Abstract:
:Diffuse intrinsic pontine gliomas (DIPGs) are invariably fatal tumors found in the pons of elementary school aged children. These tumors are grade II-IV gliomas, with a median survival of less than 1 year from diagnosis when treated with standard of care (SOC) therapy. Nanotechnology may offer therapeutic options for the treatment of DIPGs. Multiple nanoparticle formulations are currently being investigated for the treatment of DIPGs. Nanoparticles based upon stable elements, polymer nanoparticles, and organic nanoparticles are under development for the treatment of brain tumors, including DIPGs. Targeting of nanoparticles is now possible as delivery techniques that address the difficulty in crossing the blood brain barrier (BBB) are developed. Theranostic nanoparticles, a combination of therapeutics and diagnostic nanoparticles, improve imaging of the cancerous tissue while delivering therapy to the local region. However, additional time and attention should be directed to developing a nanoparticle delivery system for treatment of the uniformly fatal pediatric disease of DIPG.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Bredlau AL,Dixit S,Chen C,Broome AMdoi
10.2174/1570159x14666160223121002subject
Has Abstractpub_date
2017-01-01 00:00:00pages
104-115issue
1eissn
1570-159Xissn
1875-6190pii
CN-EPUB-73892journal_volume
15pub_type
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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pub_type: 杂志文章,meta分析
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journal_title:Current neuropharmacology
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