Abstract:
:In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimer's disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acetylcholinesterase treatment to multiple mechanisms-based therapy targeting amyloid plaques formation and amyloid peptides (Abeta)-mediated cytotoxicity, and neurofibrillary tangles generation. This review will cover current experimental studies with the focus on secretases-based drug development, immunotherapy, and anti-neurofibrillary tangles intervention. The outcome of these on-going studies may provide high hope that AD can be cured in the future.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Chen S,Zhang XJ,Li L,Le WDdoi
10.2174/157015907780866901subject
Has Abstractpub_date
2007-01-01 00:00:00pages
127-34issue
2eissn
1570-159Xissn
1875-6190journal_volume
5pub_type
杂志文章abstract:BACKGROUND:Diabetic retinopathy (DR) is an important complication of diabetes and is considered one of the main causes of blindness in moderate-income and highly-developed countries. As it is a major socioeconomic problem, defining all mechanisms that may lead to DR development is of great importance. In the 21st centu...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2007-03-01 00:00:00
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