Abstract:
BACKGROUND:Microglia are the resident immunocompetent cells of the CNS and also constitute a unique cell type that contributes to neural network homeostasis and function. Understanding microglia cell-signaling not only will reveal their diverse functions but also will help to identify pharmacological and non-pharmacological tools to modulate the activity of these cells. METHODS:We undertook a search of bibliographic databases for peer-reviewed research literature to identify microglial activators and their cell-specificity. We also looked for their effects on neural network function and dysfunction. RESULTS:We identified several pharmacological targets to modulate microglial function, which are more or less specific (with the proper control experiments). We also identified pharmacological targets that would require the development of new potent and specific modulators. We identified a wealth of evidence about the participation of microglia in neural network function and their alterations in pathological conditions. CONCLUSION:The identification of specific microglia-activating signals provides experimental tools to modulate the activity of this heterogeneous cell type in order to evaluate its impact on other components of the nervous system, and it also helps to identify therapeutic approaches to ease some pathological conditions related to microglial dysfunction.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Pena-Ortega Fdoi
10.2174/1570159X14666160928151546subject
Has Abstractpub_date
2017-01-01 00:00:00pages
595-619issue
4eissn
1570-159Xissn
1875-6190pii
CN-EPUB-78656journal_volume
15pub_type
杂志文章,评审abstract::Peripheral neuropathies are a heterogeneous group of diseases affecting peripheral nerves. The causes are multiple: hereditary, metabolic, infectious, inflammatory, toxic, traumatic. The temporal profile includes acute, subacute and chronic conditions. The majority of peripheral neuropathies cause mainly muscle weakne...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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doi:10.2174/157015911795596603
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journal_title:Current neuropharmacology
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doi:10.2174/1570159x14666160106155129
更新日期:2016-01-01 00:00:00
abstract::The acronym TBI refers to traumatic brain injury, an alteration of brain function, or an evidence of brain pathology, that is caused by an external force. TBI is estimated to become the third leading cause of permanent disability and mortality worldwide. TBI-related injuries can be classified in many ways, according t...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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abstract::The push-pull superfusion technique (PPST) is a procedure for in vivo examination of transmitter release in distinct brain areas. This technique allows to investigate dynamics of transmitter release both under normal and experimentally evoked conditions. The PPST can be modified so that it is possible to determine rel...
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更新日期:2016-01-01 00:00:00
abstract::Neurodegeneration is an initial process in the development of diabetic retinopathy (DR). High quantities of glutamate, oxidative stress, induction of the renin-angiotensin system (RAS) and elevated levels of RAGE are crucial elements in the retinal neurodegeneration caused by diabetes mellitus. At least, there is emer...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2009-12-01 00:00:00
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更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Diabetic retinopathy (DR) is an important complication of diabetes and is considered one of the main causes of blindness in moderate-income and highly-developed countries. As it is a major socioeconomic problem, defining all mechanisms that may lead to DR development is of great importance. In the 21st centu...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current neuropharmacology
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