Pharmacological strategy for congenital myasthenic syndrome with CHRNE mutations: a meta-analysis of case reports.

abstract：:Changes of the tumor necrosis factor-alpha (TNF-alpha) system have been shown to be involved in the development of psychiatric disorders and are additionally associated with changes in body weight as well as endocrine and metabolic changes in psychiatric patients. TNF-alpha might, for example, contribute to the pathog...

journal_title：Current neuropharmacology

authors： Berthold-Losleben M,Himmerich H

更新日期：2008-09-01 00:00:00

abstract：:The cannabinoids, Δ9 tetrahydrocannabinol and its analogue, nabilone, have been found to reliably attenuate the intensity and frequency of post-traumatic nightmares. This essay examines how a traumatic event is captured in the mind, after just a single exposure, and repeatedly replicated during the nights that follow....

journal_title：Current neuropharmacology

authors： Mamelak M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Currently, there is a great interest in the potential medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid system. Multiple preclinical and clinical studies l...

journal_title：Current neuropharmacology

authors： Huestis MA,Solimini R,Pichini S,Pacifici R,Carlier J,Busardò FP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Microglia are the resident immunocompetent cells of the CNS and also constitute a unique cell type that contributes to neural network homeostasis and function. Understanding microglia cell-signaling not only will reveal their diverse functions but also will help to identify pharmacological and non-pharmacolo...

journal_title：Current neuropharmacology

authors： Pena-Ortega F

更新日期：2017-01-01 00:00:00

abstract：:The use of neuroprotective agents for stroke is pathogenetically justified, but the translation of results of preclinical studies of neuroprotectors into clinical practice has been a noticeable failure. One of the leading reasons for these failures is the one-target mechanism of their activity. p-Tyrosol (Tyr), a biop...

journal_title：Current neuropharmacology

authors： Plotnikov MB,Plotnikova TM

更新日期：2020-05-06 00:00:00

abstract：:General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia, and immobility; while they may also induce side effects lik...

journal_title：Current neuropharmacology

authors： Hao X,Ou M,Zhang D,Zhao W,Yang Y,Liu J,Yang H,Zhu T,Li Y,Zhou C

更新日期：2020-01-01 00:00:00

abstract：:Ketamine is a noncompetitive antagonist of the NMDA-receptors, used as a dissociative anesthetic, presently included in the category of the psychoactive substances known as "club drugs". Ketamine administration was associated with impaired working memory and increased psychopathological symptoms, but there is a lack o...

journal_title：Current neuropharmacology

authors： Venâncio C,Magalhães A,Antunes L,Summavielle T

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a pot...

journal_title：Current neuropharmacology

authors： Bagdas D,Gul Z,Meade JA,Cam B,Cinkilic N,Gurun MS

更新日期：2020-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is the principal cause of invalidity and death in the population under 45 years of age worldwide. This mini-review aims to systematize the forensic approach in neuropathological studies, highlighting the proper elements to be noted during external, radiological, autoptical, and histologica...

journal_title：Current neuropharmacology

authors： Bertozzi G,Maglietta F,Sessa F,Scoto E,Cipolloni L,Di Mizio G,Salerno M,Pomara C

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. METHODS:A homology model of the transmembrane and extracellular regions of an Anophele...

journal_title：Current neuropharmacology

authors： Vinekar RS,Sowdhamini R

更新日期：2017-11-14 00:00:00

abstract：:Ion channels are complex transmembrane proteins that orchestrate the electrical signals necessary for normal function of excitable tissues, including the central nervous system, peripheral nerve, and both skeletal and cardiac muscle. Progress in molecular biology has allowed cloning and expression of genes that encode...

journal_title：Current neuropharmacology

authors： Kleopa KA

更新日期：2011-09-01 00:00:00

abstract：:Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins: the Aquaporins (AQPs). These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in ...

journal_title：Current neuropharmacology

authors： Buffoli B

更新日期：2010-06-01 00:00:00

abstract：:Alzheimer's disease is one of the most progressive forms of dementia, ultimately leading to death in aged populations. The major hallmarks of Alzheimer's disease include deposition of extracellular amyloid senile plaques and intracellular neurofibrillary tangles in brain neuronal cells. Although there are classical th...

journal_title：Current neuropharmacology

authors： Singh RK

更新日期：2020-01-01 00:00:00

abstract：:The 'omnipresence' of adenosine in all nervous system cells (neurons and glia) together with the intensive release of adenosine following insults, makes adenosine as a sort of 'maestro' of synapses leading to the homeostatic coordination of brain function. Besides direct actions of adenosine on the neurosecretory mech...

journal_title：Current neuropharmacology

authors： Sebastião AM,Ribeiro JA

更新日期：2009-09-01 00:00:00

abstract：:Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal dorsal horn and this output informs the brain as to the peripheral en...

journal_title：Current neuropharmacology

authors： Yaksh TL,Fisher CJ,Hockman TM,Wiese AJ

更新日期：2017-01-01 00:00:00

abstract：:Amphetamines exert their persistent addictive effects by activating brain's reward pathways, perhaps through the release of dopamine in the nucleus accumbens (and/or in other places). On the other hand, there is a relationship between dopamine and all behavioural aspects that involve motor activity and it has been dem...

journal_title：Current neuropharmacology

authors： Fontes-Ribeiro CA,Marques E,Pereira FC,Silva AP,Macedo TR

更新日期：2011-03-01 00:00:00

abstract：:Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lo...

journal_title：Current neuropharmacology

authors： Li D,Ni H,Rui Q,Gao R,Chen G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The concept of food addiction attracts much interest in the scientific community. Research is mainly based on the Yale Food Addiction Scale (YFAS), a tool developed to assess food addiction. Substance use disorder criteria have been used to develop this scale. OBJECTIVE:The aim of this paper was to review t...

journal_title：Current neuropharmacology

authors： Penzenstadler L,Soares C,Karila L,Khazaal Y

更新日期：2019-01-01 00:00:00

abstract：:Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often life-threatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR)...

journal_title：Current neuropharmacology

authors： González-Maeso J,Meana JJ

更新日期：2006-04-01 00:00:00

abstract：:Brain research is the most expanding interdisciplinary research that is using the state of the art techniques to overcome limitations in order to conduct more accurate and effective experiments. Drug delivery to the target site in the central nervous system (CNS) is one of the most difficult steps in neuroscience rese...

journal_title：Current neuropharmacology

authors： Khanbabaie R,Jahanshahi M

更新日期：2012-12-01 00:00:00

abstract：:In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimer's disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acety...

journal_title：Current neuropharmacology

authors： Chen S,Zhang XJ,Li L,Le WD

更新日期：2007-01-01 00:00:00

abstract：:MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway,...

journal_title：Current neuropharmacology

authors： Takamatsu Y,Shiotsuki H,Kasai S,Sato S,Iwamura T,Hattori N,Ikeda K

更新日期：2011-03-01 00:00:00

abstract：:Metabotropic glutamate (mGlu) receptors represent the largest family of glutamate receptors in mammals and act as fine tuners of the chemical transmission in central nervous system (CNS). In the last decade, results concerning the expression and the subcellular localization of mGlu receptors further clarified their ro...

journal_title：Current neuropharmacology

authors： Olivero G,Vergassola M,Cisani F,Roggeri A,Pittaluga A

更新日期：2020-01-01 00:00:00

abstract：:There are several studies investigating the effects of risperidone in autism, but many of these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated the effects of risperidone on five domains of Aberrant Behaviour Checklist (ABC) scale on Autism Spectrum Disorder (ASD), as w...

journal_title：Current neuropharmacology

authors： Mano-Sousa BJ,Pedrosa AM,Alves BC,Galduróz JCF,Belo VS,Chaves VE,Duarte-Almeida JM

更新日期：2020-05-29 00:00:00

abstract：:Animal behavioural profiles are commonly employed to investigate new therapeutic agents to treat anxiety disorders as well as to investigate the mechanism of action of anxiolytic drugs. However, many clinically important symptoms of anxiety can not be modelled directly in animals. Human models of anxiety should bridge...

journal_title：Current neuropharmacology

authors： Siepmann M,Joraschky P

更新日期：2007-03-01 00:00:00

abstract：:As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery o...

journal_title：Current neuropharmacology

authors： Murray AP,Faraoni MB,Castro MJ,Alza NP,Cavallaro V

更新日期：2013-07-01 00:00:00

abstract：:Pediatric Bipolar Disorder (BD) is a highly morbid pediatric psychiatric disease, consistently associated with family psychiatric history of mood disorders and associated with high levels of morbidity and disability and with a great risk of suicide. While there is a general consensus on the symptomatology of depressio...

journal_title：Current neuropharmacology

authors： Serra G,Uchida M,Battaglia C,Casini MP,De Chiara L,Biederman J,Vicari S,Wozniak J

更新日期：2017-04-01 00:00:00

abstract：:Bacopa monnieri, commonly known as Brahmi, has been extensively used as a neuromedicine for various disorders such as anxiety, depression and memory loss. Chemical characterization studies revealed the major active constituents of the herb as the triterpenoid saponins, bacosides. Bacoside A, the vital neuroprotective ...

journal_title：Current neuropharmacology

authors： Sekhar VC,Viswanathan G,Baby S

更新日期：2019-01-01 00:00:00

abstract：:Several lines of evidence indicate that rats emit ultrasonic vocalizations (USVs) in response to a wide range of stimuli that are capable of producing either euphoric (positive) or dysphoric (negative) emotional states. On these bases, recordings of USVs are extensively used in preclinical studies of affect, motivatio...

journal_title：Current neuropharmacology

authors： Simola N

更新日期：2015-01-01 00:00:00

abstract：:In the recent years we have been observing an increased incidence of type 1 diabetes in children and adolescents. This leads to a more frequent acute complication of type 1 diabetes among children with hyperglycemia. The most common of these is diabetic ketoacidosis (DKA), while cerebral edema is the most dangerous. I...

journal_title：Current neuropharmacology

authors： Szmygel Ł,Kosiak W,Zorena K,Myśliwiec M

更新日期：2016-01-01 00:00:00