Potential effects of cannabidiol as a wake-promoting agent.

Abstract:

:Over the last decades, the scientific interest in chemistry and pharmacology of cannabinoids has increased. Most attention has focused on ∆(9)-tetrahydrocannabinol (∆(9)-THC) as it is the psychoactive constituent of Cannabis sativa (C. sativa). However, in previous years, the focus of interest in the second plant constituent with non-psychotropic properties, cannabidiol (CBD) has been enhanced. Recently, several groups have investigated the pharmacological properties of CBD with significant findings; furthermore, this compound has raised promising pharmacological properties as a wake-inducing drug. In the current review, we will provide experimental evidence regarding the potential role of CBD as a wake-inducing drug.

journal_name

Curr Neuropharmacol

authors

Murillo-Rodríguez E,Sarro-Ramírez A,Sánchez D,Mijangos-Moreno S,Tejeda-Padrón A,Poot-Aké A,Guzmán K,Pacheco-Pantoja E,Arias-Carrión O

doi

10.2174/1570159X11666131204235805

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

269-72

issue

3

eissn

1570-159X

issn

1875-6190

pii

CN-12-281

journal_volume

12

pub_type

杂志文章
  • REM sleep and its Loss-Associated Epigenetic Regulation with Reference to Noradrenaline in Particular.

    abstract::Sleep, an essential physiological process, has been divided into rapid eye movement sleep (REMS) and non-REMS (NREMS) in higher animals. REMS is a unique phenomenon that unlike other sleep-waking states is not under voluntary control. Directly or indirectly it influences or gets influenced by most of the physiological...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159x13666150414185737

    authors: Mehta R,Singh A,Bókkon I,Nath Mallick B

    更新日期:2016-01-01 00:00:00

  • Rat Ultrasonic Vocalizations and Behavioral Neuropharmacology: From the Screening of Drugs to the Study of Disease.

    abstract::Several lines of evidence indicate that rats emit ultrasonic vocalizations (USVs) in response to a wide range of stimuli that are capable of producing either euphoric (positive) or dysphoric (negative) emotional states. On these bases, recordings of USVs are extensively used in preclinical studies of affect, motivatio...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159x13999150318113800

    authors: Simola N

    更新日期:2015-01-01 00:00:00

  • MicroRNAs: The New Challenge for Traumatic Brain Injury Diagnosis.

    abstract::The acronym TBI refers to traumatic brain injury, an alteration of brain function, or an evidence of brain pathology, that is caused by an external force. TBI is estimated to become the third leading cause of permanent disability and mortality worldwide. TBI-related injuries can be classified in many ways, according t...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X17666191113100808

    authors: Pinchi E,Frati P,Arcangeli M,Volonnino G,Tomassi R,Santoro P,Cipolloni L

    更新日期:2020-01-01 00:00:00

  • The Effects of General Anesthetics on Synaptic Transmission.

    abstract::General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia, and immobility; while they may also induce side effects lik...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X18666200227125854

    authors: Hao X,Ou M,Zhang D,Zhao W,Yang Y,Liu J,Yang H,Zhu T,Li Y,Zhou C

    更新日期:2020-01-01 00:00:00

  • Tuning and fine-tuning of synapses with adenosine.

    abstract::The 'omnipresence' of adenosine in all nervous system cells (neurons and glia) together with the intensive release of adenosine following insults, makes adenosine as a sort of 'maestro' of synapses leading to the homeostatic coordination of brain function. Besides direct actions of adenosine on the neurosecretory mech...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015909789152128

    authors: Sebastião AM,Ribeiro JA

    更新日期:2009-09-01 00:00:00

  • Presynaptic Release-regulating Metabotropic Glutamate Receptors: An Update.

    abstract::Metabotropic glutamate (mGlu) receptors represent the largest family of glutamate receptors in mammals and act as fine tuners of the chemical transmission in central nervous system (CNS). In the last decade, results concerning the expression and the subcellular localization of mGlu receptors further clarified their ro...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X17666191127112339

    authors: Olivero G,Vergassola M,Cisani F,Roggeri A,Pittaluga A

    更新日期:2020-01-01 00:00:00

  • Mesenchymal stem cells for treatment of CNS injury.

    abstract::Brain and spinal cord injuries present significant therapeutic challenges. The treatments available for these conditions are largely ineffective, partly due to limitations in directly targeting the therapeutic agents to sites of pathology within the central nervous system (CNS). The use of stem cells to treat these co...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015910793358204

    authors: Azari MF,Mathias L,Ozturk E,Cram DS,Boyd RL,Petratos S

    更新日期:2010-12-01 00:00:00

  • Relevance of excitable media theory and retinal spreading depression experiments in preclinical pharmacological research.

    abstract::In preclinical neuropharmacological research, molecular, cell-based, and systems using animals are well established. On the tissue level the situation is less comfortable, although during the last decades some effort went into establishing such systems, i.e. using slices of the vertebrate brain together with optical a...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X12666140630190800

    authors: V M Fde L,W H

    更新日期:2014-09-01 00:00:00

  • Traumatic Brain Injury: A Forensic Approach: A Literature Review.

    abstract::Traumatic brain injury (TBI) is the principal cause of invalidity and death in the population under 45 years of age worldwide. This mini-review aims to systematize the forensic approach in neuropathological studies, highlighting the proper elements to be noted during external, radiological, autoptical, and histologica...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X17666191101123145

    authors: Bertozzi G,Maglietta F,Sessa F,Scoto E,Cipolloni L,Di Mizio G,Salerno M,Pomara C

    更新日期:2020-01-01 00:00:00

  • Pharmacological Tools to Activate Microglia and their Possible use to Study Neural Network Patho-physiology.

    abstract:BACKGROUND:Microglia are the resident immunocompetent cells of the CNS and also constitute a unique cell type that contributes to neural network homeostasis and function. Understanding microglia cell-signaling not only will reveal their diverse functions but also will help to identify pharmacological and non-pharmacolo...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X14666160928151546

    authors: Pena-Ortega F

    更新日期:2017-01-01 00:00:00

  • Enhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice.

    abstract::MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway,...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015911795016985

    authors: Takamatsu Y,Shiotsuki H,Kasai S,Sato S,Iwamura T,Hattori N,Ikeda K

    更新日期:2011-03-01 00:00:00

  • One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke.

    abstract::Tissue plasminogen activator (t-PA) is the only FDA-approved drug for acute ischemic stroke treatment, but its clinical use is limited due to the narrow therapeutic time window and severe adverse effects, including hemorrhagic transformation (HT) and neurotoxicity. One of the potential resolutions is to use adjunct th...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159x14666160620102055

    authors: Chen HS,Qi SH,Shen JG

    更新日期:2017-01-01 00:00:00

  • Autoimmune channelopathies of the nervous system.

    abstract::Ion channels are complex transmembrane proteins that orchestrate the electrical signals necessary for normal function of excitable tissues, including the central nervous system, peripheral nerve, and both skeletal and cardiac muscle. Progress in molecular biology has allowed cloning and expression of genes that encode...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015911796557966

    authors: Kleopa KA

    更新日期:2011-09-01 00:00:00

  • Deciphering Subtype-Selective Modulations in TRPA1 Biosensor Channels.

    abstract::The transient receptor potential (TRP) proteins are a family of ion channels that act as cellular sensors. Several members of the TRP family are sensitive to oxidative stress mediators. Among them, TRPA1 is remarkably susceptible to various oxidants, and is known to mediate neuropathic pain and respiratory, vascular a...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159x1302150525122020

    authors: Kozai D,Sakaguchi R,Ohwada T,Mori Y

    更新日期:2015-01-01 00:00:00

  • The sigma receptor: evolution of the concept in neuropsychopharmacology.

    abstract::Although originally proposed as a subtype of opioid receptors, the sigma receptor is now confirmed to be a non-opioid receptor that binds diverse classes of psychotropic drugs. Sigma receptors are subdivided into two subtypes, sigma-1 and sigma-2. The sigma-1 receptor is a 25-kDa protein possessing one putative transm...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015905774322516

    authors: Hayashi T,Su T

    更新日期:2005-10-01 00:00:00

  • Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy.

    abstract::As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery o...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X11311040004

    authors: Murray AP,Faraoni MB,Castro MJ,Alza NP,Cavallaro V

    更新日期:2013-07-01 00:00:00

  • Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics.

    abstract::The heat shock protein (Hsp) family is an evolutionarily conserved system that is charged with preventing unfolded or misfolded proteins in the cell from aggregating. In Alzheimer's disease, extracellular accumulation of the amyloid β peptide (Aβ) and intracellular aggregation of the microtubule associated protein tau...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015911798376226

    authors: Abisambra JF,Jinwal UK,Jones JR,Blair LJ,Koren J 3rd,Dickey CA

    更新日期:2011-12-01 00:00:00

  • Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions.

    abstract::From the initial characterizations of inflammatory responses in Alzheimer's disease (AD) affected brains, namely the demonstration of activated microglia and reactive astrocytes, complement system activation, increased production of proinflammatory cytokines, and evidence for microglial-produced neurotoxins, there was...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/157015907782793667

    authors: Walker D,Lue LF

    更新日期:2007-12-01 00:00:00

  • Systematic Review of Food Addiction as Measured with the Yale Food Addiction Scale: Implications for the Food Addiction Construct.

    abstract:BACKGROUND:The concept of food addiction attracts much interest in the scientific community. Research is mainly based on the Yale Food Addiction Scale (YFAS), a tool developed to assess food addiction. Substance use disorder criteria have been used to develop this scale. OBJECTIVE:The aim of this paper was to review t...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,meta分析

    doi:10.2174/1570159X16666181108093520

    authors: Penzenstadler L,Soares C,Karila L,Khazaal Y

    更新日期:2019-01-01 00:00:00

  • The benzydamine experience: a systematic review of benzydamine abuse.

    abstract:BACKGROUND:Both prescription and over-the-counter (OTC) drugs recently emerged among novel psychoactive substances (NPS) being reported as ingested for recreational purposes. Among them, benzydamine (BZY), normally prescribed as an OTC anti-inflammatory drug, is reportedly being diverted and recreationally used. OBJEC...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X19666210113151136

    authors: Stefania C,Andrea M,Alessio M,Mauro P,Amira G,Martin CJ,Giovanni M,Massimo DG,Fabrizio S

    更新日期:2021-01-13 00:00:00

  • Cannabidiol Adverse Effects and Toxicity.

    abstract:BACKGROUND:Currently, there is a great interest in the potential medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid system. Multiple preclinical and clinical studies l...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X17666190603171901

    authors: Huestis MA,Solimini R,Pichini S,Pacifici R,Carlier J,Busardò FP

    更新日期:2019-01-01 00:00:00

  • Temozolomide: An Updated Overview of Resistance Mechanisms, Nanotechnology Advances and Clinical Applications.

    abstract::Temozolomide (TMZ), an oral alkylating prodrug which delivers a methyl group to purine bases of DNA (O6- guanine; N7-guanine and N3-adenine), is frequently used together with radiotherapy as part of the first-line treatment of high-grade gliomas. The main advantages are its high oral bioavailability (almost 100% altho...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X18666200626204005

    authors: Ortiz R,Perazzoli G,Cabeza L,Jiménez-Luna C,Luque R,Prados J,Melguizo C

    更新日期:2020-06-26 00:00:00

  • Putative Involvement of Endocrine Disruptors in the Alzheimer's disease Via the Insulin-Regulated Aminopeptidase / GLUT4 Pathway.

    abstract::It has been well established that there is a connection between type II diabetes (DMTII) and Alzheimer's disease (AD). In fact, the increase in AD incidence may be an emerging complication of DMTII. Both pathologies are related to estradiol (E2) exposure on the one hand, estrogen receptors (ER) are emerging as importa...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X18666201111103024

    authors: Ramírez-Expósito MJ,Martínez-Martos JM,Cantón-Habas V,Carrera González MP

    更新日期:2020-11-10 00:00:00

  • Tyrosol as a neuroprotector: strong effects of a "weak" antioxidant.

    abstract::The use of neuroprotective agents for stroke is pathogenetically justified, but the translation of results of preclinical studies of neuroprotectors into clinical practice has been a noticeable failure. One of the leading reasons for these failures is the one-target mechanism of their activity. p-Tyrosol (Tyr), a biop...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X18666200507082311

    authors: Plotnikov MB,Plotnikova TM

    更新日期:2020-05-06 00:00:00

  • The Emerging Role of the Double-Edged Impact of Arachidonic Acid- Derived Eicosanoids in the Neuroinflammatory Background of Depression.

    abstract::Eicosanoids are arachidonic acid (AA) derivatives belonging to a family of lipid signalling mediators that are engaged in both physiological and pathological processes in the brain. Recently, their implication in the prolonged inflammatory response has become a focus of particular interest because, in contrast to acut...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X18666200807144530

    authors: Regulska M,Szuster-Głuszczak M,Trojan E,Leśkiewicz M,Basta-Kaim A

    更新日期:2021-01-01 00:00:00

  • Mesenchymal Stem Cells of Dental Origin-Their Potential for Antiinflammatory and Regenerative Actions in Brain and Gut Damage.

    abstract::Alzheimer's disease, Parkinson's disease, traumatic brain and spinal cord injury and neuroinflammatory multiple sclerosis are diverse disorders of the central nervous system. However, they are all characterized by various levels of inappropriate inflammatory/immune response along with tissue destruction. In the gastro...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159x14666160121115210

    authors: Földes A,Kádár K,Kerémi B,Zsembery Á,Gyires K,S Zádori Z,Varga G

    更新日期:2016-01-01 00:00:00

  • Recent Advances in Pathophysiology of Traumatic Brain Injury.

    abstract:BACKGROUND:Traumatic brain injury (TBI) constitutes the primary reason for mortality and morbidity in persons worldwide below 45 years of age. 1.7 million Traumatic events occur yearly in the United States alone, considering for 50,000 deaths. In severe traumatic brain injury sufferers, a considerable achievement attai...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X15666170613083606

    authors: Kaur P,Sharma S

    更新日期:2018-01-01 00:00:00

  • Mechanisms in the bed nucleus of the stria terminalis involved in control of autonomic and neuroendocrine functions: a review.

    abstract::The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought to serve as a key relay connecting limbic forebrain structures to hypothalamic and brainstem reg...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章

    doi:10.2174/1570159X11311020002

    authors: Crestani CC,Alves FH,Gomes FV,Resstel LB,Correa FM,Herman JP

    更新日期:2013-03-01 00:00:00

  • From Randomized Controlled Trials of Antidepressant Drugs to the Meta-Analytic Synthesis of Evidence: Methodological Aspects Lead to Discrepant Findings.

    abstract::During the last decade, several meta-analytic studies employing different methodological approaches have had inconsistent conclusions regarding antidepressant efficacy. Herein, we aim to comment on methodological aspects that may have contributed to disparate findings. We initially discuss methodological inconsistenci...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,meta分析

    doi:10.2174/1570159x13666150630174343

    authors: Fountoulakis KN,McIntyre RS,Carvalho AF

    更新日期:2015-01-01 00:00:00

  • Pediatric Mania: The Controversy between Euphoria and Irritability.

    abstract::Pediatric Bipolar Disorder (BD) is a highly morbid pediatric psychiatric disease, consistently associated with family psychiatric history of mood disorders and associated with high levels of morbidity and disability and with a great risk of suicide. While there is a general consensus on the symptomatology of depressio...

    journal_title:Current neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570159X14666160607100403

    authors: Serra G,Uchida M,Battaglia C,Casini MP,De Chiara L,Biederman J,Vicari S,Wozniak J

    更新日期:2017-04-01 00:00:00