Abstract:
:Several lines of evidence indicate that rats emit ultrasonic vocalizations (USVs) in response to a wide range of stimuli that are capable of producing either euphoric (positive) or dysphoric (negative) emotional states. On these bases, recordings of USVs are extensively used in preclinical studies of affect, motivation, and social behavior. Rat USVs are sensitive to the effects of certain classes of psychoactive drugs, suggesting that emission of rat USVs can have relevance not only to neurobiology, but also to neuropharmacology and psychopharmacology. This review summarizes three types of rat USVs, namely 40-kHz USVs emitted by pups, 22-kHz USVs and 50-kHz USVs emitted by young and adult animals, and relevance of these vocalizations to neuropharmacological studies. Attention will be focused on the issues of how rat USVs can be used to evaluate the pharmacological properties of different classes of drugs, and how rat USVs can be combined with other behavioral models used in neuropharmacology. The strengths and limitations of experimental paradigms based on the evaluation of rat USVs will also be discussed.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Simola Ndoi
10.2174/1570159x13999150318113800subject
Has Abstractpub_date
2015-01-01 00:00:00pages
164-79issue
2eissn
1570-159Xissn
1875-6190pii
CN-EPUB-66042journal_volume
13pub_type
杂志文章,评审abstract::To explore the functional consequences of cannabinoid withdrawal in the rat mesolimbic dopamine system, we investigated the anatomical morphology of the mesencephalic, presumed dopaminergic, neurons and their main post-synaptic target in the Nucleus Accumbens. We found that TH-positive neurons shrink and Golgi-stained...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015911795017083
更新日期:2011-03-01 00:00:00
abstract::Liver failure can lead to generalized hyperammonemia, which is thought to be the underlying cause of hepatic encephalopathy. This neuropsychiatric syndrome is accompanied by functional changes of astrocytes. These glial cells enter ammonia-induced self-amplifying cycle characterized by brain oedema, oxidative and osmo...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X12666140903094700
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucid...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X14666160729155441
更新日期:2017-01-01 00:00:00
abstract::Metabotropic glutamate (mGlu) receptors represent the largest family of glutamate receptors in mammals and act as fine tuners of the chemical transmission in central nervous system (CNS). In the last decade, results concerning the expression and the subcellular localization of mGlu receptors further clarified their ro...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X17666191127112339
更新日期:2020-01-01 00:00:00
abstract::Autophagy is a cellular quality control mechanism crucial for neuronal homeostasis. Defects in autophagy are critically associated with mechanisms underlying Parkinson's disease (PD), a common and debilitating neurodegenerative disorder. Autophagic dysfunction in PD can occur at several stages of the autophagy/lysosom...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x13666151030103027
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The concept of food addiction attracts much interest in the scientific community. Research is mainly based on the Yale Food Addiction Scale (YFAS), a tool developed to assess food addiction. Substance use disorder criteria have been used to develop this scale. OBJECTIVE:The aim of this paper was to review t...
journal_title:Current neuropharmacology
pub_type: 杂志文章,meta分析
doi:10.2174/1570159X16666181108093520
更新日期:2019-01-01 00:00:00
abstract::MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway,...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015911795016985
更新日期:2011-03-01 00:00:00
abstract::Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage inflicted is usually a consequence of the ability of these toxic agents to induce free radical generation within cells but especially at the level of the mitochondria. The elevated production of oxygen and nitrogen-based radical...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015910792246236
更新日期:2010-09-01 00:00:00
abstract::During the last decade, several meta-analytic studies employing different methodological approaches have had inconsistent conclusions regarding antidepressant efficacy. Herein, we aim to comment on methodological aspects that may have contributed to disparate findings. We initially discuss methodological inconsistenci...
journal_title:Current neuropharmacology
pub_type: 杂志文章,meta分析
doi:10.2174/1570159x13666150630174343
更新日期:2015-01-01 00:00:00
abstract::There are several studies investigating the effects of risperidone in autism, but many of these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated the effects of risperidone on five domains of Aberrant Behaviour Checklist (ABC) scale on Autism Spectrum Disorder (ASD), as w...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200529151741
更新日期:2020-05-29 00:00:00
abstract:BACKGROUND:Both prescription and over-the-counter (OTC) drugs recently emerged among novel psychoactive substances (NPS) being reported as ingested for recreational purposes. Among them, benzydamine (BZY), normally prescribed as an OTC anti-inflammatory drug, is reportedly being diverted and recreationally used. OBJEC...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X19666210113151136
更新日期:2021-01-13 00:00:00
abstract::The cannabinoids, Δ9 tetrahydrocannabinol and its analogue, nabilone, have been found to reliably attenuate the intensity and frequency of post-traumatic nightmares. This essay examines how a traumatic event is captured in the mind, after just a single exposure, and repeatedly replicated during the nights that follow....
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200114142321
更新日期:2020-01-01 00:00:00
abstract::Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorders. Why these aggregates form remains unclear. Equally debated is whether they are toxic, protective, or simple by-products. Increasing evidence, however, supports the notion that in general aggregates confer toxicity a...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015908784533897
更新日期:2008-06-01 00:00:00
abstract::The transient receptor potential (TRP) proteins are a family of ion channels that act as cellular sensors. Several members of the TRP family are sensitive to oxidative stress mediators. Among them, TRPA1 is remarkably susceptible to various oxidants, and is known to mediate neuropathic pain and respiratory, vascular a...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x1302150525122020
更新日期:2015-01-01 00:00:00
abstract::Brain and spinal cord injuries present significant therapeutic challenges. The treatments available for these conditions are largely ineffective, partly due to limitations in directly targeting the therapeutic agents to sites of pathology within the central nervous system (CNS). The use of stem cells to treat these co...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015910793358204
更新日期:2010-12-01 00:00:00
abstract::When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clini...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015909788848947
更新日期:2009-06-01 00:00:00
abstract::Peripheral neuropathies are a heterogeneous group of diseases affecting peripheral nerves. The causes are multiple: hereditary, metabolic, infectious, inflammatory, toxic, traumatic. The temporal profile includes acute, subacute and chronic conditions. The majority of peripheral neuropathies cause mainly muscle weakne...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015906778019536
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Currently, there is a great interest in the potential medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid system. Multiple preclinical and clinical studies l...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666190603171901
更新日期:2019-01-01 00:00:00
abstract::Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lo...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X16666180516095949
更新日期:2018-01-01 00:00:00
abstract::Temozolomide (TMZ), an oral alkylating prodrug which delivers a methyl group to purine bases of DNA (O6- guanine; N7-guanine and N3-adenine), is frequently used together with radiotherapy as part of the first-line treatment of high-grade gliomas. The main advantages are its high oral bioavailability (almost 100% altho...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200626204005
更新日期:2020-06-26 00:00:00
abstract::Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as m...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X113119990040
更新日期:2013-12-01 00:00:00
abstract::The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, an...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015913804999522
更新日期:2013-01-01 00:00:00
abstract::In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimer's disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acety...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907780866901
更新日期:2007-01-01 00:00:00
abstract::The acronym TBI refers to traumatic brain injury, an alteration of brain function, or an evidence of brain pathology, that is caused by an external force. TBI is estimated to become the third leading cause of permanent disability and mortality worldwide. TBI-related injuries can be classified in many ways, according t...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666191113100808
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a pot...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666191021111809
更新日期:2020-01-01 00:00:00
abstract::Although originally proposed as a subtype of opioid receptors, the sigma receptor is now confirmed to be a non-opioid receptor that binds diverse classes of psychotropic drugs. Sigma receptors are subdivided into two subtypes, sigma-1 and sigma-2. The sigma-1 receptor is a 25-kDa protein possessing one putative transm...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015905774322516
更新日期:2005-10-01 00:00:00
abstract::The use of neuroprotective agents for stroke is pathogenetically justified, but the translation of results of preclinical studies of neuroprotectors into clinical practice has been a noticeable failure. One of the leading reasons for these failures is the one-target mechanism of their activity. p-Tyrosol (Tyr), a biop...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200507082311
更新日期:2020-05-06 00:00:00
abstract::Many issues remain unresolved about antipsychotic drugs. Their therapeutic potency scales with affinity for dopamine D2 receptors, but there are indications that they act indirectly, with dopamine D1 receptors (and others) as possible ultimate targets. Classical neuroleptic drugs disinhibit striatal cholinergic intern...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015909790031229
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Microglia are the resident immunocompetent cells of the CNS and also constitute a unique cell type that contributes to neural network homeostasis and function. Understanding microglia cell-signaling not only will reveal their diverse functions but also will help to identify pharmacological and non-pharmacolo...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X14666160928151546
更新日期:2017-01-01 00:00:00
abstract::Animal behavioural profiles are commonly employed to investigate new therapeutic agents to treat anxiety disorders as well as to investigate the mechanism of action of anxiolytic drugs. However, many clinically important symptoms of anxiety can not be modelled directly in animals. Human models of anxiety should bridge...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907780077114
更新日期:2007-03-01 00:00:00