Abstract:
:The release of a GPI-linked oncofetal protein (PLAP) from HEp-2 cells has been studied as an indicator of endogenous PI-specific PLC activation. A non-hydrolysable GTP analogue, EGF and insulin all produced a dose-dependent release of PLAP from these cells. This indicates that an increase in PLC activity following either growth factor binding or G protein activation may cause cellular release of PLAP.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Roberts JM,Kenton P,Johnson PMdoi
10.1016/0014-5793(90)80927-bsubject
Has Abstractpub_date
1990-07-16 00:00:00pages
213-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(90)80927-Bjournal_volume
267pub_type
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