Abstract:
BACKGROUND:The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucidated. METHODS:A bibliographic search in PubMed database about GPR55 actions in the CNS was made. The information was grouped for brain structures to facilitate the interpretation. Finally, we constructed a schematic representation of the current knowledge about the potential participation of GPR55 in some physiological and pathophysiological events. RESULTS:Seventy nine papers were included in the review. Only few of them showed data about GPR55 (mRNA/protein) expression in multiple brain areas. The rest showed findings in different preparations both in vitro and in vivo conditions that allowed us to speculate a potential activity of GPR55 in the different brain areas. CONCLUSION:GPR55 mRNA is expressed in several brain areas as the hippocampus, hypothalamus, frontal cortex and cerebellum; but due to the lack of information, only some speculative information about its function in these regions has been suggested. Therefore, this review provide relevant information to motivate further research about GPR55 physiology/pathophysiology in the CNS.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Marichal-Cancino BA,Fajardo-Valdez A,Ruiz-Contreras AE,Mendez-Díaz M,Prospero-García Odoi
10.2174/1570159X14666160729155441subject
Has Abstractpub_date
2017-01-01 00:00:00pages
771-778issue
5eissn
1570-159Xissn
1875-6190pii
CN-EPUB-77455journal_volume
15pub_type
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