Abstract:
:One novel ursolic acid derivative sabiracin 1 (11,25-epoxy-3β-hydroxy-urs-12-en-28-oic acid) was isolated from the leaves of Carissa carandas, together with five known compounds para hydroxy benzaldehyde (2), ursolic acid (3), carissin (4), 22α-hydroxyursolic acid (5) and β-sitosterol-3-O-β-D-glucopyranoside (6). Compounds 2 and 5 were isolated for the first time from this genus. Structure elucidation was done by the help of spectroscopic techniques. Compounds 1-3, 5 and 6 were examined against oral cancer (CAL-27) and lung cancer (NCI-H460) cell lines. 6 showed good activity against oral cancer (IC50 18.69 µM), moderate activity against lung cancer (IC50 63.34 µM) and no cytotoxicity against normal cell lines.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Bano Z,Begum S,Ali SS,Kiran Z,Siddiqui BS,Khawaja S,Ahmed Adoi
10.1080/10286020.2020.1791098subject
Has Abstractpub_date
2020-07-10 00:00:00pages
1-7eissn
1028-6020issn
1477-2213pub_type
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