Abstract:
:The use of neuroprotective agents for stroke is pathogenetically justified, but the translation of results of preclinical studies of neuroprotectors into clinical practice has been a noticeable failure. One of the leading reasons for these failures is the one-target mechanism of their activity. p-Tyrosol (Tyr), a biophenol, is present in a variety of natural sources, mainly in foods, such as olive oil and wine. Tyr has a wide spectrum of biological activity: antioxidant, stress-protective, anti-inflammatory, anticancer, cardioprotective, neuroprotective and many others. This review analyzes data on the neuroprotective, antioxidant, anti-inflammatory, anti-apoptotic and other kinds of Tyr activity as well as data on the pharmacokinetics of the substance. The data presented in the review substantiate the acceptability of tyrosol as the basis for the development of a new neuroprotective drug with multitarget activity for the treatment of ischemic stroke. Tyr is a promising molecule for the development of an effective neuroprotective agent for use in ischemic stroke.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Plotnikov MB,Plotnikova TMdoi
10.2174/1570159X18666200507082311subject
Has Abstractpub_date
2020-05-06 00:00:00eissn
1570-159Xissn
1875-6190pii
CN-EPUB-106422pub_type
杂志文章abstract:BACKGROUND:Microglia are the resident immunocompetent cells of the CNS and also constitute a unique cell type that contributes to neural network homeostasis and function. Understanding microglia cell-signaling not only will reveal their diverse functions but also will help to identify pharmacological and non-pharmacolo...
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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