Abstract:
:Alzheimer's disease is one of the most progressive forms of dementia, ultimately leading to death in aged populations. The major hallmarks of Alzheimer's disease include deposition of extracellular amyloid senile plaques and intracellular neurofibrillary tangles in brain neuronal cells. Although there are classical therapeutic options available for the treatment of the diseases, however, they provide only a symptomatic relief and do not modify the molecular pathophysiological course of the disease. Recent research advances in Alzheimer's disease have highlighted the potential role of anti-amyloid, anti-tau, and anti-inflammatory therapies. However, these therapies are still in different phases of pre-clinical/clinical development. In addition, drug repositioning/repurposing is another interesting and promising approach to explore rationalized options for the treatment of Alzheimer's disease. This review discusses the different aspects of the pathophysiological mechanism involved in the progression of Alzheimer's disease along with the limitations of current therapies. Furthermore, this review also highlights emerging investigational drugs along with recent drug repurposing approaches for Alzheimer's disease.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Singh RKdoi
10.2174/1570159X18666200128121920subject
Has Abstractpub_date
2020-01-01 00:00:00pages
868-882issue
9eissn
1570-159Xissn
1875-6190pii
CN-EPUB-103979journal_volume
18pub_type
杂志文章abstract::Tissue plasminogen activator (t-PA) is the only FDA-approved drug for acute ischemic stroke treatment, but its clinical use is limited due to the narrow therapeutic time window and severe adverse effects, including hemorrhagic transformation (HT) and neurotoxicity. One of the potential resolutions is to use adjunct th...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160620102055
更新日期:2017-01-01 00:00:00
abstract::Although originally proposed as a subtype of opioid receptors, the sigma receptor is now confirmed to be a non-opioid receptor that binds diverse classes of psychotropic drugs. Sigma receptors are subdivided into two subtypes, sigma-1 and sigma-2. The sigma-1 receptor is a 25-kDa protein possessing one putative transm...
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pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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journal_title:Current neuropharmacology
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doi:10.2174/1570159X11666131204235805
更新日期:2014-05-01 00:00:00
abstract::The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, an...
journal_title:Current neuropharmacology
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pub_type: 杂志文章,meta分析
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更新日期:2015-01-01 00:00:00
abstract::Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lo...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X16666180516095949
更新日期:2018-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2009-09-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X15666170630164226
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Currently, there is a great interest in the potential medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid system. Multiple preclinical and clinical studies l...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666190603171901
更新日期:2019-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X15666170413115754
更新日期:2017-11-14 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X13666141210224137
更新日期:2015-01-01 00:00:00
abstract::Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome (CFS) has been classified as a disease of the central nervous system by the WHO since 1969. Many patients carrying this diagnosis do demonstrate an almost bewildering array of biological abnormalities particularly the presence of oxidative and nitrosative stres...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X11666131120224653
更新日期:2014-03-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200528142429
更新日期:2020-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015911798376226
更新日期:2011-12-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X16666180412094655
更新日期:2018-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2013-09-01 00:00:00
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2007-01-01 00:00:00
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更新日期:2012-12-01 00:00:00