Abstract:
:Animal behavioural profiles are commonly employed to investigate new therapeutic agents to treat anxiety disorders as well as to investigate the mechanism of action of anxiolytic drugs. However, many clinically important symptoms of anxiety can not be modelled directly in animals. Human models of anxiety should bridge between animal models and anxiety disorders. Experimental anxiety states in humans can be induced by either pharmacological means such as CO(2) inhalation or psychological means such as aversive conditioning of skin conductance responses to tones. Investigation of these models may contribute to a better understanding of anxiety disorders, both from a biological and behavioural point of view. In a comprehensive review existing models of human experimental anxiety states are summarized and validity is discussed.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Siepmann M,Joraschky Pdoi
10.2174/157015907780077114subject
Has Abstractpub_date
2007-03-01 00:00:00pages
65-72issue
1eissn
1570-159Xissn
1875-6190journal_volume
5pub_type
杂志文章abstract:BACKGROUND:The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor that awaits a formal classification. There are an increasing number of reports directed to know the physiology and pathophysiology of this receptor. Lamentably, its functions in the central nervous system (CNS) have been scarcely elucid...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X14666160729155441
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Currently, there is a great interest in the potential medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid system. Multiple preclinical and clinical studies l...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666190603171901
更新日期:2019-01-01 00:00:00
abstract::In preclinical neuropharmacological research, molecular, cell-based, and systems using animals are well established. On the tissue level the situation is less comfortable, although during the last decades some effort went into establishing such systems, i.e. using slices of the vertebrate brain together with optical a...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X12666140630190800
更新日期:2014-09-01 00:00:00
abstract::Peripheral neuropathies are a heterogeneous group of diseases affecting peripheral nerves. The causes are multiple: hereditary, metabolic, infectious, inflammatory, toxic, traumatic. The temporal profile includes acute, subacute and chronic conditions. The majority of peripheral neuropathies cause mainly muscle weakne...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015906778019536
更新日期:2006-07-01 00:00:00
abstract::The transient receptor potential (TRP) proteins are a family of ion channels that act as cellular sensors. Several members of the TRP family are sensitive to oxidative stress mediators. Among them, TRPA1 is remarkably susceptible to various oxidants, and is known to mediate neuropathic pain and respiratory, vascular a...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x1302150525122020
更新日期:2015-01-01 00:00:00
abstract::During the past decades Neural Stem Cells have been considered as an alternative source of cells to replace lost neurons and NSC transplantation has been indicated as a promising treatment for neurodegenerative disorders. Nevertheless, the current understanding of NSC biology suggests that, far from being mere spare p...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015911795596603
更新日期:2011-06-01 00:00:00
abstract::Neurodegeneration is an initial process in the development of diabetic retinopathy (DR). High quantities of glutamate, oxidative stress, induction of the renin-angiotensin system (RAS) and elevated levels of RAGE are crucial elements in the retinal neurodegeneration caused by diabetes mellitus. At least, there is emer...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160813182009
更新日期:2016-01-01 00:00:00
abstract::Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often life-threatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR)...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015906776359586
更新日期:2006-04-01 00:00:00
abstract::Alzheimer's disease, Parkinson's disease, traumatic brain and spinal cord injury and neuroinflammatory multiple sclerosis are diverse disorders of the central nervous system. However, they are all characterized by various levels of inappropriate inflammatory/immune response along with tissue destruction. In the gastro...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160121115210
更新日期:2016-01-01 00:00:00
abstract::The acronym TBI refers to traumatic brain injury, an alteration of brain function, or an evidence of brain pathology, that is caused by an external force. TBI is estimated to become the third leading cause of permanent disability and mortality worldwide. TBI-related injuries can be classified in many ways, according t...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666191113100808
更新日期:2020-01-01 00:00:00
abstract::Pediatric Bipolar Disorder (BD) is a highly morbid pediatric psychiatric disease, consistently associated with family psychiatric history of mood disorders and associated with high levels of morbidity and disability and with a great risk of suicide. While there is a general consensus on the symptomatology of depressio...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X14666160607100403
更新日期:2017-04-01 00:00:00
abstract::The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought to serve as a key relay connecting limbic forebrain structures to hypothalamic and brainstem reg...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X11311020002
更新日期:2013-03-01 00:00:00
abstract::It is well recognized the role of the Wnt pathway in many developmental processes such as neuronal maturation, migration, neuronal connectivity and synaptic formation. Growing evidence is also demonstrating its function in the mature brain where is associated with modulation of axonal remodeling, dendrite outgrowth, s...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X11311050001
更新日期:2013-09-01 00:00:00
abstract::Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorders. Why these aggregates form remains unclear. Equally debated is whether they are toxic, protective, or simple by-products. Increasing evidence, however, supports the notion that in general aggregates confer toxicity a...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015908784533897
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Diabetic retinopathy (DR) is an important complication of diabetes and is considered one of the main causes of blindness in moderate-income and highly-developed countries. As it is a major socioeconomic problem, defining all mechanisms that may lead to DR development is of great importance. In the 21st centu...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160523144245
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. METHODS:A homology model of the transmembrane and extracellular regions of an Anophele...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1567201814666161205131213
更新日期:2017-11-14 00:00:00
abstract::The calcium (Ca(2+))-sensing receptor (CaR) belongs to family C of the G-protein coupled receptors (GPCRs). The receptor is activated by physiological levels of Ca(2+) (and Mg(2+)) and positively modulated by a range of proteinogenic L-alpha-amino acids. Recently, several synthetic allosteric modulators of the recepto...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015907781695982
更新日期:2007-09-01 00:00:00
abstract::Parkinson's disease (PD) is a common progressive, neurodegenerative brain disease that is promoted by mitochondrial dysfunction, oxidative stress, protein aggregation and proteasome dysfunction in the brain. Compared with computer tomography (CT) or magnetic resonance imaging (MRI), non-invasive nuclear radiopharmaceu...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X13666141204221238
更新日期:2014-12-01 00:00:00
abstract::Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins: the Aquaporins (AQPs). These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015910791233204
更新日期:2010-06-01 00:00:00
abstract::Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are i...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X15666170912110450
更新日期:2018-01-01 00:00:00
abstract::Brain and spinal cord injuries present significant therapeutic challenges. The treatments available for these conditions are largely ineffective, partly due to limitations in directly targeting the therapeutic agents to sites of pathology within the central nervous system (CNS). The use of stem cells to treat these co...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015910793358204
更新日期:2010-12-01 00:00:00
abstract::Tumor necrosis factor receptor-associated factor (TRAF) is an important binding protein of tumor necrosis factor (TNF) superfamily and the toll/IL-1 receptor (TIR) superfamily, which play an important role in innate immunity and acquired immunity. TRAFs family have 7 members (TRAF1-7), and TRAF6 has its special factur...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X16666180412094655
更新日期:2018-01-01 00:00:00
abstract::The push-pull superfusion technique (PPST) is a procedure for in vivo examination of transmitter release in distinct brain areas. This technique allows to investigate dynamics of transmitter release both under normal and experimentally evoked conditions. The PPST can be modified so that it is possible to determine rel...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x13666150722233149
更新日期:2015-01-01 00:00:00
abstract::Drug addiction results from the interplay between social and biological factors. Among these, genetic variables play a major role. The use of genetically related inbred rat strains that differ in their preference for drugs of abuse is one approach of great importance to explore genetic determinants. Lewis and Fischer ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015911795017290
更新日期:2011-03-01 00:00:00
abstract::During the last decade, several meta-analytic studies employing different methodological approaches have had inconsistent conclusions regarding antidepressant efficacy. Herein, we aim to comment on methodological aspects that may have contributed to disparate findings. We initially discuss methodological inconsistenci...
journal_title:Current neuropharmacology
pub_type: 杂志文章,meta分析
doi:10.2174/1570159x13666150630174343
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Microglia are the resident immunocompetent cells of the CNS and also constitute a unique cell type that contributes to neural network homeostasis and function. Understanding microglia cell-signaling not only will reveal their diverse functions but also will help to identify pharmacological and non-pharmacolo...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X14666160928151546
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The only conclusive way to diagnose Alzheimer's is to carry out brain autopsy of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other form of dementia. However, due to the non-feasibility of such methods, to diagnose and conclude the conditions, medical practitioners use ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200528142429
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Depression is among the commonest of psychiatric disorders, and inflammatory mechanisms have been suggested to play a role in its pathophysiology. Interferons are a superfamily of proinflammatory cytokines that play a role in host defence mechanisms. Interferons are used in the treatment of a variety of auto...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160106155129
更新日期:2016-01-01 00:00:00
abstract::Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lo...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X16666180516095949
更新日期:2018-01-01 00:00:00
abstract::Glutamate receptor, ionotropic, N-methyl-D-aspartate associated protein 1 (GRINA) is a member of the NMDA receptors (NMDARs) and is involved in several neurological diseases, which governs the key processes of neuronal cell death or the release of neurotransmitters. Upregulation of GRINA has been reported in multiple ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200303104235
更新日期:2020-01-01 00:00:00