Abstract:
:Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lot of evidence that Mst1 plays an important role in cell death which results from tissue injury. Previous studies have shown that Mst1 is not only a target for some apoptosis- related molecules such as caspase 3 and P53, but also act as an activator of these proteinases to magnify apoptosis signal pathways. This article reviews the role of Mst1 in the signaling pathways which is related with the neuronal cell apoptosis or microglia activation following myocardial and brain injury. Therefore, this work contributes to better understanding of the pathological process of myocardial and brain injury.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Li D,Ni H,Rui Q,Gao R,Chen Gdoi
10.2174/1570159X16666180516095949subject
Has Abstractpub_date
2018-01-01 00:00:00pages
1358-1364issue
9eissn
1570-159Xissn
1875-6190pii
CN-EPUB-90449journal_volume
16pub_type
杂志文章,评审abstract::Animal behavioural profiles are commonly employed to investigate new therapeutic agents to treat anxiety disorders as well as to investigate the mechanism of action of anxiolytic drugs. However, many clinically important symptoms of anxiety can not be modelled directly in animals. Human models of anxiety should bridge...
journal_title:Current neuropharmacology
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