Abstract:
:Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro. Based on these findings, corydaline could be a potential lead or supplement for the development of new anti-EV71 agents in the future.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Wang HQ,Hu J,Yan HY,Wu S,Li YHdoi
10.1080/10286020.2017.1386658subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1124-1133issue
11eissn
1028-6020issn
1477-2213journal_volume
19pub_type
杂志文章abstract::Five labdane-type diterpenes, vitexilactone (1), (rel 5S,6R,8R,9R,10S)-6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (2), rotundifuran (3), vitetrifolin D (4), and vitetrifolin E (5), have been isolated from Vitex trifolia L., a Chinese folk medicine used to treat cancers, as new cell cycle inhibitors and apoptosis in...
journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
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journal_title:Journal of Asian natural products research
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of Asian natural products research
pub_type: 杂志文章
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journal_title:Journal of Asian natural products research
pub_type: 杂志文章
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abstract::Three new eremophilane-type sesquiterpenoids, alashanoids K-M (1-3), and one known analogue (4) were isolated from the peeled stems of Syringa pinnatifolia. All the compounds were isolated from the genus Syringa for the first time. Structures of these compounds were established using 1D and 2D NMR and MS data. The abs...
journal_title:Journal of Asian natural products research
pub_type: 杂志文章
doi:10.1080/10286020.2019.1694516
更新日期:2019-12-01 00:00:00