Abstract:
:When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clinician's perspective of patient concerns. Findings of a literature review of articles that report patient-expressed concerns regarding their epilepsy and treatment were also reviewed. Results showed that the specialist panel appropriately identified patient-reported concerns of driving ability, medication cost, seizure control, and medication side effects. Additionally, patient-reported concerns of independence, employment issues, social stigma, medication dependence, and undesirable cognitive effects are important to address when considering and initiating AED conversion.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Smith BJ,St Louis EK,Stern JM,Green C,Bramley Tdoi
10.2174/157015909788848947subject
Has Abstractpub_date
2009-06-01 00:00:00pages
120-4issue
2eissn
1570-159Xissn
1875-6190journal_volume
7pub_type
杂志文章abstract:BACKGROUND:Congenital myasthenic syndromes (CMSs) are a heterogeneous group of neuromuscular disorders. Mutations of the nicotinic acetylcholine receptor epsilon subunit gene (CHRNE) are the most common causes of these disorders. CMSs are gaining increasing recognition by clinicians. However, pharmacological treatment ...
journal_title:Current neuropharmacology
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abstract::MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway,...
journal_title:Current neuropharmacology
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abstract::In preclinical neuropharmacological research, molecular, cell-based, and systems using animals are well established. On the tissue level the situation is less comfortable, although during the last decades some effort went into establishing such systems, i.e. using slices of the vertebrate brain together with optical a...
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更新日期:2014-09-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::Liver failure can lead to generalized hyperammonemia, which is thought to be the underlying cause of hepatic encephalopathy. This neuropsychiatric syndrome is accompanied by functional changes of astrocytes. These glial cells enter ammonia-induced self-amplifying cycle characterized by brain oedema, oxidative and osmo...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2013-09-01 00:00:00
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2016-01-01 00:00:00
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更新日期:2005-10-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Diabetic retinopathy (DR) is an important complication of diabetes and is considered one of the main causes of blindness in moderate-income and highly-developed countries. As it is a major socioeconomic problem, defining all mechanisms that may lead to DR development is of great importance. In the 21st centu...
journal_title:Current neuropharmacology
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更新日期:2016-01-01 00:00:00
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2015-01-01 00:00:00
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更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:The concept of food addiction attracts much interest in the scientific community. Research is mainly based on the Yale Food Addiction Scale (YFAS), a tool developed to assess food addiction. Substance use disorder criteria have been used to develop this scale. OBJECTIVE:The aim of this paper was to review t...
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更新日期:2019-01-01 00:00:00
abstract::Ketamine is a noncompetitive antagonist of the NMDA-receptors, used as a dissociative anesthetic, presently included in the category of the psychoactive substances known as "club drugs". Ketamine administration was associated with impaired working memory and increased psychopathological symptoms, but there is a lack o...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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abstract::Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are i...
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abstract::Several lines of evidence indicate that rats emit ultrasonic vocalizations (USVs) in response to a wide range of stimuli that are capable of producing either euphoric (positive) or dysphoric (negative) emotional states. On these bases, recordings of USVs are extensively used in preclinical studies of affect, motivatio...
journal_title:Current neuropharmacology
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abstract::The 'omnipresence' of adenosine in all nervous system cells (neurons and glia) together with the intensive release of adenosine following insults, makes adenosine as a sort of 'maestro' of synapses leading to the homeostatic coordination of brain function. Besides direct actions of adenosine on the neurosecretory mech...
journal_title:Current neuropharmacology
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更新日期:2009-09-01 00:00:00
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更新日期:2018-01-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2017-01-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2008-06-01 00:00:00