Jacaranone analogs from Senecio scandens.

Abstract:

:Bioassay-guided fractionation of the ethanolic extract of Senecio scandens led to the isolation of four new compounds 4, 5, 7, and 8, along with four known jacaranone analogs (1, 2, 3, 6). Their structures were elucidated on the basis of spectral and chemical evidence. Compound 7 was obtained as a tautomeric mixture of alpha/beta-epimer. The cytotoxic activities of these compounds were evaluated. Among these, compounds 5 and 8 showed potent cytotoxicities. The benzoquinone derivative, jacaranone ethyl ester (1), was the major cytotoxic constituent in this plant with IC(50)s at a range of 0.5-1.0 microg/ml against various tumor cell lines. The SAR of these jacaranone analogs (1-8), isolated from S. scandens, was also discussed.

journal_name

J Asian Nat Prod Res

authors

Tian XY,Wang YH,Yang QY,Yu SS,Fang WS

doi

10.1080/10286020802413239

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

63-8

issue

1

eissn

1028-6020

issn

1477-2213

pii

908233549

journal_volume

11

pub_type

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