Abstract:
:New psychoactive substances (NPS) have completely modified the drug scene and the current landscape of addiction. Synthetic substances, such as substituted or synthetic cathinones, also known as « legal highs », are often produced and used to mimic the effects of controlled drugs such as cocaine, methylenedioxymethamphetamine (MDMA, ecstasy), and methamphetamine. The overwhelming majority of synthetic cathinones are produced in China and South East Asian countries. The Internet has emerged as the new marketplace for NPS, playing a major role in providing information on acquisition, synthesis, extraction, identification, and substance use. All these compounds are intentionally mislabeled and sold on-line under slang terms such as bath salts, plant food, plant feeders and research chemicals. They are sometimes labeled « not for human use » or « not tested for hazards or toxicity ». The rapid spread of NPS forces member countries of the European Union to adapt their response to the potential new dangers that may cause. To date, not only health actors but also the general public need to be clearly informed and aware of dangers resulting from NPS spread and use. Here, we review the major clinical effects of synthetic cathinones to highlight their impact on public health. A literature search was conducted from 2009 to 2014 based on PubMed, Google Scholar, Erowid, and governmental websites, using the following keywords alone or in combination: "new psychoactive substances", "synthetic cathinones", "substituted cathinones", "mephedrone", "methylone", "MDPV", "4-MEC", "addiction", and "substance use disorder".
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Karila L,Megarbane B,Cottencin O,Lejoyeux Mdoi
10.2174/1570159X13666141210224137subject
Has Abstractpub_date
2015-01-01 00:00:00pages
12-20issue
1eissn
1570-159Xissn
1875-6190pii
CN-13-12journal_volume
13pub_type
杂志文章,评审abstract::It is well recognized the role of the Wnt pathway in many developmental processes such as neuronal maturation, migration, neuronal connectivity and synaptic formation. Growing evidence is also demonstrating its function in the mature brain where is associated with modulation of axonal remodeling, dendrite outgrowth, s...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2009-12-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2011-03-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2011-03-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2020-06-26 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X14666160330105132
更新日期:2017-01-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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journal_title:Current neuropharmacology
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更新日期:2007-01-01 00:00:00
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2015-01-01 00:00:00