Abstract:
:Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorders. Why these aggregates form remains unclear. Equally debated is whether they are toxic, protective, or simple by-products. Increasing evidence, however, supports the notion that in general aggregates confer toxicity and disturb neuronal function by hampering axonal transport, synaptic integrity, transcriptional regulation, and mitochondrial function. Thus, neuroscientists in search of effective treatments to slow neural loss during neurodegeneration have long been interested in finding new ways to clear inclusion bodies. Intriguingly, two studies using conditional neuron-specific gene ablations of autophagy regulators in mice revealed that autophagy loss elicits inclusion body formation and a neurodegenerative cascade.Such studies indicate autophagy may be a built-in defense mechanism to clear the nervous system of inclusion bodies.This new finding has implications for our understanding of aging and neurodegeneration and the development of new therapies. First, we discuss the pathways underlying autophagy and its controversial role in cell death and survival regulation.We then discuss the physiological role of autophagy in the aging process of the nervous system. In the final portion of this review, we discuss the therapeutic promise of inducing autophagy and the potential side effects of such treatments.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Bossy B,Perkins G,Bossy-Wetzel Edoi
10.2174/157015908784533897subject
Has Abstractpub_date
2008-06-01 00:00:00pages
97-101issue
2eissn
1570-159Xissn
1875-6190journal_volume
6pub_type
杂志文章abstract:BACKGROUND:The concept of food addiction attracts much interest in the scientific community. Research is mainly based on the Yale Food Addiction Scale (YFAS), a tool developed to assess food addiction. Substance use disorder criteria have been used to develop this scale. OBJECTIVE:The aim of this paper was to review t...
journal_title:Current neuropharmacology
pub_type: 杂志文章,meta分析
doi:10.2174/1570159X16666181108093520
更新日期:2019-01-01 00:00:00
abstract::Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lo...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X16666180516095949
更新日期:2018-01-01 00:00:00
abstract::Migraine, an extremely disabling neurological disorder, has a strong genetic component. Since monogenic migraines (resulting from mutations or changes in a single gene) may help researchers discover migraine pathophysiology, transgenic mice models harboring gene mutations identified in Familial Hemiplegic Migraine (FH...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666190513085013
更新日期:2019-01-01 00:00:00
abstract::Bacopa monnieri, commonly known as Brahmi, has been extensively used as a neuromedicine for various disorders such as anxiety, depression and memory loss. Chemical characterization studies revealed the major active constituents of the herb as the triterpenoid saponins, bacosides. Bacoside A, the vital neuroprotective ...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X16666180419123022
更新日期:2019-01-01 00:00:00
abstract::Tumor necrosis factor receptor-associated factor (TRAF) is an important binding protein of tumor necrosis factor (TNF) superfamily and the toll/IL-1 receptor (TIR) superfamily, which play an important role in innate immunity and acquired immunity. TRAFs family have 7 members (TRAF1-7), and TRAF6 has its special factur...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X16666180412094655
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Traumatic brain injury (TBI) constitutes the primary reason for mortality and morbidity in persons worldwide below 45 years of age. 1.7 million Traumatic events occur yearly in the United States alone, considering for 50,000 deaths. In severe traumatic brain injury sufferers, a considerable achievement attai...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X15666170613083606
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Currently, there is a great interest in the potential medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid system. Multiple preclinical and clinical studies l...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666190603171901
更新日期:2019-01-01 00:00:00
abstract::The acronym TBI refers to traumatic brain injury, an alteration of brain function, or an evidence of brain pathology, that is caused by an external force. TBI is estimated to become the third leading cause of permanent disability and mortality worldwide. TBI-related injuries can be classified in many ways, according t...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666191113100808
更新日期:2020-01-01 00:00:00
abstract::It is well recognized the role of the Wnt pathway in many developmental processes such as neuronal maturation, migration, neuronal connectivity and synaptic formation. Growing evidence is also demonstrating its function in the mature brain where is associated with modulation of axonal remodeling, dendrite outgrowth, s...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X11311050001
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:The treatment of schizophrenia is challenging due to the wide range of symptoms (positive, negative, cognitive) associated with the disease. Typical antipsychotics that antagonize D2 receptors are effective in treating positive symptoms, but extrapyramidal side-effects (EPS) are a common occurrence. Atypical...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X15666170413115754
更新日期:2017-11-14 00:00:00
abstract::In preclinical neuropharmacological research, molecular, cell-based, and systems using animals are well established. On the tissue level the situation is less comfortable, although during the last decades some effort went into establishing such systems, i.e. using slices of the vertebrate brain together with optical a...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X12666140630190800
更新日期:2014-09-01 00:00:00
abstract::Major depressive disorder (MDD) is estimated to impose maximum debilitating effects on the society by 2030, with its critical effects on health, functioning, quality of life and concomitant high levels of morbidity and mortality. Yet, the disease is inadequately understood, diagnosed and treated. Moreover, with the re...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666191001142934
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Congenital myasthenic syndromes (CMSs) are a heterogeneous group of neuromuscular disorders. Mutations of the nicotinic acetylcholine receptor epsilon subunit gene (CHRNE) are the most common causes of these disorders. CMSs are gaining increasing recognition by clinicians. However, pharmacological treatment ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200729092332
更新日期:2020-07-28 00:00:00
abstract::As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery o...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X11311040004
更新日期:2013-07-01 00:00:00
abstract::MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway,...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015911795016985
更新日期:2011-03-01 00:00:00
abstract::Ion channels are complex transmembrane proteins that orchestrate the electrical signals necessary for normal function of excitable tissues, including the central nervous system, peripheral nerve, and both skeletal and cardiac muscle. Progress in molecular biology has allowed cloning and expression of genes that encode...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015911796557966
更新日期:2011-09-01 00:00:00
abstract::Mood disorders such as major depression and bipolar disorder are common, severe, chronic and often life-threatening illnesses. Suicide is estimated to be the cause of death in up to approximately 10-15% of individuals with mood disorders. Alterations in the signal transduction through G protein-coupled receptor (GPCR)...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015906776359586
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Depression is among the commonest of psychiatric disorders, and inflammatory mechanisms have been suggested to play a role in its pathophysiology. Interferons are a superfamily of proinflammatory cytokines that play a role in host defence mechanisms. Interferons are used in the treatment of a variety of auto...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160106155129
更新日期:2016-01-01 00:00:00
abstract::Neurodegeneration is an initial process in the development of diabetic retinopathy (DR). High quantities of glutamate, oxidative stress, induction of the renin-angiotensin system (RAS) and elevated levels of RAGE are crucial elements in the retinal neurodegeneration caused by diabetes mellitus. At least, there is emer...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x14666160813182009
更新日期:2016-01-01 00:00:00
abstract::There are several studies investigating the effects of risperidone in autism, but many of these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated the effects of risperidone on five domains of Aberrant Behaviour Checklist (ABC) scale on Autism Spectrum Disorder (ASD), as w...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200529151741
更新日期:2020-05-29 00:00:00
abstract::New psychoactive substances (NPS) have completely modified the drug scene and the current landscape of addiction. Synthetic substances, such as substituted or synthetic cathinones, also known as « legal highs », are often produced and used to mimic the effects of controlled drugs such as cocaine, methylenedioxymethamp...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X13666141210224137
更新日期:2015-01-01 00:00:00
abstract::The heat shock protein (Hsp) family is an evolutionarily conserved system that is charged with preventing unfolded or misfolded proteins in the cell from aggregating. In Alzheimer's disease, extracellular accumulation of the amyloid β peptide (Aβ) and intracellular aggregation of the microtubule associated protein tau...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015911798376226
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a pot...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159X17666191021111809
更新日期:2020-01-01 00:00:00
abstract::Autophagy is a cellular quality control mechanism crucial for neuronal homeostasis. Defects in autophagy are critically associated with mechanisms underlying Parkinson's disease (PD), a common and debilitating neurodegenerative disorder. Autophagic dysfunction in PD can occur at several stages of the autophagy/lysosom...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570159x13666151030103027
更新日期:2016-01-01 00:00:00
abstract::Glutamate receptor, ionotropic, N-methyl-D-aspartate associated protein 1 (GRINA) is a member of the NMDA receptors (NMDARs) and is involved in several neurological diseases, which governs the key processes of neuronal cell death or the release of neurotransmitters. Upregulation of GRINA has been reported in multiple ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200303104235
更新日期:2020-01-01 00:00:00
abstract::The cannabinoids, Δ9 tetrahydrocannabinol and its analogue, nabilone, have been found to reliably attenuate the intensity and frequency of post-traumatic nightmares. This essay examines how a traumatic event is captured in the mind, after just a single exposure, and repeatedly replicated during the nights that follow....
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666200114142321
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. METHODS:A homology model of the transmembrane and extracellular regions of an Anophele...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1567201814666161205131213
更新日期:2017-11-14 00:00:00
abstract::It has been well established that there is a connection between type II diabetes (DMTII) and Alzheimer's disease (AD). In fact, the increase in AD incidence may be an emerging complication of DMTII. Both pathologies are related to estradiol (E2) exposure on the one hand, estrogen receptors (ER) are emerging as importa...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X18666201111103024
更新日期:2020-11-10 00:00:00
abstract::Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins: the Aquaporins (AQPs). These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/157015910791233204
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Over 100 people die daily from opioid overdose and $78.5B per year is spent on treatment efforts, however, the real societal cost is multifold greater. Alternative strategies to eradicate/manage drug misuse and addiction need consideration. The perception of opioid addiction as a social/criminal problem has ...
journal_title:Current neuropharmacology
pub_type: 杂志文章
doi:10.2174/1570159X17666191118125702
更新日期:2020-01-01 00:00:00