Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.

Abstract:

:Autophagy is a cellular quality control mechanism crucial for neuronal homeostasis. Defects in autophagy are critically associated with mechanisms underlying Parkinson's disease (PD), a common and debilitating neurodegenerative disorder. Autophagic dysfunction in PD can occur at several stages of the autophagy/lysosomal degradative machinery, contributing to the formation of intracellular protein aggregates and eventual neuronal cell death. Therefore, autophagy inducers may comprise a promising new therapeutic approach to combat neurodegeneration in PD. Several currently available FDA-approved drugs have been shown to enhance autophagy, which may allow for their repurposing for use in novel clinical conditions including PD. This review summarizes our current knowledge of deficits in the autophagy/lysosomal degradation pathways associated with PD, and highlight current approaches which target this pathway as possible means towards novel therapeutic strategies.

journal_name

Curr Neuropharmacol

authors

Rivero-Ríos P,Madero-Pérez J,Fernández B,Hilfiker S

doi

10.2174/1570159x13666151030103027

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

238-49

issue

3

eissn

1570-159X

issn

1875-6190

pii

CN-EPUB-71451

journal_volume

14

pub_type

杂志文章,评审
  • Optic Nerve and Cerebral Edema in the Course of Diabetic Ketoacidosis.

    abstract::In the recent years we have been observing an increased incidence of type 1 diabetes in children and adolescents. This leads to a more frequent acute complication of type 1 diabetes among children with hyperglycemia. The most common of these is diabetic ketoacidosis (DKA), while cerebral edema is the most dangerous. I...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159x14666160225155151

    authors: Szmygel Ł,Kosiak W,Zorena K,Myśliwiec M

    更新日期:2016-01-01 00:00:00

  • Neuroprotective Effects of Exercise Treatments After Injury: The Dual Role of Neurotrophic Factors.

    abstract:BACKGROUND:Shared connections between physical activity and neuroprotection have been studied for decades, but the mechanisms underlying this effect of specific exercise were only recently brought to light. Several evidences suggest that physical activity may be a reasonable and beneficial method to improve functional ...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X14666160330105132

    authors: Cobianchi S,Arbat-Plana A,Lopez-Alvarez VM,Navarro X

    更新日期:2017-01-01 00:00:00

  • Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors.

    abstract::Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are i...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X15666170912110450

    authors: Zoli M,Pucci S,Vilella A,Gotti C

    更新日期:2018-01-01 00:00:00

  • Recent Trends in the Management of Alzheimer's Disease: Current Therapeutic Options and Drug Repurposing Approaches.

    abstract::Alzheimer's disease is one of the most progressive forms of dementia, ultimately leading to death in aged populations. The major hallmarks of Alzheimer's disease include deposition of extracellular amyloid senile plaques and intracellular neurofibrillary tangles in brain neuronal cells. Although there are classical th...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X18666200128121920

    authors: Singh RK

    更新日期:2020-01-01 00:00:00

  • Growth Factors in the Pathogenesis of Retinal Neurodegeneration in Diabetes Mellitus.

    abstract::Neurodegeneration is an initial process in the development of diabetic retinopathy (DR). High quantities of glutamate, oxidative stress, induction of the renin-angiotensin system (RAS) and elevated levels of RAGE are crucial elements in the retinal neurodegeneration caused by diabetes mellitus. At least, there is emer...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159x14666160813182009

    authors: Iwona BS

    更新日期:2016-01-01 00:00:00

  • The TNF-alpha system: functional aspects in depression, narcolepsy and psychopharmacology.

    abstract::Changes of the tumor necrosis factor-alpha (TNF-alpha) system have been shown to be involved in the development of psychiatric disorders and are additionally associated with changes in body weight as well as endocrine and metabolic changes in psychiatric patients. TNF-alpha might, for example, contribute to the pathog...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015908785777238

    authors: Berthold-Losleben M,Himmerich H

    更新日期:2008-09-01 00:00:00

  • KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma.

    abstract:BACKGROUND:The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is widely expressed in cells of the immune system such as T- and B-lymphocytes, mast cells, macrophages and microglia, but also found in dedifferentiated vascular smooth muscle cells, fibroblasts and many cancer cells including pancreatic, prostat...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X15666170630164226

    authors: Brown BM,Pressley B,Wulff H

    更新日期:2018-01-01 00:00:00

  • Pharmacological strategy for congenital myasthenic syndrome with CHRNE mutations: a meta-analysis of case reports.

    abstract:BACKGROUND:Congenital myasthenic syndromes (CMSs) are a heterogeneous group of neuromuscular disorders. Mutations of the nicotinic acetylcholine receptor epsilon subunit gene (CHRNE) are the most common causes of these disorders. CMSs are gaining increasing recognition by clinicians. However, pharmacological treatment ...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X18666200729092332

    authors: Huang K,Luo YB,Bi FF,Yang H

    更新日期:2020-07-28 00:00:00

  • Proteomic analysis of glioma chemoresistance.

    abstract::Malignant glioma is the most common and destructive form of primary brain tumor. Along with surgery and radiation, chemotherapy remains as the major treatment modality. The emergence of drug resistance, however, often leads to a therapeutic failure in the treatment of glioma, precluding long-term survival of the patie...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015912799362733

    authors: Suk K

    更新日期:2012-03-01 00:00:00

  • Mouse Models of Familial Hemiplegic Migraine for Studying Migraine Pathophysiology.

    abstract::Migraine, an extremely disabling neurological disorder, has a strong genetic component. Since monogenic migraines (resulting from mutations or changes in a single gene) may help researchers discover migraine pathophysiology, transgenic mice models harboring gene mutations identified in Familial Hemiplegic Migraine (FH...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X17666190513085013

    authors: Dehghani A,Karatas H

    更新日期:2019-01-01 00:00:00

  • Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I.

    abstract::Bacopa monnieri, commonly known as Brahmi, has been extensively used as a neuromedicine for various disorders such as anxiety, depression and memory loss. Chemical characterization studies revealed the major active constituents of the herb as the triterpenoid saponins, bacosides. Bacoside A, the vital neuroprotective ...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X16666180419123022

    authors: Sekhar VC,Viswanathan G,Baby S

    更新日期:2019-01-01 00:00:00

  • Systematic Review of Food Addiction as Measured with the Yale Food Addiction Scale: Implications for the Food Addiction Construct.

    abstract:BACKGROUND:The concept of food addiction attracts much interest in the scientific community. Research is mainly based on the Yale Food Addiction Scale (YFAS), a tool developed to assess food addiction. Substance use disorder criteria have been used to develop this scale. OBJECTIVE:The aim of this paper was to review t...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,meta分析

    doi:10.2174/1570159X16666181108093520

    authors: Penzenstadler L,Soares C,Karila L,Khazaal Y

    更新日期:2019-01-01 00:00:00

  • Neuroretinal Apoptosis as a Vascular Dysfunction in Diabetic Patients.

    abstract:BACKGROUND:Diabetic retinopathy (DR) is an important complication of diabetes and is considered one of the main causes of blindness in moderate-income and highly-developed countries. As it is a major socioeconomic problem, defining all mechanisms that may lead to DR development is of great importance. In the 21st centu...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159x14666160523144245

    authors: Mrugacz M,Bryl A,Bossowski A

    更新日期:2016-01-01 00:00:00

  • Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine.

    abstract:BACKGROUND:Over 100 people die daily from opioid overdose and $78.5B per year is spent on treatment efforts, however, the real societal cost is multifold greater. Alternative strategies to eradicate/manage drug misuse and addiction need consideration. The perception of opioid addiction as a social/criminal problem has ...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X17666191118125702

    authors: Abijo T,Blum K,Gondré-Lewis MC

    更新日期:2020-01-01 00:00:00

  • Recent Advances in Pathophysiology of Traumatic Brain Injury.

    abstract:BACKGROUND:Traumatic brain injury (TBI) constitutes the primary reason for mortality and morbidity in persons worldwide below 45 years of age. 1.7 million Traumatic events occur yearly in the United States alone, considering for 50,000 deaths. In severe traumatic brain injury sufferers, a considerable achievement attai...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X15666170613083606

    authors: Kaur P,Sharma S

    更新日期:2018-01-01 00:00:00

  • Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part I.

    abstract::Many issues remain unresolved about antipsychotic drugs. Their therapeutic potency scales with affinity for dopamine D2 receptors, but there are indications that they act indirectly, with dopamine D1 receptors (and others) as possible ultimate targets. Classical neuroleptic drugs disinhibit striatal cholinergic intern...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015909790031229

    authors: Miller R

    更新日期:2009-12-01 00:00:00

  • Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation.

    abstract:BACKGROUND:Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a pot...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X17666191021111809

    authors: Bagdas D,Gul Z,Meade JA,Cam B,Cinkilic N,Gurun MS

    更新日期:2020-01-01 00:00:00

  • Traumatic Brain Injury: A Forensic Approach: A Literature Review.

    abstract::Traumatic brain injury (TBI) is the principal cause of invalidity and death in the population under 45 years of age worldwide. This mini-review aims to systematize the forensic approach in neuropathological studies, highlighting the proper elements to be noted during external, radiological, autoptical, and histologica...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X17666191101123145

    authors: Bertozzi G,Maglietta F,Sessa F,Scoto E,Cipolloni L,Di Mizio G,Salerno M,Pomara C

    更新日期:2020-01-01 00:00:00

  • Role of Grina/Nmdara1 in the Central Nervous System Diseases.

    abstract::Glutamate receptor, ionotropic, N-methyl-D-aspartate associated protein 1 (GRINA) is a member of the NMDA receptors (NMDARs) and is involved in several neurological diseases, which governs the key processes of neuronal cell death or the release of neurotransmitters. Upregulation of GRINA has been reported in multiple ...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X18666200303104235

    authors: Chen K,Yang LN,Lai C,Liu D,Zhu LQ

    更新日期:2020-01-01 00:00:00

  • Cannabidiol Adverse Effects and Toxicity.

    abstract:BACKGROUND:Currently, there is a great interest in the potential medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid system. Multiple preclinical and clinical studies l...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X17666190603171901

    authors: Huestis MA,Solimini R,Pichini S,Pacifici R,Carlier J,Busardò FP

    更新日期:2019-01-01 00:00:00

  • The effects of locus coeruleus and norepinephrine in methamphetamine toxicity.

    abstract::The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, an...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015913804999522

    authors: Ferrucci M,Giorgi FS,Bartalucci A,Busceti CL,Fornai F

    更新日期:2013-01-01 00:00:00

  • May exercise prevent addiction?

    abstract::Amphetamines exert their persistent addictive effects by activating brain's reward pathways, perhaps through the release of dopamine in the nucleus accumbens (and/or in other places). On the other hand, there is a relationship between dopamine and all behavioural aspects that involve motor activity and it has been dem...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015911795017380

    authors: Fontes-Ribeiro CA,Marques E,Pereira FC,Silva AP,Macedo TR

    更新日期:2011-03-01 00:00:00

  • Zinc in the Glutamatergic Theory of Depression.

    abstract::Depression is a serious psychiatric illness that affects millions of people worldwide. Weeks of antidepressant therapy are required to relieve depressive symptoms, and new drugs are still being extensively researched. The latest studies have shown that in depression, there is an imbalance between the main excitatory (...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159x13666150115220617

    authors: Mlyniec K

    更新日期:2015-01-01 00:00:00

  • Autoimmune channelopathies of the nervous system.

    abstract::Ion channels are complex transmembrane proteins that orchestrate the electrical signals necessary for normal function of excitable tissues, including the central nervous system, peripheral nerve, and both skeletal and cardiac muscle. Progress in molecular biology has allowed cloning and expression of genes that encode...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015911796557966

    authors: Kleopa KA

    更新日期:2011-09-01 00:00:00

  • Mesenchymal stem cells for treatment of CNS injury.

    abstract::Brain and spinal cord injuries present significant therapeutic challenges. The treatments available for these conditions are largely ineffective, partly due to limitations in directly targeting the therapeutic agents to sites of pathology within the central nervous system (CNS). The use of stem cells to treat these co...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015910793358204

    authors: Azari MF,Mathias L,Ozturk E,Cram DS,Boyd RL,Petratos S

    更新日期:2010-12-01 00:00:00

  • Putative Involvement of Endocrine Disruptors in the Alzheimer's disease Via the Insulin-Regulated Aminopeptidase / GLUT4 Pathway.

    abstract::It has been well established that there is a connection between type II diabetes (DMTII) and Alzheimer's disease (AD). In fact, the increase in AD incidence may be an emerging complication of DMTII. Both pathologies are related to estradiol (E2) exposure on the one hand, estrogen receptors (ER) are emerging as importa...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X18666201111103024

    authors: Ramírez-Expósito MJ,Martínez-Martos JM,Cantón-Habas V,Carrera González MP

    更新日期:2020-11-10 00:00:00

  • Use of Push-Pull Superfusion Technique for Identifying Neurotransmitters Involved in Brain Functions: Achievements and Perspectives.

    abstract::The push-pull superfusion technique (PPST) is a procedure for in vivo examination of transmitter release in distinct brain areas. This technique allows to investigate dynamics of transmitter release both under normal and experimentally evoked conditions. The PPST can be modified so that it is possible to determine rel...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159x13666150722233149

    authors: Kraus MM,Philippu A

    更新日期:2015-01-01 00:00:00

  • Nightmares and the Cannabinoids.

    abstract::The cannabinoids, Δ9 tetrahydrocannabinol and its analogue, nabilone, have been found to reliably attenuate the intensity and frequency of post-traumatic nightmares. This essay examines how a traumatic event is captured in the mind, after just a single exposure, and repeatedly replicated during the nights that follow....

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X18666200114142321

    authors: Mamelak M

    更新日期:2020-01-01 00:00:00

  • Allosteric modulation of the calcium-sensing receptor.

    abstract::The calcium (Ca(2+))-sensing receptor (CaR) belongs to family C of the G-protein coupled receptors (GPCRs). The receptor is activated by physiological levels of Ca(2+) (and Mg(2+)) and positively modulated by a range of proteinogenic L-alpha-amino acids. Recently, several synthetic allosteric modulators of the recepto...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015907781695982

    authors: Jensen AA,Bräuner-Osborne H

    更新日期:2007-09-01 00:00:00

  • Relevance of excitable media theory and retinal spreading depression experiments in preclinical pharmacological research.

    abstract::In preclinical neuropharmacological research, molecular, cell-based, and systems using animals are well established. On the tissue level the situation is less comfortable, although during the last decades some effort went into establishing such systems, i.e. using slices of the vertebrate brain together with optical a...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X12666140630190800

    authors: V M Fde L,W H

    更新日期:2014-09-01 00:00:00