Abstract:
:Malignant glioma is the most common and destructive form of primary brain tumor. Along with surgery and radiation, chemotherapy remains as the major treatment modality. The emergence of drug resistance, however, often leads to a therapeutic failure in the treatment of glioma, precluding long-term survival of the patients. A proteomic approach has recently been adapted for the mechanistic analysis of glioma drug resistance. The proteomic analysis of drug-resistant glioma led to the discovery of novel biomarkers that can be used for the prognosis of glioma as well as for monitoring the drug response or resistance of glioma. These proteomics-based biomarkers can also be a druggable target that one can exploit for successful glioma chemotherapy. In this review, recent reports on proteomic analysis of glioma from the perspective of chemoresistance are discussed with a focus on the proteome profiles of glioma cells that are resistant to the alkylating agent, 1, 3-bis (2-chloroethyl)-1-nitrosourea (BCNU), as a prime example. Among numerous proteins that were up- or down-regulated in drug-resistant glioma cells, lipocalin 2 (LCN2) and integrin β3 (ITGB3) were identified as key proteins that determine the survival and death of glioma cells. LCN2, ITGB3, and other proteins identified by proteomic analysis could be utilized to overcome glioma chemoresistance.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Suk Kdoi
10.2174/157015912799362733subject
Has Abstractpub_date
2012-03-01 00:00:00pages
72-9issue
1eissn
1570-159Xissn
1875-6190pii
CN-10-72journal_volume
10pub_type
杂志文章abstract::Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal dorsal horn and this output informs the brain as to the peripheral en...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160307145542
更新日期:2017-01-01 00:00:00
abstract::Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome (CFS) has been classified as a disease of the central nervous system by the WHO since 1969. Many patients carrying this diagnosis do demonstrate an almost bewildering array of biological abnormalities particularly the presence of oxidative and nitrosative stres...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X11666131120224653
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. METHODS:A homology model of the transmembrane and extracellular regions of an Anophele...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1567201814666161205131213
更新日期:2017-11-14 00:00:00
abstract::Alzheimer's disease, Parkinson's disease, traumatic brain and spinal cord injury and neuroinflammatory multiple sclerosis are diverse disorders of the central nervous system. However, they are all characterized by various levels of inappropriate inflammatory/immune response along with tissue destruction. In the gastro...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160121115210
更新日期:2016-01-01 00:00:00
abstract::Major depressive disorder (MDD) is estimated to impose maximum debilitating effects on the society by 2030, with its critical effects on health, functioning, quality of life and concomitant high levels of morbidity and mortality. Yet, the disease is inadequately understood, diagnosed and treated. Moreover, with the re...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666191001142934
更新日期:2020-01-01 00:00:00
abstract::Several lines of evidence indicate that rats emit ultrasonic vocalizations (USVs) in response to a wide range of stimuli that are capable of producing either euphoric (positive) or dysphoric (negative) emotional states. On these bases, recordings of USVs are extensively used in preclinical studies of affect, motivatio...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x13999150318113800
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The only conclusive way to diagnose Alzheimer's is to carry out brain autopsy of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other form of dementia. However, due to the non-feasibility of such methods, to diagnose and conclude the conditions, medical practitioners use ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200528142429
更新日期:2020-01-01 00:00:00
abstract::MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway,...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015911795016985
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Both prescription and over-the-counter (OTC) drugs recently emerged among novel psychoactive substances (NPS) being reported as ingested for recreational purposes. Among them, benzydamine (BZY), normally prescribed as an OTC anti-inflammatory drug, is reportedly being diverted and recreationally used. OBJEC...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X19666210113151136
更新日期:2021-01-13 00:00:00
abstract:BACKGROUND:The concept of food addiction attracts much interest in the scientific community. Research is mainly based on the Yale Food Addiction Scale (YFAS), a tool developed to assess food addiction. Substance use disorder criteria have been used to develop this scale. OBJECTIVE:The aim of this paper was to review t...
journal_title:Current neuropharmacology
pub_type: 杂志文章,meta分析
doi:10.2174/1570159X16666181108093520
更新日期:2019-01-01 00:00:00
abstract::The calcium (Ca(2+))-sensing receptor (CaR) belongs to family C of the G-protein coupled receptors (GPCRs). The receptor is activated by physiological levels of Ca(2+) (and Mg(2+)) and positively modulated by a range of proteinogenic L-alpha-amino acids. Recently, several synthetic allosteric modulators of the recepto...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907781695982
更新日期:2007-09-01 00:00:00
abstract::Many issues remain unresolved about antipsychotic drugs. Their therapeutic potency scales with affinity for dopamine D2 receptors, but there are indications that they act indirectly, with dopamine D1 receptors (and others) as possible ultimate targets. Classical neuroleptic drugs disinhibit striatal cholinergic intern...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015909790031229
更新日期:2009-12-01 00:00:00
abstract::As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery o...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X11311040004
更新日期:2013-07-01 00:00:00
abstract::From the initial characterizations of inflammatory responses in Alzheimer's disease (AD) affected brains, namely the demonstration of activated microglia and reactive astrocytes, complement system activation, increased production of proinflammatory cytokines, and evidence for microglial-produced neurotoxins, there was...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907782793667
更新日期:2007-12-01 00:00:00
abstract::Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often life-threatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR)...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015906776359586
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:The treatment of schizophrenia is challenging due to the wide range of symptoms (positive, negative, cognitive) associated with the disease. Typical antipsychotics that antagonize D2 receptors are effective in treating positive symptoms, but extrapyramidal side-effects (EPS) are a common occurrence. Atypical...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X15666170413115754
更新日期:2017-11-14 00:00:00
abstract::The use of neuroprotective agents for stroke is pathogenetically justified, but the translation of results of preclinical studies of neuroprotectors into clinical practice has been a noticeable failure. One of the leading reasons for these failures is the one-target mechanism of their activity. p-Tyrosol (Tyr), a biop...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200507082311
更新日期:2020-05-06 00:00:00
abstract::It is well recognized the role of the Wnt pathway in many developmental processes such as neuronal maturation, migration, neuronal connectivity and synaptic formation. Growing evidence is also demonstrating its function in the mature brain where is associated with modulation of axonal remodeling, dendrite outgrowth, s...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X11311050001
更新日期:2013-09-01 00:00:00
abstract::Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lo...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X16666180516095949
更新日期:2018-01-01 00:00:00
abstract::The cannabinoids, Δ9 tetrahydrocannabinol and its analogue, nabilone, have been found to reliably attenuate the intensity and frequency of post-traumatic nightmares. This essay examines how a traumatic event is captured in the mind, after just a single exposure, and repeatedly replicated during the nights that follow....
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200114142321
更新日期:2020-01-01 00:00:00
abstract::The push-pull superfusion technique (PPST) is a procedure for in vivo examination of transmitter release in distinct brain areas. This technique allows to investigate dynamics of transmitter release both under normal and experimentally evoked conditions. The PPST can be modified so that it is possible to determine rel...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x13666150722233149
更新日期:2015-01-01 00:00:00
abstract::Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are i...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X15666170912110450
更新日期:2018-01-01 00:00:00
abstract::Tumor necrosis factor receptor-associated factor (TRAF) is an important binding protein of tumor necrosis factor (TNF) superfamily and the toll/IL-1 receptor (TIR) superfamily, which play an important role in innate immunity and acquired immunity. TRAFs family have 7 members (TRAF1-7), and TRAF6 has its special factur...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X16666180412094655
更新日期:2018-01-01 00:00:00
abstract::Long-term potentiation (LTP) and long-term depression (LTD) are two distinct forms of synaptic plasticity that have been extensively characterized at the Schaffer collateral-CA1 (SCCA1) synapse and the mossy fiber (MF)-CA3 synapse within the hippocampus, and are postulated to be the molecular underpinning for several ...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x13666150421003225
更新日期:2016-01-01 00:00:00
abstract::Neurodegeneration is an initial process in the development of diabetic retinopathy (DR). High quantities of glutamate, oxidative stress, induction of the renin-angiotensin system (RAS) and elevated levels of RAGE are crucial elements in the retinal neurodegeneration caused by diabetes mellitus. At least, there is emer...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160813182009
更新日期:2016-01-01 00:00:00
abstract::In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimer's disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acety...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907780866901
更新日期:2007-01-01 00:00:00
abstract::The 'omnipresence' of adenosine in all nervous system cells (neurons and glia) together with the intensive release of adenosine following insults, makes adenosine as a sort of 'maestro' of synapses leading to the homeostatic coordination of brain function. Besides direct actions of adenosine on the neurosecretory mech...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015909789152128
更新日期:2009-09-01 00:00:00
abstract::It has been well established that there is a connection between type II diabetes (DMTII) and Alzheimer's disease (AD). In fact, the increase in AD incidence may be an emerging complication of DMTII. Both pathologies are related to estradiol (E2) exposure on the one hand, estrogen receptors (ER) are emerging as importa...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666201111103024
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucid...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X14666160729155441
更新日期:2017-01-01 00:00:00
abstract::Parkinson's disease (PD) is a common progressive, neurodegenerative brain disease that is promoted by mitochondrial dysfunction, oxidative stress, protein aggregation and proteasome dysfunction in the brain. Compared with computer tomography (CT) or magnetic resonance imaging (MRI), non-invasive nuclear radiopharmaceu...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X13666141204221238
更新日期:2014-12-01 00:00:00