Four new C10-polyacetylene glycosides from the rhizomes of Atractylodes lancea.

Abstract:

:An ongoing phytochemical investigation of the rhizomes of Atractylodes lancea resulted in the isolation of four new C10-type polyacetylene glycosides (1-4). Their structures were elucidated on the basis of extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of compounds 2-4 were determined by comparing the specific rotations of their aglycones. Notably, compounds 2 and 3 exhibited significant hepatoprotective activities against APAP-induced HepG2 cell injury at a concentration of 10 μM. Compounds 2 and 3 showed weak anti-inflammatory effects on LPS-induced NO production in microglia BV2 cells at a concentration of 10 μM.

journal_name

J Asian Nat Prod Res

authors

Xu K,Feng ZM,Yang YN,Jiang JS,Zhang PC

doi

10.1080/10286020.2016.1247811

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

121-127

issue

2

eissn

1028-6020

issn

1477-2213

journal_volume

19

pub_type

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