Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain.

abstract：:Bacopa monnieri, commonly known as Brahmi, has been extensively used as a neuromedicine for various disorders such as anxiety, depression and memory loss. Chemical characterization studies revealed the major active constituents of the herb as the triterpenoid saponins, bacosides. Bacoside A, the vital neuroprotective ...

journal_title：Current neuropharmacology

authors： Sekhar VC,Viswanathan G,Baby S

更新日期：2019-01-01 00:00:00

abstract：:The heat shock protein (Hsp) family is an evolutionarily conserved system that is charged with preventing unfolded or misfolded proteins in the cell from aggregating. In Alzheimer's disease, extracellular accumulation of the amyloid β peptide (Aβ) and intracellular aggregation of the microtubule associated protein tau...

journal_title：Current neuropharmacology

authors： Abisambra JF,Jinwal UK,Jones JR,Blair LJ,Koren J 3rd,Dickey CA

更新日期：2011-12-01 00:00:00

abstract：:Migraine, an extremely disabling neurological disorder, has a strong genetic component. Since monogenic migraines (resulting from mutations or changes in a single gene) may help researchers discover migraine pathophysiology, transgenic mice models harboring gene mutations identified in Familial Hemiplegic Migraine (FH...

journal_title：Current neuropharmacology

authors： Dehghani A,Karatas H

更新日期：2019-01-01 00:00:00

abstract：:Temozolomide (TMZ), an oral alkylating prodrug which delivers a methyl group to purine bases of DNA (O6- guanine; N7-guanine and N3-adenine), is frequently used together with radiotherapy as part of the first-line treatment of high-grade gliomas. The main advantages are its high oral bioavailability (almost 100% altho...

journal_title：Current neuropharmacology

authors： Ortiz R,Perazzoli G,Cabeza L,Jiménez-Luna C,Luque R,Prados J,Melguizo C

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucid...

journal_title：Current neuropharmacology

authors： Marichal-Cancino BA,Fajardo-Valdez A,Ruiz-Contreras AE,Mendez-Díaz M,Prospero-García O

更新日期：2017-01-01 00:00:00

abstract：:Autophagy is a cellular quality control mechanism crucial for neuronal homeostasis. Defects in autophagy are critically associated with mechanisms underlying Parkinson's disease (PD), a common and debilitating neurodegenerative disorder. Autophagic dysfunction in PD can occur at several stages of the autophagy/lysosom...

journal_title：Current neuropharmacology

authors： Rivero-Ríos P,Madero-Pérez J,Fernández B,Hilfiker S

更新日期：2016-01-01 00:00:00

abstract：:Several lines of evidence indicate that rats emit ultrasonic vocalizations (USVs) in response to a wide range of stimuli that are capable of producing either euphoric (positive) or dysphoric (negative) emotional states. On these bases, recordings of USVs are extensively used in preclinical studies of affect, motivatio...

journal_title：Current neuropharmacology

authors： Simola N

更新日期：2015-01-01 00:00:00

abstract：:Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often life-threatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR)...

journal_title：Current neuropharmacology

authors： González-Maeso J,Meana JJ

更新日期：2006-04-01 00:00:00

abstract：:The calcium (Ca(2+))-sensing receptor (CaR) belongs to family C of the G-protein coupled receptors (GPCRs). The receptor is activated by physiological levels of Ca(2+) (and Mg(2+)) and positively modulated by a range of proteinogenic L-alpha-amino acids. Recently, several synthetic allosteric modulators of the recepto...

journal_title：Current neuropharmacology

authors： Jensen AA,Bräuner-Osborne H

更新日期：2007-09-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are i...

journal_title：Current neuropharmacology

authors： Zoli M,Pucci S,Vilella A,Gotti C

更新日期：2018-01-01 00:00:00

abstract：:When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clini...

journal_title：Current neuropharmacology

authors： Smith BJ,St Louis EK,Stern JM,Green C,Bramley T

更新日期：2009-06-01 00:00:00

abstract：:Metabotropic glutamate (mGlu) receptors represent the largest family of glutamate receptors in mammals and act as fine tuners of the chemical transmission in central nervous system (CNS). In the last decade, results concerning the expression and the subcellular localization of mGlu receptors further clarified their ro...

journal_title：Current neuropharmacology

authors： Olivero G,Vergassola M,Cisani F,Roggeri A,Pittaluga A

更新日期：2020-01-01 00:00:00

abstract：:Brain research is the most expanding interdisciplinary research that is using the state of the art techniques to overcome limitations in order to conduct more accurate and effective experiments. Drug delivery to the target site in the central nervous system (CNS) is one of the most difficult steps in neuroscience rese...

journal_title：Current neuropharmacology

authors： Khanbabaie R,Jahanshahi M

更新日期：2012-12-01 00:00:00

abstract：:Neurodegeneration is an initial process in the development of diabetic retinopathy (DR). High quantities of glutamate, oxidative stress, induction of the renin-angiotensin system (RAS) and elevated levels of RAGE are crucial elements in the retinal neurodegeneration caused by diabetes mellitus. At least, there is emer...

journal_title：Current neuropharmacology

authors： Iwona BS

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Both prescription and over-the-counter (OTC) drugs recently emerged among novel psychoactive substances (NPS) being reported as ingested for recreational purposes. Among them, benzydamine (BZY), normally prescribed as an OTC anti-inflammatory drug, is reportedly being diverted and recreationally used. OBJEC...

journal_title：Current neuropharmacology

authors： Stefania C,Andrea M,Alessio M,Mauro P,Amira G,Martin CJ,Giovanni M,Massimo DG,Fabrizio S

更新日期：2021-01-13 00:00:00

abstract：:During the last decade, several meta-analytic studies employing different methodological approaches have had inconsistent conclusions regarding antidepressant efficacy. Herein, we aim to comment on methodological aspects that may have contributed to disparate findings. We initially discuss methodological inconsistenci...

journal_title：Current neuropharmacology

authors： Fountoulakis KN,McIntyre RS,Carvalho AF

更新日期：2015-01-01 00:00:00

abstract：:Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome (CFS) has been classified as a disease of the central nervous system by the WHO since 1969. Many patients carrying this diagnosis do demonstrate an almost bewildering array of biological abnormalities particularly the presence of oxidative and nitrosative stres...

journal_title：Current neuropharmacology

authors： Morris G,Maes M

更新日期：2014-03-01 00:00:00

abstract：:Sleep, an essential physiological process, has been divided into rapid eye movement sleep (REMS) and non-REMS (NREMS) in higher animals. REMS is a unique phenomenon that unlike other sleep-waking states is not under voluntary control. Directly or indirectly it influences or gets influenced by most of the physiological...

journal_title：Current neuropharmacology

authors： Mehta R,Singh A,Bókkon I,Nath Mallick B

更新日期：2016-01-01 00:00:00

abstract：:In the recent years we have been observing an increased incidence of type 1 diabetes in children and adolescents. This leads to a more frequent acute complication of type 1 diabetes among children with hyperglycemia. The most common of these is diabetic ketoacidosis (DKA), while cerebral edema is the most dangerous. I...

journal_title：Current neuropharmacology

authors： Szmygel Ł,Kosiak W,Zorena K,Myśliwiec M

更新日期：2016-01-01 00:00:00

abstract：:Brain and spinal cord injuries present significant therapeutic challenges. The treatments available for these conditions are largely ineffective, partly due to limitations in directly targeting the therapeutic agents to sites of pathology within the central nervous system (CNS). The use of stem cells to treat these co...

journal_title：Current neuropharmacology

authors： Azari MF,Mathias L,Ozturk E,Cram DS,Boyd RL,Petratos S

更新日期：2010-12-01 00:00:00

abstract：:Alzheimer's disease, Parkinson's disease, traumatic brain and spinal cord injury and neuroinflammatory multiple sclerosis are diverse disorders of the central nervous system. However, they are all characterized by various levels of inappropriate inflammatory/immune response along with tissue destruction. In the gastro...

journal_title：Current neuropharmacology

authors： Földes A,Kádár K,Kerémi B,Zsembery Á,Gyires K,S Zádori Z,Varga G

更新日期：2016-01-01 00:00:00

abstract：:Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage inflicted is usually a consequence of the ability of these toxic agents to induce free radical generation within cells but especially at the level of the mitochondria. The elevated production of oxygen and nitrogen-based radical...

journal_title：Current neuropharmacology

authors： Reiter RJ,Manchester LC,Tan DX

更新日期：2010-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) is the principal cause of invalidity and death in the population under 45 years of age worldwide. This mini-review aims to systematize the forensic approach in neuropathological studies, highlighting the proper elements to be noted during external, radiological, autoptical, and histologica...

journal_title：Current neuropharmacology

authors： Bertozzi G,Maglietta F,Sessa F,Scoto E,Cipolloni L,Di Mizio G,Salerno M,Pomara C

更新日期：2020-01-01 00:00:00

abstract：:Diffuse intrinsic pontine gliomas (DIPGs) are invariably fatal tumors found in the pons of elementary school aged children. These tumors are grade II-IV gliomas, with a median survival of less than 1 year from diagnosis when treated with standard of care (SOC) therapy. Nanotechnology may offer therapeutic options for ...

journal_title：Current neuropharmacology

authors： Bredlau AL,Dixit S,Chen C,Broome AM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The only conclusive way to diagnose Alzheimer's is to carry out brain autopsy of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other form of dementia. However, due to the non-feasibility of such methods, to diagnose and conclude the conditions, medical practitioners use ...

journal_title：Current neuropharmacology

authors： Khan S,Barve KH,Kumar MS

更新日期：2020-01-01 00:00:00

abstract：:Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorders. Why these aggregates form remains unclear. Equally debated is whether they are toxic, protective, or simple by-products. Increasing evidence, however, supports the notion that in general aggregates confer toxicity a...

journal_title：Current neuropharmacology

authors： Bossy B,Perkins G,Bossy-Wetzel E

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Congenital myasthenic syndromes (CMSs) are a heterogeneous group of neuromuscular disorders. Mutations of the nicotinic acetylcholine receptor epsilon subunit gene (CHRNE) are the most common causes of these disorders. CMSs are gaining increasing recognition by clinicians. However, pharmacological treatment ...

journal_title：Current neuropharmacology

authors： Huang K,Luo YB,Bi FF,Yang H

更新日期：2020-07-28 00:00:00

abstract：:The acronym TBI refers to traumatic brain injury, an alteration of brain function, or an evidence of brain pathology, that is caused by an external force. TBI is estimated to become the third leading cause of permanent disability and mortality worldwide. TBI-related injuries can be classified in many ways, according t...

journal_title：Current neuropharmacology

authors： Pinchi E,Frati P,Arcangeli M,Volonnino G,Tomassi R,Santoro P,Cipolloni L

更新日期：2020-01-01 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are two distinct forms of synaptic plasticity that have been extensively characterized at the Schaffer collateral-CA1 (SCCA1) synapse and the mossy fiber (MF)-CA3 synapse within the hippocampus, and are postulated to be the molecular underpinning for several ...

journal_title：Current neuropharmacology

authors： Senter RK,Ghoshal A,Walker AG,Xiang Z,Niswender CM,Conn PJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is widely expressed in cells of the immune system such as T- and B-lymphocytes, mast cells, macrophages and microglia, but also found in dedifferentiated vascular smooth muscle cells, fibroblasts and many cancer cells including pancreatic, prostat...

journal_title：Current neuropharmacology

authors： Brown BM,Pressley B,Wulff H

更新日期：2018-01-01 00:00:00