Abstract:
:Liver failure can lead to generalized hyperammonemia, which is thought to be the underlying cause of hepatic encephalopathy. This neuropsychiatric syndrome is accompanied by functional changes of astrocytes. These glial cells enter ammonia-induced self-amplifying cycle characterized by brain oedema, oxidative and osmotic stress that causes modification of proteins and RNA. Consequently, protein expression and function are affected, including that of glutamine synthetase and plasmalemmal glutamate transporters, leading to glutamate excitotoxicity; Ca(2+)-dependent exocytotic glutamate release from astrocytes contributes to this extracellular glutamate overload.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Montana V,Verkhratsky A,Parpura Vdoi
10.2174/1570159X12666140903094700subject
Has Abstractpub_date
2014-07-01 00:00:00pages
324-33issue
4eissn
1570-159Xissn
1875-6190pii
CN-12-324journal_volume
12pub_type
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