The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies.

abstract：BACKGROUND:Depression is among the commonest of psychiatric disorders, and inflammatory mechanisms have been suggested to play a role in its pathophysiology. Interferons are a superfamily of proinflammatory cytokines that play a role in host defence mechanisms. Interferons are used in the treatment of a variety of auto...

journal_title：Current neuropharmacology

authors： Pinto EF,Andrade C

更新日期：2016-01-01 00:00:00

abstract：:Eicosanoids are arachidonic acid (AA) derivatives belonging to a family of lipid signalling mediators that are engaged in both physiological and pathological processes in the brain. Recently, their implication in the prolonged inflammatory response has become a focus of particular interest because, in contrast to acut...

journal_title：Current neuropharmacology

authors： Regulska M,Szuster-Głuszczak M,Trojan E,Leśkiewicz M,Basta-Kaim A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Hereditary cerebellar ataxias are a group of disorders characterized by heterogeneous clinical manifestations, progressive clinical course, and diverse genetic causes. No disease modifying treatments are yet available for many of these disorders. Oxidative stress has been recurrently identified in different ...

journal_title：Current neuropharmacology

authors： Barca E,Emmanuele V,DiMauro S,Toscano A,Quinzii CM

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) constitutes the primary reason for mortality and morbidity in persons worldwide below 45 years of age. 1.7 million Traumatic events occur yearly in the United States alone, considering for 50,000 deaths. In severe traumatic brain injury sufferers, a considerable achievement attai...

journal_title：Current neuropharmacology

authors： Kaur P,Sharma S

更新日期：2018-01-01 00:00:00

abstract：:Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome (CFS) has been classified as a disease of the central nervous system by the WHO since 1969. Many patients carrying this diagnosis do demonstrate an almost bewildering array of biological abnormalities particularly the presence of oxidative and nitrosative stres...

journal_title：Current neuropharmacology

authors： Morris G,Maes M

更新日期：2014-03-01 00:00:00

abstract：:During the last decade, several meta-analytic studies employing different methodological approaches have had inconsistent conclusions regarding antidepressant efficacy. Herein, we aim to comment on methodological aspects that may have contributed to disparate findings. We initially discuss methodological inconsistenci...

journal_title：Current neuropharmacology

authors： Fountoulakis KN,McIntyre RS,Carvalho AF

更新日期：2015-01-01 00:00:00

abstract：:The cannabinoids, Δ9 tetrahydrocannabinol and its analogue, nabilone, have been found to reliably attenuate the intensity and frequency of post-traumatic nightmares. This essay examines how a traumatic event is captured in the mind, after just a single exposure, and repeatedly replicated during the nights that follow....

journal_title：Current neuropharmacology

authors： Mamelak M

更新日期：2020-01-01 00:00:00

abstract：:Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lo...

journal_title：Current neuropharmacology

authors： Li D,Ni H,Rui Q,Gao R,Chen G

更新日期：2018-01-01 00:00:00

abstract：:In the recent years we have been observing an increased incidence of type 1 diabetes in children and adolescents. This leads to a more frequent acute complication of type 1 diabetes among children with hyperglycemia. The most common of these is diabetic ketoacidosis (DKA), while cerebral edema is the most dangerous. I...

journal_title：Current neuropharmacology

authors： Szmygel Ł,Kosiak W,Zorena K,Myśliwiec M

更新日期：2016-01-01 00:00:00

abstract：:General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia, and immobility; while they may also induce side effects lik...

journal_title：Current neuropharmacology

authors： Hao X,Ou M,Zhang D,Zhao W,Yang Y,Liu J,Yang H,Zhu T,Li Y,Zhou C

更新日期：2020-01-01 00:00:00

abstract：:The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought to serve as a key relay connecting limbic forebrain structures to hypothalamic and brainstem reg...

journal_title：Current neuropharmacology

authors： Crestani CC,Alves FH,Gomes FV,Resstel LB,Correa FM,Herman JP

更新日期：2013-03-01 00:00:00

abstract：:Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage inflicted is usually a consequence of the ability of these toxic agents to induce free radical generation within cells but especially at the level of the mitochondria. The elevated production of oxygen and nitrogen-based radical...

journal_title：Current neuropharmacology

authors： Reiter RJ,Manchester LC,Tan DX

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Currently, there is a great interest in the potential medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid system. Multiple preclinical and clinical studies l...

journal_title：Current neuropharmacology

authors： Huestis MA,Solimini R,Pichini S,Pacifici R,Carlier J,Busardò FP

更新日期：2019-01-01 00:00:00

abstract：:Tissue plasminogen activator (t-PA) is the only FDA-approved drug for acute ischemic stroke treatment, but its clinical use is limited due to the narrow therapeutic time window and severe adverse effects, including hemorrhagic transformation (HT) and neurotoxicity. One of the potential resolutions is to use adjunct th...

journal_title：Current neuropharmacology

authors： Chen HS,Qi SH,Shen JG

更新日期：2017-01-01 00:00:00

abstract：:Brain and spinal cord injuries present significant therapeutic challenges. The treatments available for these conditions are largely ineffective, partly due to limitations in directly targeting the therapeutic agents to sites of pathology within the central nervous system (CNS). The use of stem cells to treat these co...

journal_title：Current neuropharmacology

authors： Azari MF,Mathias L,Ozturk E,Cram DS,Boyd RL,Petratos S

更新日期：2010-12-01 00:00:00

abstract：:Ketamine is a noncompetitive antagonist of the NMDA-receptors, used as a dissociative anesthetic, presently included in the category of the psychoactive substances known as "club drugs". Ketamine administration was associated with impaired working memory and increased psychopathological symptoms, but there is a lack o...

journal_title：Current neuropharmacology

authors： Venâncio C,Magalhães A,Antunes L,Summavielle T

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Diabetic retinopathy (DR) is an important complication of diabetes and is considered one of the main causes of blindness in moderate-income and highly-developed countries. As it is a major socioeconomic problem, defining all mechanisms that may lead to DR development is of great importance. In the 21st centu...

journal_title：Current neuropharmacology

authors： Mrugacz M,Bryl A,Bossowski A

更新日期：2016-01-01 00:00:00

abstract：:Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often life-threatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR)...

journal_title：Current neuropharmacology

authors： González-Maeso J,Meana JJ

更新日期：2006-04-01 00:00:00

abstract：:The acronym TBI refers to traumatic brain injury, an alteration of brain function, or an evidence of brain pathology, that is caused by an external force. TBI is estimated to become the third leading cause of permanent disability and mortality worldwide. TBI-related injuries can be classified in many ways, according t...

journal_title：Current neuropharmacology

authors： Pinchi E,Frati P,Arcangeli M,Volonnino G,Tomassi R,Santoro P,Cipolloni L

更新日期：2020-01-01 00:00:00

abstract：:Pediatric Bipolar Disorder (BD) is a highly morbid pediatric psychiatric disease, consistently associated with family psychiatric history of mood disorders and associated with high levels of morbidity and disability and with a great risk of suicide. While there is a general consensus on the symptomatology of depressio...

journal_title：Current neuropharmacology

authors： Serra G,Uchida M,Battaglia C,Casini MP,De Chiara L,Biederman J,Vicari S,Wozniak J

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Both prescription and over-the-counter (OTC) drugs recently emerged among novel psychoactive substances (NPS) being reported as ingested for recreational purposes. Among them, benzydamine (BZY), normally prescribed as an OTC anti-inflammatory drug, is reportedly being diverted and recreationally used. OBJEC...

journal_title：Current neuropharmacology

authors： Stefania C,Andrea M,Alessio M,Mauro P,Amira G,Martin CJ,Giovanni M,Massimo DG,Fabrizio S

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucid...

journal_title：Current neuropharmacology

authors： Marichal-Cancino BA,Fajardo-Valdez A,Ruiz-Contreras AE,Mendez-Díaz M,Prospero-García O

更新日期：2017-01-01 00:00:00

abstract：:Migraine, an extremely disabling neurological disorder, has a strong genetic component. Since monogenic migraines (resulting from mutations or changes in a single gene) may help researchers discover migraine pathophysiology, transgenic mice models harboring gene mutations identified in Familial Hemiplegic Migraine (FH...

journal_title：Current neuropharmacology

authors： Dehghani A,Karatas H

更新日期：2019-01-01 00:00:00

abstract：:Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorders. Why these aggregates form remains unclear. Equally debated is whether they are toxic, protective, or simple by-products. Increasing evidence, however, supports the notion that in general aggregates confer toxicity a...

journal_title：Current neuropharmacology

authors： Bossy B,Perkins G,Bossy-Wetzel E

更新日期：2008-06-01 00:00:00

abstract：:Alzheimer's disease is one of the most progressive forms of dementia, ultimately leading to death in aged populations. The major hallmarks of Alzheimer's disease include deposition of extracellular amyloid senile plaques and intracellular neurofibrillary tangles in brain neuronal cells. Although there are classical th...

journal_title：Current neuropharmacology

authors： Singh RK

更新日期：2020-01-01 00:00:00

abstract：:It has been well established that there is a connection between type II diabetes (DMTII) and Alzheimer's disease (AD). In fact, the increase in AD incidence may be an emerging complication of DMTII. Both pathologies are related to estradiol (E2) exposure on the one hand, estrogen receptors (ER) are emerging as importa...

journal_title：Current neuropharmacology

authors： Ramírez-Expósito MJ,Martínez-Martos JM,Cantón-Habas V,Carrera González MP

更新日期：2020-11-10 00:00:00

abstract：:From the initial characterizations of inflammatory responses in Alzheimer's disease (AD) affected brains, namely the demonstration of activated microglia and reactive astrocytes, complement system activation, increased production of proinflammatory cytokines, and evidence for microglial-produced neurotoxins, there was...

journal_title：Current neuropharmacology

authors： Walker D,Lue LF

更新日期：2007-12-01 00:00:00

abstract：:Peripheral neuropathies are a heterogeneous group of diseases affecting peripheral nerves. The causes are multiple: hereditary, metabolic, infectious, inflammatory, toxic, traumatic. The temporal profile includes acute, subacute and chronic conditions. The majority of peripheral neuropathies cause mainly muscle weakne...

journal_title：Current neuropharmacology

authors： Marchettini P,Lacerenza M,Mauri E,Marangoni C

更新日期：2006-07-01 00:00:00

abstract：:Parkinson's disease (PD) is a common progressive, neurodegenerative brain disease that is promoted by mitochondrial dysfunction, oxidative stress, protein aggregation and proteasome dysfunction in the brain. Compared with computer tomography (CT) or magnetic resonance imaging (MRI), non-invasive nuclear radiopharmaceu...

journal_title：Current neuropharmacology

authors： Wu X,Cai H,Ge R,Li L,Jia Z

更新日期：2014-12-01 00:00:00

abstract：:Brain research is the most expanding interdisciplinary research that is using the state of the art techniques to overcome limitations in order to conduct more accurate and effective experiments. Drug delivery to the target site in the central nervous system (CNS) is one of the most difficult steps in neuroscience rese...

journal_title：Current neuropharmacology

authors： Khanbabaie R,Jahanshahi M

更新日期：2012-12-01 00:00:00