Abstract:
:Glutamate receptor, ionotropic, N-methyl-D-aspartate associated protein 1 (GRINA) is a member of the NMDA receptors (NMDARs) and is involved in several neurological diseases, which governs the key processes of neuronal cell death or the release of neurotransmitters. Upregulation of GRINA has been reported in multiple diseases in human beings, such as major depressive disorder (MDD) and schizophrenia (SCZ), with which the underlying mechanisms remain elusive. In this review, we provide a general overview of the expression and physiological function of GRINA in the central nervous system (CNS) diseases, including stroke, depression ,epilepsy, SCZ, and Alzheimer's disease (AD).
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Chen K,Yang LN,Lai C,Liu D,Zhu LQdoi
10.2174/1570159X18666200303104235subject
Has Abstractpub_date
2020-01-01 00:00:00pages
861-867issue
9eissn
1570-159Xissn
1875-6190pii
CN-EPUB-104954journal_volume
18pub_type
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