Microbial hydroxylation of cinobufagin by Mucor spinosus.

Abstract:

:Mucor spinosus has been employed for the biotransformation of cinobufagin (1) to afford three metabolites. On the basis of their physico-chemical data, the structures of the transformation products have been characterized as 1beta-hydroxy-cinobufagin (2), 12beta-hydroxy-cinobufagin (3) and 1beta,12beta-dihydroxy-cinobufagin (4), of which metabolites 2 and 4 are new compounds. In vitro cytotoxic activities of the biotransformation products and the substrate-cinobufagin have been assayed against four tumor cell lines of Bel 7420, BGC 823, HeLa and HL 60; they all showed cytotoxic activities.

journal_name

J Asian Nat Prod Res

authors

Zhang W,Ye M,Qu GQ,Wu WY,Chen YJ,Guo DA

doi

10.1080/10286020410001690136

keywords:

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

225-9

issue

3

eissn

1028-6020

issn

1477-2213

pii

JQE3T5X6FK50XNPB

journal_volume

7

pub_type

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