Abstract:
:One pair of new amides enantiomers (1a and 1b) and two known amides were isolated from the rhizomes of Polygonum cuspidatum. Their structures were established using UV, IR, HRESIMS, and NMR data. Notably, compound 1 possesses unique C-C connection between feruloyltyramine and resveratrol. Their absolute configurations were determined by the ECD method. All compounds were evaluated for their α-glucosidase inhibitory activity and compounds 2 and 3 showed significant inhibitory activity with IC50 values of 2.82 and 13.06 μmol/L, respectively (positive control acarbose, IC50 385 μmol/L).
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Zhang X,Liu F,Feng ZM,Jiang JS,Yang YN,Zhang PCdoi
10.1080/10286020.2021.1873298subject
Has Abstractpub_date
2021-01-18 00:00:00pages
1-7eissn
1028-6020issn
1477-2213pub_type
杂志文章abstract::A profiling analysis of the total isoflavone extract of the root of Pueraria lobata (Wild.) Ohwi was performed using HPLC coupled with ESI-ion trap mass spectrometry. A total of seven isoflavones were identified according to their retention times, UV, MS data, and comparing with the literature data. Among them, two pr...
journal_title:Journal of Asian natural products research
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