Abstract:
:The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focuses on the modulation exerted by central NE pathways on the behavioural and neurotoxic effects produced by the psychostimulant methamphetamine, essentially the modulation of the activity of mesencephalic dopamine (DA) neurons. In fact, although NE in itself mediates some behavioural effects induced by methamphetamine, NE modulation of DA release is pivotal for methamphetamine-induced behavioural states and neurotoxicity. These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters.
journal_name
Curr Neuropharmacoljournal_title
Current neuropharmacologyauthors
Ferrucci M,Giorgi FS,Bartalucci A,Busceti CL,Fornai Fdoi
10.2174/157015913804999522subject
Has Abstractpub_date
2013-01-01 00:00:00pages
80-94issue
1eissn
1570-159Xissn
1875-6190pii
CN-11-80journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Hereditary cerebellar ataxias are a group of disorders characterized by heterogeneous clinical manifestations, progressive clinical course, and diverse genetic causes. No disease modifying treatments are yet available for many of these disorders. Oxidative stress has been recurrently identified in different ...
journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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journal_title:Current neuropharmacology
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pub_type: 杂志文章,评审
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journal_title:Current neuropharmacology
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abstract:BACKGROUND:The only conclusive way to diagnose Alzheimer's is to carry out brain autopsy of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other form of dementia. However, due to the non-feasibility of such methods, to diagnose and conclude the conditions, medical practitioners use ...
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2011-09-01 00:00:00
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journal_title:Current neuropharmacology
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更新日期:2007-12-01 00:00:00
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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journal_title:Current neuropharmacology
pub_type: 杂志文章,评审
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journal_title:Current neuropharmacology
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abstract::The 'omnipresence' of adenosine in all nervous system cells (neurons and glia) together with the intensive release of adenosine following insults, makes adenosine as a sort of 'maestro' of synapses leading to the homeostatic coordination of brain function. Besides direct actions of adenosine on the neurosecretory mech...
journal_title:Current neuropharmacology
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更新日期:2009-09-01 00:00:00
abstract::General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia, and immobility; while they may also induce side effects lik...
journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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journal_title:Current neuropharmacology
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更新日期:2007-01-01 00:00:00
abstract::Tissue plasminogen activator (t-PA) is the only FDA-approved drug for acute ischemic stroke treatment, but its clinical use is limited due to the narrow therapeutic time window and severe adverse effects, including hemorrhagic transformation (HT) and neurotoxicity. One of the potential resolutions is to use adjunct th...
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::Tumor necrosis factor receptor-associated factor (TRAF) is an important binding protein of tumor necrosis factor (TNF) superfamily and the toll/IL-1 receptor (TIR) superfamily, which play an important role in innate immunity and acquired immunity. TRAFs family have 7 members (TRAF1-7), and TRAF6 has its special factur...
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abstract::The heat shock protein (Hsp) family is an evolutionarily conserved system that is charged with preventing unfolded or misfolded proteins in the cell from aggregating. In Alzheimer's disease, extracellular accumulation of the amyloid β peptide (Aβ) and intracellular aggregation of the microtubule associated protein tau...
journal_title:Current neuropharmacology
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更新日期:2011-12-01 00:00:00
abstract::Amphetamines exert their persistent addictive effects by activating brain's reward pathways, perhaps through the release of dopamine in the nucleus accumbens (and/or in other places). On the other hand, there is a relationship between dopamine and all behavioural aspects that involve motor activity and it has been dem...
journal_title:Current neuropharmacology
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abstract::Sleep, an essential physiological process, has been divided into rapid eye movement sleep (REMS) and non-REMS (NREMS) in higher animals. REMS is a unique phenomenon that unlike other sleep-waking states is not under voluntary control. Directly or indirectly it influences or gets influenced by most of the physiological...
journal_title:Current neuropharmacology
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更新日期:2016-01-01 00:00:00
abstract::The transient receptor potential (TRP) proteins are a family of ion channels that act as cellular sensors. Several members of the TRP family are sensitive to oxidative stress mediators. Among them, TRPA1 is remarkably susceptible to various oxidants, and is known to mediate neuropathic pain and respiratory, vascular a...
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