Abstract:
:As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme AChE, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with Alzheimer's disease and alleviating the symptoms of this neurological disorder. This review summarizes a total of 128 studies which correspond to the most relevant research work published during 2006-2012 (1st semester) on plant-derived compounds, plant extracts and essential oils found to elicit AChE inhibition.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Murray AP,Faraoni MB,Castro MJ,Alza NP,Cavallaro Vdoi
10.2174/1570159X11311040004subject
Has Abstractpub_date
2013-07-01 00:00:00pages
388-413issue
4eissn
1570-159Xissn
1875-6190pii
CN-11-388journal_volume
11pub_type
杂志文章abstract::Tissue plasminogen activator (t-PA) is the only FDA-approved drug for acute ischemic stroke treatment, but its clinical use is limited due to the narrow therapeutic time window and severe adverse effects, including hemorrhagic transformation (HT) and neurotoxicity. One of the potential resolutions is to use adjunct th...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160620102055
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abstract::Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often life-threatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR)...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:Current neuropharmacology
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abstract::Traumatic brain injury (TBI) is the principal cause of invalidity and death in the population under 45 years of age worldwide. This mini-review aims to systematize the forensic approach in neuropathological studies, highlighting the proper elements to be noted during external, radiological, autoptical, and histologica...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2021-01-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2013-09-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2011-03-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2020-05-06 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2005-10-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2020-06-26 00:00:00
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journal_title:Current neuropharmacology
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doi:10.2174/157015911795016985
更新日期:2011-03-01 00:00:00
abstract::Diffuse intrinsic pontine gliomas (DIPGs) are invariably fatal tumors found in the pons of elementary school aged children. These tumors are grade II-IV gliomas, with a median survival of less than 1 year from diagnosis when treated with standard of care (SOC) therapy. Nanotechnology may offer therapeutic options for ...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160223121002
更新日期:2017-01-01 00:00:00
abstract::The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought to serve as a key relay connecting limbic forebrain structures to hypothalamic and brainstem reg...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X11311020002
更新日期:2013-03-01 00:00:00
abstract::Long-term potentiation (LTP) and long-term depression (LTD) are two distinct forms of synaptic plasticity that have been extensively characterized at the Schaffer collateral-CA1 (SCCA1) synapse and the mossy fiber (MF)-CA3 synapse within the hippocampus, and are postulated to be the molecular underpinning for several ...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x13666150421003225
更新日期:2016-01-01 00:00:00
abstract::Parkinson's disease (PD) is a common progressive, neurodegenerative brain disease that is promoted by mitochondrial dysfunction, oxidative stress, protein aggregation and proteasome dysfunction in the brain. Compared with computer tomography (CT) or magnetic resonance imaging (MRI), non-invasive nuclear radiopharmaceu...
journal_title:Current neuropharmacology
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更新日期:2014-12-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2019-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Shared connections between physical activity and neuroprotection have been studied for decades, but the mechanisms underlying this effect of specific exercise were only recently brought to light. Several evidences suggest that physical activity may be a reasonable and beneficial method to improve functional ...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are i...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
abstract::General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia, and immobility; while they may also induce side effects lik...
journal_title:Current neuropharmacology
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更新日期:2020-01-01 00:00:00
abstract::Ion channels are complex transmembrane proteins that orchestrate the electrical signals necessary for normal function of excitable tissues, including the central nervous system, peripheral nerve, and both skeletal and cardiac muscle. Progress in molecular biology has allowed cloning and expression of genes that encode...
journal_title:Current neuropharmacology
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更新日期:2011-09-01 00:00:00
abstract::Depression is a serious psychiatric illness that affects millions of people worldwide. Weeks of antidepressant therapy are required to relieve depressive symptoms, and new drugs are still being extensively researched. The latest studies have shown that in depression, there is an imbalance between the main excitatory (...
journal_title:Current neuropharmacology
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更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. METHODS:A homology model of the transmembrane and extracellular regions of an Anophele...
journal_title:Current neuropharmacology
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更新日期:2017-11-14 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Congenital myasthenic syndromes (CMSs) are a heterogeneous group of neuromuscular disorders. Mutations of the nicotinic acetylcholine receptor epsilon subunit gene (CHRNE) are the most common causes of these disorders. CMSs are gaining increasing recognition by clinicians. However, pharmacological treatment ...
journal_title:Current neuropharmacology
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更新日期:2020-07-28 00:00:00
abstract::When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clini...
journal_title:Current neuropharmacology
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更新日期:2009-06-01 00:00:00