New cytotoxic steroids from the fruits of Syzygium siamense.

Abstract:

:A new sterol, stigmast-5-ene-3beta,17alpha-diol (1), together with six known compounds, stigmast-5-ene-3beta-yl formate (2), stigmast-5-ene-3beta,7alpha-diol (3), stigmast-5-ene-7alpha-methoxy-3beta-ol (4), stigmast-5-ene-3-one (5), 3beta-sitostanol (6), and 3beta-sitosterol (7), was isolated from the fruits of Syzygium siamense, of which compound 2 is reported for the first time from a natural source. Their structures were elucidated by spectroscopic methods. The isolated compounds (1-7) were evaluated for their cytotoxic activities against human oral epidermoid carcinoma cancer (KB), human breast cancer (BC), and human small cell lung cancer (NCI-H187) cell lines.

journal_name

J Asian Nat Prod Res

authors

Chumkaew P,Kato S,Chantrapromma K

doi

10.1080/10286021003762028

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

424-8

issue

5

eissn

1028-6020

issn

1477-2213

pii

922439672

journal_volume

12

pub_type

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