Abstract:
:The heat shock protein (Hsp) family is an evolutionarily conserved system that is charged with preventing unfolded or misfolded proteins in the cell from aggregating. In Alzheimer's disease, extracellular accumulation of the amyloid β peptide (Aβ) and intracellular aggregation of the microtubule associated protein tau may result from mechanisms involving chaperone proteins like the Hsps. Due to the ability of Hsps to regulate aberrantly accumulating proteins like Aβ and tau, therapeutic strategies are emerging that target this family of chaperones to modulate their pathobiology. This article focuses on the use of Hsp-based therapeutics for treating primary and secondary tauopathies like Alzheimer's disease. It will particularly focus on the pharmacological targeting of the Hsp70/90 system and the value of manipulating Hsp27 for treating Alzheimer's disease.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Abisambra JF,Jinwal UK,Jones JR,Blair LJ,Koren J 3rd,Dickey CAdoi
10.2174/157015911798376226subject
Has Abstractpub_date
2011-12-01 00:00:00pages
623-31issue
4eissn
1570-159Xissn
1875-6190pii
CN-9-623journal_volume
9pub_type
杂志文章abstract::Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome (CFS) has been classified as a disease of the central nervous system by the WHO since 1969. Many patients carrying this diagnosis do demonstrate an almost bewildering array of biological abnormalities particularly the presence of oxidative and nitrosative stres...
journal_title:Current neuropharmacology
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doi:10.2174/1570159X11666131120224653
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2007-01-01 00:00:00
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2008-09-01 00:00:00
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-01-01 00:00:00
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更新日期:2010-12-01 00:00:00
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更新日期:2010-09-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2011-03-01 00:00:00
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更新日期:2017-01-01 00:00:00
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更新日期:2014-05-01 00:00:00
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更新日期:2011-09-01 00:00:00
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更新日期:2016-01-01 00:00:00