Abstract:
:Bioassay-guided fractionation of the ethanolic extract of Senecio scandens led to the isolation of four new compounds 4, 5, 7, and 8, along with four known jacaranone analogs (1, 2, 3, 6). Their structures were elucidated on the basis of spectral and chemical evidence. Compound 7 was obtained as a tautomeric mixture of alpha/beta-epimer. The cytotoxic activities of these compounds were evaluated. Among these, compounds 5 and 8 showed potent cytotoxicities. The benzoquinone derivative, jacaranone ethyl ester (1), was the major cytotoxic constituent in this plant with IC(50)s at a range of 0.5-1.0 microg/ml against various tumor cell lines. The SAR of these jacaranone analogs (1-8), isolated from S. scandens, was also discussed.
journal_name
J Asian Nat Prod Resjournal_title
Journal of Asian natural products researchauthors
Tian XY,Wang YH,Yang QY,Yu SS,Fang WSdoi
10.1080/10286020802413239subject
Has Abstractpub_date
2009-01-01 00:00:00pages
63-8issue
1eissn
1028-6020issn
1477-2213pii
908233549journal_volume
11pub_type
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