Abstract:
:Autophagy is a cellular quality control mechanism crucial for neuronal homeostasis. Defects in autophagy are critically associated with mechanisms underlying Parkinson's disease (PD), a common and debilitating neurodegenerative disorder. Autophagic dysfunction in PD can occur at several stages of the autophagy/lysosomal degradative machinery, contributing to the formation of intracellular protein aggregates and eventual neuronal cell death. Therefore, autophagy inducers may comprise a promising new therapeutic approach to combat neurodegeneration in PD. Several currently available FDA-approved drugs have been shown to enhance autophagy, which may allow for their repurposing for use in novel clinical conditions including PD. This review summarizes our current knowledge of deficits in the autophagy/lysosomal degradation pathways associated with PD, and highlight current approaches which target this pathway as possible means towards novel therapeutic strategies.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Rivero-Ríos P,Madero-Pérez J,Fernández B,Hilfiker Sdoi
10.2174/1570159x13666151030103027subject
Has Abstractpub_date
2016-01-01 00:00:00pages
238-49issue
3eissn
1570-159Xissn
1875-6190pii
CN-EPUB-71451journal_volume
14pub_type
杂志文章,评审abstract:BACKGROUND:Currently, there is a great interest in the potential medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid system. Multiple preclinical and clinical studies l...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666190603171901
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Both prescription and over-the-counter (OTC) drugs recently emerged among novel psychoactive substances (NPS) being reported as ingested for recreational purposes. Among them, benzydamine (BZY), normally prescribed as an OTC anti-inflammatory drug, is reportedly being diverted and recreationally used. OBJEC...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X19666210113151136
更新日期:2021-01-13 00:00:00
abstract::To explore the functional consequences of cannabinoid withdrawal in the rat mesolimbic dopamine system, we investigated the anatomical morphology of the mesencephalic, presumed dopaminergic, neurons and their main post-synaptic target in the Nucleus Accumbens. We found that TH-positive neurons shrink and Golgi-stained...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015911795017083
更新日期:2011-03-01 00:00:00
abstract::From the initial characterizations of inflammatory responses in Alzheimer's disease (AD) affected brains, namely the demonstration of activated microglia and reactive astrocytes, complement system activation, increased production of proinflammatory cytokines, and evidence for microglial-produced neurotoxins, there was...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907782793667
更新日期:2007-12-01 00:00:00
abstract::New psychoactive substances (NPS) have completely modified the drug scene and the current landscape of addiction. Synthetic substances, such as substituted or synthetic cathinones, also known as « legal highs », are often produced and used to mimic the effects of controlled drugs such as cocaine, methylenedioxymethamp...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X13666141210224137
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Over 100 people die daily from opioid overdose and $78.5B per year is spent on treatment efforts, however, the real societal cost is multifold greater. Alternative strategies to eradicate/manage drug misuse and addiction need consideration. The perception of opioid addiction as a social/criminal problem has ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X17666191118125702
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is widely expressed in cells of the immune system such as T- and B-lymphocytes, mast cells, macrophages and microglia, but also found in dedifferentiated vascular smooth muscle cells, fibroblasts and many cancer cells including pancreatic, prostat...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X15666170630164226
更新日期:2018-01-01 00:00:00
abstract::Alzheimer's disease, Parkinson's disease, traumatic brain and spinal cord injury and neuroinflammatory multiple sclerosis are diverse disorders of the central nervous system. However, they are all characterized by various levels of inappropriate inflammatory/immune response along with tissue destruction. In the gastro...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160121115210
更新日期:2016-01-01 00:00:00
abstract::Drug addiction results from the interplay between social and biological factors. Among these, genetic variables play a major role. The use of genetically related inbred rat strains that differ in their preference for drugs of abuse is one approach of great importance to explore genetic determinants. Lewis and Fischer ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015911795017290
更新日期:2011-03-01 00:00:00
abstract::Brain research is the most expanding interdisciplinary research that is using the state of the art techniques to overcome limitations in order to conduct more accurate and effective experiments. Drug delivery to the target site in the central nervous system (CNS) is one of the most difficult steps in neuroscience rese...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015912804143513
更新日期:2012-12-01 00:00:00
abstract::Major depressive disorder (MDD) is estimated to impose maximum debilitating effects on the society by 2030, with its critical effects on health, functioning, quality of life and concomitant high levels of morbidity and mortality. Yet, the disease is inadequately understood, diagnosed and treated. Moreover, with the re...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666191001142934
更新日期:2020-01-01 00:00:00
abstract::Sleep, an essential physiological process, has been divided into rapid eye movement sleep (REMS) and non-REMS (NREMS) in higher animals. REMS is a unique phenomenon that unlike other sleep-waking states is not under voluntary control. Directly or indirectly it influences or gets influenced by most of the physiological...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x13666150414185737
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucid...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X14666160729155441
更新日期:2017-01-01 00:00:00
abstract::Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage inflicted is usually a consequence of the ability of these toxic agents to induce free radical generation within cells but especially at the level of the mitochondria. The elevated production of oxygen and nitrogen-based radical...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015910792246236
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Congenital myasthenic syndromes (CMSs) are a heterogeneous group of neuromuscular disorders. Mutations of the nicotinic acetylcholine receptor epsilon subunit gene (CHRNE) are the most common causes of these disorders. CMSs are gaining increasing recognition by clinicians. However, pharmacological treatment ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200729092332
更新日期:2020-07-28 00:00:00
abstract::Although originally proposed as a subtype of opioid receptors, the sigma receptor is now confirmed to be a non-opioid receptor that binds diverse classes of psychotropic drugs. Sigma receptors are subdivided into two subtypes, sigma-1 and sigma-2. The sigma-1 receptor is a 25-kDa protein possessing one putative transm...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015905774322516
更新日期:2005-10-01 00:00:00
abstract::Alzheimer's disease is one of the most progressive forms of dementia, ultimately leading to death in aged populations. The major hallmarks of Alzheimer's disease include deposition of extracellular amyloid senile plaques and intracellular neurofibrillary tangles in brain neuronal cells. Although there are classical th...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200128121920
更新日期:2020-01-01 00:00:00
abstract::Parkinson's disease (PD) is a common progressive, neurodegenerative brain disease that is promoted by mitochondrial dysfunction, oxidative stress, protein aggregation and proteasome dysfunction in the brain. Compared with computer tomography (CT) or magnetic resonance imaging (MRI), non-invasive nuclear radiopharmaceu...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X13666141204221238
更新日期:2014-12-01 00:00:00
abstract::In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimer's disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acety...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907780866901
更新日期:2007-01-01 00:00:00
abstract::General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia, and immobility; while they may also induce side effects lik...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200227125854
更新日期:2020-01-01 00:00:00
abstract::Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lo...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X16666180516095949
更新日期:2018-01-01 00:00:00
abstract::Migraine, an extremely disabling neurological disorder, has a strong genetic component. Since monogenic migraines (resulting from mutations or changes in a single gene) may help researchers discover migraine pathophysiology, transgenic mice models harboring gene mutations identified in Familial Hemiplegic Migraine (FH...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666190513085013
更新日期:2019-01-01 00:00:00
abstract::When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clini...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015909788848947
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Diabetic retinopathy (DR) is an important complication of diabetes and is considered one of the main causes of blindness in moderate-income and highly-developed countries. As it is a major socioeconomic problem, defining all mechanisms that may lead to DR development is of great importance. In the 21st centu...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160523144245
更新日期:2016-01-01 00:00:00
abstract::Malignant glioma is the most common and destructive form of primary brain tumor. Along with surgery and radiation, chemotherapy remains as the major treatment modality. The emergence of drug resistance, however, often leads to a therapeutic failure in the treatment of glioma, precluding long-term survival of the patie...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015912799362733
更新日期:2012-03-01 00:00:00
abstract::Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are i...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X15666170912110450
更新日期:2018-01-01 00:00:00
abstract::There are several studies investigating the effects of risperidone in autism, but many of these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated the effects of risperidone on five domains of Aberrant Behaviour Checklist (ABC) scale on Autism Spectrum Disorder (ASD), as w...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200529151741
更新日期:2020-05-29 00:00:00
abstract::The use of neuroprotective agents for stroke is pathogenetically justified, but the translation of results of preclinical studies of neuroprotectors into clinical practice has been a noticeable failure. One of the leading reasons for these failures is the one-target mechanism of their activity. p-Tyrosol (Tyr), a biop...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200507082311
更新日期:2020-05-06 00:00:00
abstract::Traumatic brain injury (TBI) is the principal cause of invalidity and death in the population under 45 years of age worldwide. This mini-review aims to systematize the forensic approach in neuropathological studies, highlighting the proper elements to be noted during external, radiological, autoptical, and histologica...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X17666191101123145
更新日期:2020-01-01 00:00:00
abstract::Peripheral neuropathies are a heterogeneous group of diseases affecting peripheral nerves. The causes are multiple: hereditary, metabolic, infectious, inflammatory, toxic, traumatic. The temporal profile includes acute, subacute and chronic conditions. The majority of peripheral neuropathies cause mainly muscle weakne...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015906778019536
更新日期:2006-07-01 00:00:00