Abstract:
:Major depressive disorder (MDD) is estimated to impose maximum debilitating effects on the society by 2030, with its critical effects on health, functioning, quality of life and concomitant high levels of morbidity and mortality. Yet, the disease is inadequately understood, diagnosed and treated. Moreover, with the recent drastic rise in the pace of life, stress has materialized as one of the most potent environmental factors for depression. In this scenario, it is important to understand the modern pathogenetic hypotheses and mechanisms, and possibly try to shift from the traditional approaches in depression therapy. These include the elaboration of pathophysiological changes in heterogeneous systems such as genetic, epigenetic, serotonergic, noradrenergic, gammaaminobutyric acid, glutamatergic and endocannabinoid systems, neurotrophic factors, HPA axis, immune system as well as cellular stress mechanisms. These components interact with each other in a complex matrix and further elucidation of their mechanism and cascade pathways are needed. This might aid in the identification of MDD subtypes as well as the development of sophisticated biomarkers. Further, characterization might also aid in developing multitargeted therapies that hold much promise as compared to the conventional monoamine based treatment. New candidate pharmacons, refined psychotherapeutic modalities, advanced neuro-surgical and imaging techniques as well as the implementation of pharmacokinetic, pharmacogenetic prescribing guidelines constitute the emerging expanses of MDD treatment.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Athira KV,Bandopadhyay S,Samudrala PK,Naidu VGM,Lahkar M,Chakravarty Sdoi
10.2174/1570159X17666191001142934subject
Has Abstractpub_date
2020-01-01 00:00:00pages
168-187issue
3eissn
1570-159Xissn
1875-6190pii
CN-EPUB-101112journal_volume
18pub_type
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journal_title:Current neuropharmacology
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更新日期:2005-10-01 00:00:00
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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pub_type: 杂志文章,meta分析
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更新日期:2015-01-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2012-12-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2010-06-01 00:00:00
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更新日期:2020-01-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2007-03-01 00:00:00
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更新日期:2007-01-01 00:00:00
abstract::To explore the functional consequences of cannabinoid withdrawal in the rat mesolimbic dopamine system, we investigated the anatomical morphology of the mesencephalic, presumed dopaminergic, neurons and their main post-synaptic target in the Nucleus Accumbens. We found that TH-positive neurons shrink and Golgi-stained...
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更新日期:2011-03-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
abstract::The use of neuroprotective agents for stroke is pathogenetically justified, but the translation of results of preclinical studies of neuroprotectors into clinical practice has been a noticeable failure. One of the leading reasons for these failures is the one-target mechanism of their activity. p-Tyrosol (Tyr), a biop...
journal_title:Current neuropharmacology
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