Roles of TRAF6 in Central Nervous System.

abstract：BACKGROUND:The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. METHODS:A homology model of the transmembrane and extracellular regions of an Anophele...

journal_title：Current neuropharmacology

authors： Vinekar RS,Sowdhamini R

更新日期：2017-11-14 00:00:00

abstract：:To explore the functional consequences of cannabinoid withdrawal in the rat mesolimbic dopamine system, we investigated the anatomical morphology of the mesencephalic, presumed dopaminergic, neurons and their main post-synaptic target in the Nucleus Accumbens. We found that TH-positive neurons shrink and Golgi-stained...

journal_title：Current neuropharmacology

authors： Spiga S,Lintas A,Diana M

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The only conclusive way to diagnose Alzheimer's is to carry out brain autopsy of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other form of dementia. However, due to the non-feasibility of such methods, to diagnose and conclude the conditions, medical practitioners use ...

journal_title：Current neuropharmacology

authors： Khan S,Barve KH,Kumar MS

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is widely expressed in cells of the immune system such as T- and B-lymphocytes, mast cells, macrophages and microglia, but also found in dedifferentiated vascular smooth muscle cells, fibroblasts and many cancer cells including pancreatic, prostat...

journal_title：Current neuropharmacology

authors： Brown BM,Pressley B,Wulff H

更新日期：2018-01-01 00:00:00

abstract：:When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clini...

journal_title：Current neuropharmacology

authors： Smith BJ,St Louis EK,Stern JM,Green C,Bramley T

更新日期：2009-06-01 00:00:00

abstract：:The acronym TBI refers to traumatic brain injury, an alteration of brain function, or an evidence of brain pathology, that is caused by an external force. TBI is estimated to become the third leading cause of permanent disability and mortality worldwide. TBI-related injuries can be classified in many ways, according t...

journal_title：Current neuropharmacology

authors： Pinchi E,Frati P,Arcangeli M,Volonnino G,Tomassi R,Santoro P,Cipolloni L

更新日期：2020-01-01 00:00:00

abstract：:Sleep, an essential physiological process, has been divided into rapid eye movement sleep (REMS) and non-REMS (NREMS) in higher animals. REMS is a unique phenomenon that unlike other sleep-waking states is not under voluntary control. Directly or indirectly it influences or gets influenced by most of the physiological...

journal_title：Current neuropharmacology

authors： Mehta R,Singh A,Bókkon I,Nath Mallick B

更新日期：2016-01-01 00:00:00

abstract：:In the recent years we have been observing an increased incidence of type 1 diabetes in children and adolescents. This leads to a more frequent acute complication of type 1 diabetes among children with hyperglycemia. The most common of these is diabetic ketoacidosis (DKA), while cerebral edema is the most dangerous. I...

journal_title：Current neuropharmacology

authors： Szmygel Ł,Kosiak W,Zorena K,Myśliwiec M

更新日期：2016-01-01 00:00:00

abstract：:During the past decades Neural Stem Cells have been considered as an alternative source of cells to replace lost neurons and NSC transplantation has been indicated as a promising treatment for neurodegenerative disorders. Nevertheless, the current understanding of NSC biology suggests that, far from being mere spare p...

journal_title：Current neuropharmacology

authors： Carletti B,Piemonte F,Rossi F

更新日期：2011-06-01 00:00:00

abstract：:Depression is a serious psychiatric illness that affects millions of people worldwide. Weeks of antidepressant therapy are required to relieve depressive symptoms, and new drugs are still being extensively researched. The latest studies have shown that in depression, there is an imbalance between the main excitatory (...

journal_title：Current neuropharmacology

authors： Mlyniec K

更新日期：2015-01-01 00:00:00

abstract：:General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia, and immobility; while they may also induce side effects lik...

journal_title：Current neuropharmacology

authors： Hao X,Ou M,Zhang D,Zhao W,Yang Y,Liu J,Yang H,Zhu T,Li Y,Zhou C

更新日期：2020-01-01 00:00:00

abstract：:In preclinical neuropharmacological research, molecular, cell-based, and systems using animals are well established. On the tissue level the situation is less comfortable, although during the last decades some effort went into establishing such systems, i.e. using slices of the vertebrate brain together with optical a...

journal_title：Current neuropharmacology

authors： V M Fde L,W H

更新日期：2014-09-01 00:00:00

abstract：:There are several studies investigating the effects of risperidone in autism, but many of these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated the effects of risperidone on five domains of Aberrant Behaviour Checklist (ABC) scale on Autism Spectrum Disorder (ASD), as w...

journal_title：Current neuropharmacology

authors： Mano-Sousa BJ,Pedrosa AM,Alves BC,Galduróz JCF,Belo VS,Chaves VE,Duarte-Almeida JM

更新日期：2020-05-29 00:00:00

abstract：:The heat shock protein (Hsp) family is an evolutionarily conserved system that is charged with preventing unfolded or misfolded proteins in the cell from aggregating. In Alzheimer's disease, extracellular accumulation of the amyloid β peptide (Aβ) and intracellular aggregation of the microtubule associated protein tau...

journal_title：Current neuropharmacology

authors： Abisambra JF,Jinwal UK,Jones JR,Blair LJ,Koren J 3rd,Dickey CA

更新日期：2011-12-01 00:00:00

abstract：:Drug addiction results from the interplay between social and biological factors. Among these, genetic variables play a major role. The use of genetically related inbred rat strains that differ in their preference for drugs of abuse is one approach of great importance to explore genetic determinants. Lewis and Fischer ...

journal_title：Current neuropharmacology

authors： Higuera-Matas A,Montoya GL,Coria SM,Miguéns M,García-Lecumberri C,Ambrosio E

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucid...

journal_title：Current neuropharmacology

authors： Marichal-Cancino BA,Fajardo-Valdez A,Ruiz-Contreras AE,Mendez-Díaz M,Prospero-García O

更新日期：2017-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is the principal cause of invalidity and death in the population under 45 years of age worldwide. This mini-review aims to systematize the forensic approach in neuropathological studies, highlighting the proper elements to be noted during external, radiological, autoptical, and histologica...

journal_title：Current neuropharmacology

authors： Bertozzi G,Maglietta F,Sessa F,Scoto E,Cipolloni L,Di Mizio G,Salerno M,Pomara C

更新日期：2020-01-01 00:00:00

abstract：:Neurodegeneration is an initial process in the development of diabetic retinopathy (DR). High quantities of glutamate, oxidative stress, induction of the renin-angiotensin system (RAS) and elevated levels of RAGE are crucial elements in the retinal neurodegeneration caused by diabetes mellitus. At least, there is emer...

journal_title：Current neuropharmacology

authors： Iwona BS

更新日期：2016-01-01 00:00:00

abstract：:Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage inflicted is usually a consequence of the ability of these toxic agents to induce free radical generation within cells but especially at the level of the mitochondria. The elevated production of oxygen and nitrogen-based radical...

journal_title：Current neuropharmacology

authors： Reiter RJ,Manchester LC,Tan DX

更新日期：2010-09-01 00:00:00

abstract：:New psychoactive substances (NPS) have completely modified the drug scene and the current landscape of addiction. Synthetic substances, such as substituted or synthetic cathinones, also known as « legal highs », are often produced and used to mimic the effects of controlled drugs such as cocaine, methylenedioxymethamp...

journal_title：Current neuropharmacology

authors： Karila L,Megarbane B,Cottencin O,Lejoyeux M

更新日期：2015-01-01 00:00:00

abstract：:Although originally proposed as a subtype of opioid receptors, the sigma receptor is now confirmed to be a non-opioid receptor that binds diverse classes of psychotropic drugs. Sigma receptors are subdivided into two subtypes, sigma-1 and sigma-2. The sigma-1 receptor is a 25-kDa protein possessing one putative transm...

journal_title：Current neuropharmacology

authors： Hayashi T,Su T

更新日期：2005-10-01 00:00:00

abstract：:Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome (CFS) has been classified as a disease of the central nervous system by the WHO since 1969. Many patients carrying this diagnosis do demonstrate an almost bewildering array of biological abnormalities particularly the presence of oxidative and nitrosative stres...

journal_title：Current neuropharmacology

authors： Morris G,Maes M

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Congenital myasthenic syndromes (CMSs) are a heterogeneous group of neuromuscular disorders. Mutations of the nicotinic acetylcholine receptor epsilon subunit gene (CHRNE) are the most common causes of these disorders. CMSs are gaining increasing recognition by clinicians. However, pharmacological treatment ...

journal_title：Current neuropharmacology

authors： Huang K,Luo YB,Bi FF,Yang H

更新日期：2020-07-28 00:00:00

abstract：:Amphetamines exert their persistent addictive effects by activating brain's reward pathways, perhaps through the release of dopamine in the nucleus accumbens (and/or in other places). On the other hand, there is a relationship between dopamine and all behavioural aspects that involve motor activity and it has been dem...

journal_title：Current neuropharmacology

authors： Fontes-Ribeiro CA,Marques E,Pereira FC,Silva AP,Macedo TR

更新日期：2011-03-01 00:00:00

abstract：:Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lo...

journal_title：Current neuropharmacology

authors： Li D,Ni H,Rui Q,Gao R,Chen G

更新日期：2018-01-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are i...

journal_title：Current neuropharmacology

authors： Zoli M,Pucci S,Vilella A,Gotti C

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Both prescription and over-the-counter (OTC) drugs recently emerged among novel psychoactive substances (NPS) being reported as ingested for recreational purposes. Among them, benzydamine (BZY), normally prescribed as an OTC anti-inflammatory drug, is reportedly being diverted and recreationally used. OBJEC...

journal_title：Current neuropharmacology

authors： Stefania C,Andrea M,Alessio M,Mauro P,Amira G,Martin CJ,Giovanni M,Massimo DG,Fabrizio S

更新日期：2021-01-13 00:00:00

abstract：:Eicosanoids are arachidonic acid (AA) derivatives belonging to a family of lipid signalling mediators that are engaged in both physiological and pathological processes in the brain. Recently, their implication in the prolonged inflammatory response has become a focus of particular interest because, in contrast to acut...

journal_title：Current neuropharmacology

authors： Regulska M,Szuster-Głuszczak M,Trojan E,Leśkiewicz M,Basta-Kaim A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Hereditary cerebellar ataxias are a group of disorders characterized by heterogeneous clinical manifestations, progressive clinical course, and diverse genetic causes. No disease modifying treatments are yet available for many of these disorders. Oxidative stress has been recurrently identified in different ...

journal_title：Current neuropharmacology

authors： Barca E,Emmanuele V,DiMauro S,Toscano A,Quinzii CM

更新日期：2019-01-01 00:00:00

abstract：:Alzheimer's disease is one of the most progressive forms of dementia, ultimately leading to death in aged populations. The major hallmarks of Alzheimer's disease include deposition of extracellular amyloid senile plaques and intracellular neurofibrillary tangles in brain neuronal cells. Although there are classical th...

journal_title：Current neuropharmacology

authors： Singh RK

更新日期：2020-01-01 00:00:00