Abstract:
:Brain and spinal cord injuries present significant therapeutic challenges. The treatments available for these conditions are largely ineffective, partly due to limitations in directly targeting the therapeutic agents to sites of pathology within the central nervous system (CNS). The use of stem cells to treat these conditions presents a novel therapeutic strategy. A variety of stem cell treatments have been examined in animal models of CNS trauma. Many of these studies have used stem cells as a cell-replacement strategy. These investigations have also highlighted the significant limitations of this approach. Another potential strategy for stem cell therapy utilises stem cells as a delivery mechanism for therapeutic molecules. This review surveys the literature relevant to the potential of mesenchymal stem cells for delivery of therapeutic agents in CNS trauma in humans.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Azari MF,Mathias L,Ozturk E,Cram DS,Boyd RL,Petratos Sdoi
10.2174/157015910793358204subject
Has Abstractpub_date
2010-12-01 00:00:00pages
316-23issue
4eissn
1570-159Xissn
1875-6190pii
CN-8-316journal_volume
8pub_type
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