Abstract:
:During the last decade, several meta-analytic studies employing different methodological approaches have had inconsistent conclusions regarding antidepressant efficacy. Herein, we aim to comment on methodological aspects that may have contributed to disparate findings. We initially discuss methodological inconsistencies and limitations related to the conduct of individual antidepressant randomized controlled trials (RCTs), including differences in allocated samples, limitations of psychometric scales, possible explanations for the heightened placebo response rates in antidepressant RCTs across the past two decades as well as the reporting of conflicts of interest. In the second part of this article, we briefly describe the various meta-analyses techniques (e.g., simple random effects meta-analysis and network meta-analysis) and the application of these methods to synthesize evidence related to antidepressant efficacy. Recently published antidepressant metaanalyses often provide discrepant results and similar results often lead to different interpretations. Finally, we propose strategies to improve methodology considering real-world clinical scenarios.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Fountoulakis KN,McIntyre RS,Carvalho AFdoi
10.2174/1570159x13666150630174343subject
Has Abstractpub_date
2015-01-01 00:00:00pages
605-15issue
5eissn
1570-159Xissn
1875-6190pii
CN-EPUB-68412journal_volume
13pub_type
杂志文章,meta分析abstract::Metabotropic glutamate (mGlu) receptors represent the largest family of glutamate receptors in mammals and act as fine tuners of the chemical transmission in central nervous system (CNS). In the last decade, results concerning the expression and the subcellular localization of mGlu receptors further clarified their ro...
journal_title:Current neuropharmacology
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doi:10.2174/1570159X17666191127112339
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abstract:BACKGROUND:Diabetic retinopathy (DR) is an important complication of diabetes and is considered one of the main causes of blindness in moderate-income and highly-developed countries. As it is a major socioeconomic problem, defining all mechanisms that may lead to DR development is of great importance. In the 21st centu...
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doi:10.2174/1570159X18666200807144530
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journal_title:Current neuropharmacology
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doi:10.2174/1570159x14666160121115210
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abstract::The cannabinoids, Δ9 tetrahydrocannabinol and its analogue, nabilone, have been found to reliably attenuate the intensity and frequency of post-traumatic nightmares. This essay examines how a traumatic event is captured in the mind, after just a single exposure, and repeatedly replicated during the nights that follow....
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200114142321
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abstract::From the initial characterizations of inflammatory responses in Alzheimer's disease (AD) affected brains, namely the demonstration of activated microglia and reactive astrocytes, complement system activation, increased production of proinflammatory cytokines, and evidence for microglial-produced neurotoxins, there was...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907782793667
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journal_title:Current neuropharmacology
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abstract::There are several studies investigating the effects of risperidone in autism, but many of these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated the effects of risperidone on five domains of Aberrant Behaviour Checklist (ABC) scale on Autism Spectrum Disorder (ASD), as w...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2007-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2014-05-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2017-01-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2009-12-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2016-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x13666150421003225
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. METHODS:A homology model of the transmembrane and extracellular regions of an Anophele...
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更新日期:2017-11-14 00:00:00
abstract:BACKGROUND:The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucid...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160223121002
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journal_title:Current neuropharmacology
pub_type: 杂志文章
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journal_title:Current neuropharmacology
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更新日期:2021-01-13 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2011-03-01 00:00:00
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2010-09-01 00:00:00
abstract::In preclinical neuropharmacological research, molecular, cell-based, and systems using animals are well established. On the tissue level the situation is less comfortable, although during the last decades some effort went into establishing such systems, i.e. using slices of the vertebrate brain together with optical a...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Over 100 people die daily from opioid overdose and $78.5B per year is spent on treatment efforts, however, the real societal cost is multifold greater. Alternative strategies to eradicate/manage drug misuse and addiction need consideration. The perception of opioid addiction as a social/criminal problem has ...
journal_title:Current neuropharmacology
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更新日期:2020-01-01 00:00:00
abstract::Major depressive disorder (MDD) is estimated to impose maximum debilitating effects on the society by 2030, with its critical effects on health, functioning, quality of life and concomitant high levels of morbidity and mortality. Yet, the disease is inadequately understood, diagnosed and treated. Moreover, with the re...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00