Abstract:
:Mucor spinosus has been employed for the biotransformation of cinobufagin (1) to afford three metabolites. On the basis of their physico-chemical data, the structures of the transformation products have been characterized as 1beta-hydroxy-cinobufagin (2), 12beta-hydroxy-cinobufagin (3) and 1beta,12beta-dihydroxy-cinobufagin (4), of which metabolites 2 and 4 are new compounds. In vitro cytotoxic activities of the biotransformation products and the substrate-cinobufagin have been assayed against four tumor cell lines of Bel 7420, BGC 823, HeLa and HL 60; they all showed cytotoxic activities.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Zhang W,Ye M,Qu GQ,Wu WY,Chen YJ,Guo DAdoi
10.1080/10286020410001690136keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
225-9issue
3eissn
1028-6020issn
1477-2213pii
JQE3T5X6FK50XNPBjournal_volume
7pub_type
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