstract：:The cannabinoids, Δ9 tetrahydrocannabinol and its analogue, nabilone, have been found to reliably attenuate the intensity and frequency of post-traumatic nightmares. This essay examines how a traumatic event is captured in the mind, after just a single exposure, and repeatedly replicated during the nights that follow....

journal_title：Current neuropharmacology

authors： Mamelak M

更新日期：2020-01-01 00:00:00