Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.

abstract：:Migraine, an extremely disabling neurological disorder, has a strong genetic component. Since monogenic migraines (resulting from mutations or changes in a single gene) may help researchers discover migraine pathophysiology, transgenic mice models harboring gene mutations identified in Familial Hemiplegic Migraine (FH...

journal_title：Current neuropharmacology

authors： Dehghani A,Karatas H

更新日期：2019-01-01 00:00:00

abstract：:Metabotropic glutamate (mGlu) receptors represent the largest family of glutamate receptors in mammals and act as fine tuners of the chemical transmission in central nervous system (CNS). In the last decade, results concerning the expression and the subcellular localization of mGlu receptors further clarified their ro...

journal_title：Current neuropharmacology

authors： Olivero G,Vergassola M,Cisani F,Roggeri A,Pittaluga A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Depression is among the commonest of psychiatric disorders, and inflammatory mechanisms have been suggested to play a role in its pathophysiology. Interferons are a superfamily of proinflammatory cytokines that play a role in host defence mechanisms. Interferons are used in the treatment of a variety of auto...

journal_title：Current neuropharmacology

authors： Pinto EF,Andrade C

更新日期：2016-01-01 00:00:00

abstract：:Bacopa monnieri, commonly known as Brahmi, has been extensively used as a neuromedicine for various disorders such as anxiety, depression and memory loss. Chemical characterization studies revealed the major active constituents of the herb as the triterpenoid saponins, bacosides. Bacoside A, the vital neuroprotective ...

journal_title：Current neuropharmacology

authors： Sekhar VC,Viswanathan G,Baby S

更新日期：2019-01-01 00:00:00

abstract：:The 'omnipresence' of adenosine in all nervous system cells (neurons and glia) together with the intensive release of adenosine following insults, makes adenosine as a sort of 'maestro' of synapses leading to the homeostatic coordination of brain function. Besides direct actions of adenosine on the neurosecretory mech...

journal_title：Current neuropharmacology

authors： Sebastião AM,Ribeiro JA

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Microglia are the resident immunocompetent cells of the CNS and also constitute a unique cell type that contributes to neural network homeostasis and function. Understanding microglia cell-signaling not only will reveal their diverse functions but also will help to identify pharmacological and non-pharmacolo...

journal_title：Current neuropharmacology

authors： Pena-Ortega F

更新日期：2017-01-01 00:00:00

abstract：:Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage inflicted is usually a consequence of the ability of these toxic agents to induce free radical generation within cells but especially at the level of the mitochondria. The elevated production of oxygen and nitrogen-based radical...

journal_title：Current neuropharmacology

authors： Reiter RJ,Manchester LC,Tan DX

更新日期：2010-09-01 00:00:00

abstract：:Several lines of evidence indicate that rats emit ultrasonic vocalizations (USVs) in response to a wide range of stimuli that are capable of producing either euphoric (positive) or dysphoric (negative) emotional states. On these bases, recordings of USVs are extensively used in preclinical studies of affect, motivatio...

journal_title：Current neuropharmacology

authors： Simola N

更新日期：2015-01-01 00:00:00

abstract：:It has been well established that there is a connection between type II diabetes (DMTII) and Alzheimer's disease (AD). In fact, the increase in AD incidence may be an emerging complication of DMTII. Both pathologies are related to estradiol (E2) exposure on the one hand, estrogen receptors (ER) are emerging as importa...

journal_title：Current neuropharmacology

authors： Ramírez-Expósito MJ,Martínez-Martos JM,Cantón-Habas V,Carrera González MP

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. METHODS:A homology model of the transmembrane and extracellular regions of an Anophele...

journal_title：Current neuropharmacology

authors： Vinekar RS,Sowdhamini R

更新日期：2017-11-14 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are two distinct forms of synaptic plasticity that have been extensively characterized at the Schaffer collateral-CA1 (SCCA1) synapse and the mossy fiber (MF)-CA3 synapse within the hippocampus, and are postulated to be the molecular underpinning for several ...

journal_title：Current neuropharmacology

authors： Senter RK,Ghoshal A,Walker AG,Xiang Z,Niswender CM,Conn PJ

更新日期：2016-01-01 00:00:00

abstract：:In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimer's disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acety...

journal_title：Current neuropharmacology

authors： Chen S,Zhang XJ,Li L,Le WD

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Over 100 people die daily from opioid overdose and $78.5B per year is spent on treatment efforts, however, the real societal cost is multifold greater. Alternative strategies to eradicate/manage drug misuse and addiction need consideration. The perception of opioid addiction as a social/criminal problem has ...

journal_title：Current neuropharmacology

authors： Abijo T,Blum K,Gondré-Lewis MC

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The concept of food addiction attracts much interest in the scientific community. Research is mainly based on the Yale Food Addiction Scale (YFAS), a tool developed to assess food addiction. Substance use disorder criteria have been used to develop this scale. OBJECTIVE:The aim of this paper was to review t...

journal_title：Current neuropharmacology

authors： Penzenstadler L,Soares C,Karila L,Khazaal Y

更新日期：2019-01-01 00:00:00

abstract：:The use of neuroprotective agents for stroke is pathogenetically justified, but the translation of results of preclinical studies of neuroprotectors into clinical practice has been a noticeable failure. One of the leading reasons for these failures is the one-target mechanism of their activity. p-Tyrosol (Tyr), a biop...

journal_title：Current neuropharmacology

authors： Plotnikov MB,Plotnikova TM

更新日期：2020-05-06 00:00:00

abstract：:The calcium (Ca(2+))-sensing receptor (CaR) belongs to family C of the G-protein coupled receptors (GPCRs). The receptor is activated by physiological levels of Ca(2+) (and Mg(2+)) and positively modulated by a range of proteinogenic L-alpha-amino acids. Recently, several synthetic allosteric modulators of the recepto...

journal_title：Current neuropharmacology

authors： Jensen AA,Bräuner-Osborne H

更新日期：2007-09-01 00:00:00

abstract：:The push-pull superfusion technique (PPST) is a procedure for in vivo examination of transmitter release in distinct brain areas. This technique allows to investigate dynamics of transmitter release both under normal and experimentally evoked conditions. The PPST can be modified so that it is possible to determine rel...

journal_title：Current neuropharmacology

authors： Kraus MM,Philippu A

更新日期：2015-01-01 00:00:00

abstract：:There are several studies investigating the effects of risperidone in autism, but many of these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated the effects of risperidone on five domains of Aberrant Behaviour Checklist (ABC) scale on Autism Spectrum Disorder (ASD), as w...

journal_title：Current neuropharmacology

authors： Mano-Sousa BJ,Pedrosa AM,Alves BC,Galduróz JCF,Belo VS,Chaves VE,Duarte-Almeida JM

更新日期：2020-05-29 00:00:00

abstract：:During the past decades Neural Stem Cells have been considered as an alternative source of cells to replace lost neurons and NSC transplantation has been indicated as a promising treatment for neurodegenerative disorders. Nevertheless, the current understanding of NSC biology suggests that, far from being mere spare p...

journal_title：Current neuropharmacology

authors： Carletti B,Piemonte F,Rossi F

更新日期：2011-06-01 00:00:00

abstract：:Temozolomide (TMZ), an oral alkylating prodrug which delivers a methyl group to purine bases of DNA (O6- guanine; N7-guanine and N3-adenine), is frequently used together with radiotherapy as part of the first-line treatment of high-grade gliomas. The main advantages are its high oral bioavailability (almost 100% altho...

journal_title：Current neuropharmacology

authors： Ortiz R,Perazzoli G,Cabeza L,Jiménez-Luna C,Luque R,Prados J,Melguizo C

更新日期：2020-06-26 00:00:00

abstract：:Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorders. Why these aggregates form remains unclear. Equally debated is whether they are toxic, protective, or simple by-products. Increasing evidence, however, supports the notion that in general aggregates confer toxicity a...

journal_title：Current neuropharmacology

authors： Bossy B,Perkins G,Bossy-Wetzel E

更新日期：2008-06-01 00:00:00

abstract：:In preclinical neuropharmacological research, molecular, cell-based, and systems using animals are well established. On the tissue level the situation is less comfortable, although during the last decades some effort went into establishing such systems, i.e. using slices of the vertebrate brain together with optical a...

journal_title：Current neuropharmacology

authors： V M Fde L,W H

更新日期：2014-09-01 00:00:00

abstract：:Liver failure can lead to generalized hyperammonemia, which is thought to be the underlying cause of hepatic encephalopathy. This neuropsychiatric syndrome is accompanied by functional changes of astrocytes. These glial cells enter ammonia-induced self-amplifying cycle characterized by brain oedema, oxidative and osmo...

journal_title：Current neuropharmacology

authors： Montana V,Verkhratsky A,Parpura V

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a pot...

journal_title：Current neuropharmacology

authors： Bagdas D,Gul Z,Meade JA,Cam B,Cinkilic N,Gurun MS

更新日期：2020-01-01 00:00:00

abstract：:Amphetamines exert their persistent addictive effects by activating brain's reward pathways, perhaps through the release of dopamine in the nucleus accumbens (and/or in other places). On the other hand, there is a relationship between dopamine and all behavioural aspects that involve motor activity and it has been dem...

journal_title：Current neuropharmacology

authors： Fontes-Ribeiro CA,Marques E,Pereira FC,Silva AP,Macedo TR

更新日期：2011-03-01 00:00:00

abstract：:Eicosanoids are arachidonic acid (AA) derivatives belonging to a family of lipid signalling mediators that are engaged in both physiological and pathological processes in the brain. Recently, their implication in the prolonged inflammatory response has become a focus of particular interest because, in contrast to acut...

journal_title：Current neuropharmacology

authors： Regulska M,Szuster-Głuszczak M,Trojan E,Leśkiewicz M,Basta-Kaim A

更新日期：2021-01-01 00:00:00

abstract：:Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lo...

journal_title：Current neuropharmacology

authors： Li D,Ni H,Rui Q,Gao R,Chen G

更新日期：2018-01-01 00:00:00

abstract：:Pediatric Bipolar Disorder (BD) is a highly morbid pediatric psychiatric disease, consistently associated with family psychiatric history of mood disorders and associated with high levels of morbidity and disability and with a great risk of suicide. While there is a general consensus on the symptomatology of depressio...

journal_title：Current neuropharmacology

authors： Serra G,Uchida M,Battaglia C,Casini MP,De Chiara L,Biederman J,Vicari S,Wozniak J

更新日期：2017-04-01 00:00:00

abstract：:Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as m...

journal_title：Current neuropharmacology

authors： Luo J,Walters ET,Carlton SM,Hu H

更新日期：2013-12-01 00:00:00

abstract：:Changes of the tumor necrosis factor-alpha (TNF-alpha) system have been shown to be involved in the development of psychiatric disorders and are additionally associated with changes in body weight as well as endocrine and metabolic changes in psychiatric patients. TNF-alpha might, for example, contribute to the pathog...

journal_title：Current neuropharmacology

authors： Berthold-Losleben M,Himmerich H

更新日期：2008-09-01 00:00:00