Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression.

Abstract:

:Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro. Based on these findings, corydaline could be a potential lead or supplement for the development of new anti-EV71 agents in the future.

journal_name

J Asian Nat Prod Res

authors

Wang HQ,Hu J,Yan HY,Wu S,Li YH

doi

10.1080/10286020.2017.1386658

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1124-1133

issue

11

eissn

1028-6020

issn

1477-2213

journal_volume

19

pub_type

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