Bioactive amides from Polygonum cuspidatum.

Abstract:

:One pair of new amides enantiomers (1a and 1b) and two known amides were isolated from the rhizomes of Polygonum cuspidatum. Their structures were established using UV, IR, HRESIMS, and NMR data. Notably, compound 1 possesses unique C-C connection between feruloyltyramine and resveratrol. Their absolute configurations were determined by the ECD method. All compounds were evaluated for their α-glucosidase inhibitory activity and compounds 2 and 3 showed significant inhibitory activity with IC50 values of 2.82 and 13.06 μmol/L, respectively (positive control acarbose, IC50 385 μmol/L).

journal_name

J Asian Nat Prod Res

authors

Zhang X,Liu F,Feng ZM,Jiang JS,Yang YN,Zhang PC

doi

10.1080/10286020.2021.1873298

subject

Has Abstract

pub_date

2021-01-18 00:00:00

pages

1-7

eissn

1028-6020

issn

1477-2213

pub_type

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