Abstract:
BACKGROUND:Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks. OBJECTIVE:This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed. MATERIALS AND METHODS:An electronic literature search was conducted by authors up to October 2019. Original articles were selected. RESULTS:CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models. CONCLUSION:The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Bagdas D,Gul Z,Meade JA,Cam B,Cinkilic N,Gurun MSdoi
10.2174/1570159X17666191021111809subject
Has Abstractpub_date
2020-01-01 00:00:00pages
216-228issue
3eissn
1570-159Xissn
1875-6190pii
CN-EPUB-101699journal_volume
18pub_type
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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abstract::The acronym TBI refers to traumatic brain injury, an alteration of brain function, or an evidence of brain pathology, that is caused by an external force. TBI is estimated to become the third leading cause of permanent disability and mortality worldwide. TBI-related injuries can be classified in many ways, according t...
journal_title:Current neuropharmacology
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