Chemical constituents of the red alga Laurencia tristicha.

Abstract:

:Six new sesquiterpenes, 10-hydroxy-epiaplysin (1), 10-hydroxy-aplysin (2), 10-hydroxy-debromoepiaplysin (3), aplysin-9-ene (4), epiaplysinol (5) and debromoepiaplysinol (6), together with 13 known compounds (7-19), have been isolated from the red alga Laurencia tristicha. The structures of 1-6 were determined by spectroscopic methods including IR, EI-MS, HREI-MS, and 1D and 2D NMR techniques. All compounds were obtained from this species for the first time and were tested for cytotoxic activities against several human cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), hepatoma (Bel 7402), colon cancer (HCT-8) and HeLa cell lines. Compound 6 showed selective cytotoxicity against HeLa cell line with IC(50) 15.5 microM, cholest-5-en-3beta,7alpha-diol (14) was toxic to all tested cell lines with IC(50) values of 16.8, 5.1, 0.5, 0.5, and 0.3 microM, respectively, and other compounds were inactive (IC(50)>10 microg/ml).

journal_name

J Asian Nat Prod Res

authors

Sun J,Shi DY,Li S,Wang SJ,Han LJ,Fan X,Yang YC,Shi JG

doi

10.1080/10286020601103338

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

725-34

issue

6-8

eissn

1028-6020

issn

1477-2213

pii

784382759

journal_volume

9

pub_type

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